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A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.

Bibliographic reference Sato, Takeshi ; Tang, Tzu-Chun ; Reubins, Gabriella ; Fei, Jeffrey Z ; Fujimoto, Taiki ; et. al. A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, no. 5, p. 1421-6 (2009)
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  1. Woolf Clifford J., Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management, 10.7326/0003-4819-140-8-200404200-00010
  2. Cao X., A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60, 10.1126/science.1058783
  3. Burdick, Journal of Biological Chemistry, 267, 546 (1992)
  4. Weidemann Andreas, Eggert Simone, Reinhard Friedrich B. M., Vogel Markus, Paliga Krzysztof, Baier Gottfried, Masters Colin L., Beyreuther Konrad, Evin Geneviève, A Novel ɛ-Cleavage within the Transmembrane Domain of the Alzheimer Amyloid Precursor Protein Demonstrates Homology with Notch Processing†, 10.1021/bi015794o
  5. Ye J., Dave U. P., Grishin N. V., Goldstein J. L., Brown M. S., Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by Site-2 protease, 10.1073/pnas.97.10.5123
  6. Li Shun-Cheng, Deber Charles M., Glycine and β-branched residues support and modulate peptide helicity in membrane environments, 10.1016/0014-5793(92)81106-v
  7. Deber C. M., Khan A. R., Li Z., Joensson C., Glibowicka M., Wang J., Val-->Ala mutations selectively alter helix-helix packing in the transmembrane segment of phage M13 coat protein., 10.1073/pnas.90.24.11648
  8. Russ William P, Engelman Donald M, The GxxxG motif: A framework for transmembrane helix-helix association, 10.1006/jmbi.1999.3489
  9. Munter Lisa-Marie, Voigt Philipp, Harmeier Anja, Kaden Daniela, Gottschalk Kay E, Weise Christoph, Pipkorn Rüdiger, Schaefer Michael, Langosch Dieter, Multhaup Gerd, GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42, 10.1038/sj.emboj.7601616
  10. Kienlen-Campard Pascal, Tasiaux Bernadette, Van Hees Joanne, Li Mingli, Huysseune Sandra, Sato Takeshi, Fei Jeffrey Z., Aimoto Saburo, Courtoy Pierre J., Smith Steven O., Constantinescu Stefan N., Octave Jean-Noël, Amyloidogenic Processing but Not Amyloid Precursor Protein (APP) Intracellular C-terminal Domain Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs, 10.1074/jbc.m707142200
  11. Gorman Paul M, Kim Sanguk, Guo Meng, Melnyk Roman A, McLaurin Joanne, Fraser Paul E, Bowie James U, Chakrabartty Avijit, Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants, 10.1186/1471-2202-9-17
  12. Smith Steven O., Eilers Markus, Song David, Crocker Evan, Ying Weiwen, Groesbeek Michel, Metz Guenter, Ziliox Martine, Aimoto Saburo, Implications of Threonine Hydrogen Bonding in the Glycophorin A Transmembrane Helix Dimer, 10.1016/s0006-3495(02)75590-2
  13. Saitô Hazime, Tuzi Satoru, Naito Akira, Empirical Versus N On Empirical Evaluation Of Secondary Structure Of Fibrous And Membrane Proteins By Solid-State Nmr: A Practical Approach, Annual Reports on NMR Spectroscopy (1998) ISBN:9780125053365 p.79-121, 10.1016/s0066-4103(08)60006-x
  14. Scheuermann Stefan, Hambsch Boris, Hesse Lars, Stumm Joachim, Schmidt Carsten, Beher Dirk, Bayer Thomas A., Beyreuther Konrad, Multhaup Gerd, Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease, 10.1074/jbc.m105410200
  15. Vooijs Marc, Schroeter Eric H., Pan Yonghua, Blandford Mary, Kopan Raphael, Ectodomain Shedding and Intramembrane Cleavage of Mammalian Notch Proteins Are Not Regulated through Oligomerization, 10.1074/jbc.m409430200
  16. Senes A., Ubarretxena-Belandia I., Engelman D. M., The C --H***O hydrogen bond: A determinant of stability and specificity in transmembrane helix interactions, 10.1073/pnas.161280798
  17. Ramelot Theresa A., Gentile Lisa N., Nicholson Linda K., Transient Structure of the Amyloid Precursor Protein Cytoplasmic Tail Indicates Preordering of Structure for Binding to Cytosolic Factors†, 10.1021/bi992580m
