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Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991-2000).

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Wilkinson, J D Shaw, S Andersen, K E Brandao, F M Bruynzeel, D P Lachapelle, Jean-Marie [UCL] Wahlberg, J E

A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2002
Language Anglais
Journal information "Contact dermatitis" - Vol. 46, no.4, p. 207-210 (2002)
Peer reviewed yes
issn 0105-1873
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de dermatologie
MESH Subject Allergens ; Dermatitis, Allergic Contact ; Europe ; Formaldehyde ; Humans ; Nitriles ; Patch Tests ; Preservatives, Pharmaceutical ; Thiazoles
Keywords 5-chloro-2-methyl-4-isothiazolin-3-one+2-methyl-4-isothiazolin-3-one ; Diazolidinyl urea ; Formaldehyde ; Imidazolidinyl urea ; Methyldibromoglutaronitrile ; Parabens ; Patch test sensitization ; Preservatives ; Quaternium-15
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Bibliographic reference Wilkinson, J D ; Shaw, S ; Andersen, K E ; Brandao, F M ; Bruynzeel, D P ; et. al. Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991-2000).. In: Contact dermatitis, Vol. 46, no.4, p. 207-210 (2002)
Permanent URL http://hdl.handle.net/2078.1/232571