Development and Validation of an OMERACT MRI Whole-Body Score for Inflammation in Peripheral Joints and Entheses in Inflammatory Arthritis (MRI-WIPE).

Krabbe, Simon Eshed, Iris Gandjbakhch, Frédérique Pedersen, Susanne J Bird, Paul Mathew, Ashish J Lambert, Robert G Maksymowych, Walter P Glinatsi, Daniel Stoenoiu, Maria [UCL] Poggenborg, René Jans, Lennart Jaremko, Jacob L Herregods, Nele Foltz, Violaine Conaghan, Philip G Althoff, Christian E Paschke, Joel Peterfy, Charles Hermann, Kay-Geert A Østergaard, Mikkel OMERACT MRI in Arthritis Working Group et al.[show all]

OBJECTIVE: To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis. METHODS: After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0-3 separately for synovitis and osteitis, and 33 entheses 0-3 separately for soft tissue inflammation and osteitis. RESULTS: In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κ ranged 0.35-0.77. CONCLUSION: Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.