  18. Ramelot Theresa A., Nicholson Linda K., Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR11Edited by P. E. Wright, 10.1006/jmbi.2001.4535
  19. Dovey H. F., John V., Anderson J. P., Chen L. Z., De Saint Andrieu P., Fang L. Y., Freedman S. B., Folmer B., Goldbach E., Holsztynska E. J., Hu K. L., Johnson-Wood K. L., Kennedy S. L., Kholodenko D., Knops J. E., Latimer L. H., Lee M., Liao Z., Lieberburg I. M., Motter R. N., Mutter L. C., Nietz J., Quinn K. P., Sacchi K. L., Seubert P. A., Shopp G. M., Thorsett E. D., Tung J. S., Wu J., Yang S., Yin C. T., Schenk D. B., May P. C., Altstiel L. D., Bender M. H., Boggs L. N., Britton T. C., Clemens J. C., Czilli D. L., Dieckman-McGinty D. K., Droste J. J., Fuson K. S., Gitter B. D., Hyslop P. A., Johnstone E. M., Li W-Y., Little S. P., Mabry T. E., Miller F. D., Ni B., Nissen J. S., Porter W. J., Potts B. D., Reel J. K., Stephenson D., Su Y., Shipley L. A., Whitesitt C. A., Yin T., Audia J. E., Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain : γ-secretase inhibitors reduce Aβ levels in PDAPP mouse brain, 10.1046/j.1471-4159.2001.00012.x
  20. De Strooper Bart, Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease, 10.1038/sj.embor.7400897
  21. Yu Chunjiang, Kim Seong-Hun, Ikeuchi Takeshi, Xu Huaxi, Gasparini Laura, Wang Rong, Sisodia Sangram S., Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ : EVIDENCE FOR DISTINCT MECHANISMS INVOLVED IN γ-SECRETASE PROCESSING OF THE APP AND Notch1 TRANSMEMBRANE DOMAINS, 10.1074/jbc.c100410200
  22. Qi-Takahara Y., Longer Forms of Amyloid   Protein: Implications for the Mechanism of Intramembrane Cleavage by  -Secretase, 10.1523/jneurosci.1575-04.2005
  23. Kakuda Nobuto, Funamoto Satoru, Yagishita Sousuke, Takami Mako, Osawa Satoko, Dohmae Naoshi, Ihara Yasuo, Equimolar Production of Amyloid β-Protein and Amyloid Precursor Protein Intracellular Domain from β-Carboxyl-terminal Fragment by γ-Secretase, 10.1074/jbc.m513453200
  24. Chandu Dilip, Huppert Stacey S., Kopan Raphael, Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase, 10.1111/j.1471-4159.2005.03547.x
  25. Wiley Jesse C., Hudson Mark, Kanning Kevin C., Schecterson Leslyanne C., Bothwell Mark, Familial Alzheimer's disease mutations inhibit γ-secretase-mediated liberation of β-amyloid precursor protein carboxy-terminal fragment, 10.1111/j.1471-4159.2005.03266.x
  26. Hecimovic Silva, Wang Jun, Dolios Georgia, Martinez Maribel, Wang Rong, Goate Alison M., Mutations in APP have independent effects on Aβ and CTFγ generation, 10.1016/j.nbd.2004.04.018
  27. Wang Yongcheng, Zhang Yingjiu, Ha Ya, Crystal structure of a rhomboid family intramembrane protease, 10.1038/nature05255
  28. Feng L., Yan H., Wu Z., Yan N., Wang Z., Jeffrey P. D., Shi Y., Structure of a Site-2 Protease Family Intramembrane Metalloprotease, 10.1126/science.1150755
  29. Duncan Elizabeth A., Davé Utpal P., Sakai Juro, Goldstein Joseph L., Brown Michael S., Second-site Cleavage in Sterol Regulatory Element-binding Protein Occurs at Transmembrane Junction as Determined by Cysteine Panning, 10.1074/jbc.273.28.17801
  30. Takegoshi K., Nakamura Shinji, Terao Takehiko, 13C–1H dipolar-assisted rotational resonance in magic-angle spinning NMR, 10.1016/s0009-2614(01)00791-6
  31. Huysseune Sandra, Kienlen-Campard Pascal, Octave Jean-Noël, Fe65 does not stabilize AICD during activation of transcription in a luciferase assay, 10.1016/j.bbrc.2007.06.186
  32. Sergeant Nicolas, David Jean-Philippe, Champain Danie, Ghestem Antoine, Wattez Annick, Delacourte André, Progressive decrease of amyloid precursor protein carboxy terminal fragments (APP-CTFs), associated with tau pathology stages, in Alzheimer's disease : Loss of APP-CTFs linked to tau pathology in AD, 10.1046/j.1471-4159.2002.00901.x