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Role of the sarco-endoplasmic reticulum Ca2+-ATPase SERCA3 in Ca2+ signaling in mouse Beta-cells

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Arredouani, Abdelilah [UCL] Pertusa, José [UCL] Rolland, Jean-François [UCL] Liu, Lynne H Shull, Gary E Henquin, Jean-Claude [UCL] Gilon, Patrick [UCL]

Pancreatic islets express both the high Ca" -affinity SERCA2b and the low Ca"-affinity SERCA3. Dysregulation of the SERCA3 activity has been associated with type 2 diabetes in mice and humans. Wild type (+f+) and SERCA3 KO (-f.) mice were used to evaluate the role of SERCA3 in J3-cell [Ca'+], regulation and insulin secretion, and to estimate its contribution to glucose homeostasis [...]

Document type Communication à un colloque (Conference Paper) – Présentation orale avec comité de sélection, Abstract
Access type Accès libre
Publication date 2001
Language Anglais
Conference "37th Annual Meeting of the EASD", (United Kingdom) Glasgow (du 09/09/2001 au 13/09/2001)
Journal information "Diabetologia" - Vol. 44, no.Suppl 1, p. A125 (2001)
Peer reviewed yes
issn 0012-186X
e-issn 1432-0428
Publisher Springer ((Germany) Heidelberg )
Publication status Publié
Affiliation UCL - MD/FSIO - Département de physiologie et pharmacologie
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Bibliographic reference Arredouani, Abdelilah ; Pertusa, José ; Rolland, Jean-François ; Liu, Lynne H ; Shull, Gary E ; et. al. Role of the sarco-endoplasmic reticulum Ca2+-ATPase SERCA3 in Ca2+ signaling in mouse Beta-cells.37th Annual Meeting of the EASD ((United Kingdom) Glasgow, du 09/09/2001 au 13/09/2001). In: Diabetologia, Vol. 44, no.Suppl 1, p. A125 (2001)
Permanent URL http://hdl.handle.net/2078.1/230701