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Severe hepatitis associated with the use of black cohosh: a report of two cases and an advice for caution.

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Piérard, Sophie F. [UCL] Coche, Jean-Charles Lanthier, Philippe Dekoninck, Xavier Lanthier, Nicolas [UCL] Rahier, Jacques [UCL] Geubel, André [UCL]

In spite of the fact that severe side effects have been reported, black cohosh [Actaea racemosa (syn. Cimifuga racemosa)] is likely to be one of the most popular herbs used in the treatment of postmenopausal symptoms and menstrual dysfunction. We report the cases of two patients, one with submassive liver necrosis and the other with chronic hepatitis most likely related to the use of two different preparations containing black cohosh. This represents another advice for caution concerning this popular preparation of inconsistent therapeutic value.

Document type Article de périodique (Journal article) – Journal Article
Publication date 2009
Journal information "European journal of gastroenterology & hepatology" - Vol. 21, no. 8, p. 941-5 (2009)
Peer reviewed yes
e-issn 1473-5687
issn 0954-691X
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de pathologies cardiovasculaires intensives
UCL - (SLuc) Service d'anatomie pathologique
UCL - (SLuc) Service d'hépato-gastro-entérologie
MESH Subject Phytotherapy - adverse effects ; Nonprescription Drugs - adverse effects ; Middle Aged ; Humans ; Female ; Drug-Induced Liver Injury, Chronic - pathology ; Cimicifuga - adverse effects
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Bibliographic reference Piérard, Sophie F. ; Coche, Jean-Charles ; Lanthier, Philippe ; Dekoninck, Xavier ; Lanthier, Nicolas ; et. al. Severe hepatitis associated with the use of black cohosh: a report of two cases and an advice for caution.. In: European journal of gastroenterology & hepatology, Vol. 21, no. 8, p. 941-5 (2009)
Permanent URL http://hdl.handle.net/2078.1/22323