User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Cerebrospinal fluid TAU protein and amyloid beta42 in mild cognitive impairment: prediction of progression to Alzheimer's disease and correlation with the neuropsychological examination.

Primary tabs

Ivanoiu, Adrian [UCL] Sindic, Christian [UCL]

Cerebrospinal fluid (CSF) TAU protein and Amyloid beta42 were able to distinguish between 28 mild cognitive impairment (MCI) patients and both 38 normal aged and 17 anxious and depressed elderly patients, with good sensitivity/specificity when the two measures were combined. These biological markers are independent predictors of the presence of Alzheimer disease (AD), in addition to memory performance. Low Amyloid beta42 level was predictor of a fast progression of MCI patients to full blown dementia. The TAU protein level tended to correlate with memory performance, presumably in relation with the extent of the bilateral medio-temporal damage in early AD.

Document type Article de périodique (Journal article) – Article de recherche – Comparative Study, Journal Article
Access type Accès restreint
Publication date 2005
Language Anglais
Journal information "Neurocase" - Vol. 11, no. 1, p. 32-39 (2005)
Peer reviewed yes
Publisher Psychology Press ((United Kingdom) Hove)
issn 1355-4794
e-issn 1465-3656
Publication status Publié
Affiliations UCL - MD/NOPS - Département de neurologie et de psychiatrie
UCL - (SLuc) Service de neurologie
MESH Subject Aged ; Alzheimer Disease - cerebrospinal fluid - diagnosis - physiopathology ; Amyloid beta-Protein - cerebrospinal fluid ; Analysis of Variance ; Cognition Disorders - cerebrospinal fluid - diagnosis - physiopathology ; Dementia ; Disease Progression ; Evaluation Studies as Topic ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Peptide Fragments - cerebrospinal fluid ; Predictive Value of Tests ; Psychiatric Status Rating Scales ; Sensitivity and Specificity ; tau Proteins - cerebrospinal fluid
Links
Bibliographic reference Ivanoiu, Adrian ; Sindic, Christian. Cerebrospinal fluid TAU protein and amyloid beta42 in mild cognitive impairment: prediction of progression to Alzheimer's disease and correlation with the neuropsychological examination.. In: Neurocase, Vol. 11, no. 1, p. 32-39 (2005)
Permanent URL http://hdl.handle.net/2078.1/23950