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A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

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Stephens, Philip Edkins, Sarah Davies, Helen Greenman, Chris Cox, Charles Brasseur, Francis [UCL] Wooster, Richard

We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2005
Language Anglais
Journal information "Nature Genetics" - Vol. 37, no. 6, p. 590-2 (2005)
Publisher Nature Publishing Group (New York)
issn 1061-4036
e-issn 1546-1718
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Unité d'oncologie médicale
MESH Subject Aged ; Breast Neoplasms ; Carcinoma, Ductal, Breast ; DNA Mutational Analysis ; Female ; Humans ; Multigene Family ; Mutation ; Protein Kinases
Links
Bibliographic reference Stephens, Philip ; Edkins, Sarah ; Davies, Helen ; Greenman, Chris ; Cox, Charles ; et. al. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.. In: Nature Genetics, Vol. 37, no. 6, p. 590-2 (2005)
Permanent URL http://hdl.handle.net/2078.1/232061