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Increased CD8CD28 circulating T cells and high blood interferon score characterize the systemic inflammation of amyopathic dermatomyositis.

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Cassius, Charles [UCL] Branchtein, Mylene Battistella, Maxime Amode, Reyhan Lepelletier, Clémence Bouaziz, Jean-David

(eng) Amyopathic dermatomyositis (ADM) is a subtype of DM defined by the presence of cutaneous signs of DM with no evidence of muscle weakness or abnormal muscle enzymes for ≥ 6 months.1 Classical DM (CDM) is characterized by modification of circulating lymphocytes 4, type I interferon (IFN) signature 2, elevation of serum pro-inflammatory cytokines 3. Pathophysiology of ADM is less studied. We analysed circulating T cells by flowcytometry (using specific monoclonal antibodies), peripheral blood mononuclear cells type I IFN signature by PCR and serum cytokine levels by ELISA in a series of 17 ADM and 15 CDM patients. [...]

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2019
Language Anglais
Journal information "Journal of the American Academy of Dermatology" - Vol. 85, no. 3, p. 755-758 (2019)
Peer reviewed yes
Publisher Mosby ((United States) St. Louis, MO)
issn 0190-9622
e-issn 1097-6787
Publication status Publié
Affiliations UCL - SSS/IREC/MONT - Pôle Mont Godinne
UCL - (MGD) Dermatologie
Keywords CD28- lymphocytes ; adaptive immune system ; amyopathic dermatomyositis ; dermatomyositis ; flowcytometry ; type I interferon
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Bibliographic reference Cassius, Charles ; Branchtein, Mylene ; Battistella, Maxime ; Amode, Reyhan ; Lepelletier, Clémence ; et. al. Increased CD8CD28 circulating T cells and high blood interferon score characterize the systemic inflammation of amyopathic dermatomyositis.. In: Journal of the American Academy of Dermatology, Vol. 85, no. 3, p. 755-758 (2019)
Permanent URL http://hdl.handle.net/2078.1/225878