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F-18 FDG PET/CT as a noninvasive diagnostic and follow-up tool in brown tumors due to secondary hyperparathyroidism

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Hermoye, Aurélie [UCL] Malghem, Jacques [UCL] Lecouvet, Frédéric [UCL] Goffin, Eric [UCL] Lonneux, Max [UCL] Lhommel, Renaud [UCL]

We report the case of a 47-year-old woman, who had hemodialysis with secondary hyperparathyroidism and who developed progressive unbearable leg pain. Bone lesions suggestive of brown tumors were observed on initial x-ray examinations. This etiology was strengthened by PET/CT images showing F-18 FDG avid osteolytic lesions but no abnormal uptake suggestive of a primary neoplasm. The major metabolic regression of the lesions 6 months after total parathyroidectomy eventually confirmed the diagnosis. This case illustrates the potential usefulness of PET/CT in the noninvasive diagnosis and follow-up of brown tumors.

Document type Article de périodique (Journal article) – Article de recherche – Case Reports, Journal Article
Access type Accès restreint
Publication date 2009
Language Anglais
Journal information "Clinical Nuclear Medicine" - Vol. 34, no. 5, p. 330-332 (2009)
Peer reviewed yes
Publisher Lippincott Williams & Wilkins ((United States) Philadelphia)
issn 0363-9762
e-issn 1536-0229
Publication status Publié
Affiliations UCL - MD/RAIM - Département de radiologie et d'imagerie médicale
UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de néphrologie
UCL - (SLuc) Service de médecine nucléaire
MESH Subject Tomography, X-Ray Computed ; Technetium Tc 99m Sestamibi - diagnostic use ; Radiopharmaceuticals - diagnostic use ; Positron-Emission Tomography ; Middle Aged ; Hyperparathyroidism, Secondary - complications - radiography - radionuclide imaging ; Humans ; Giant Cell Tumor of Bone - etiology - radiography - radionuclide imaging ; Follow-Up Studies ; Fluorodeoxyglucose F18 - diagnostic use ; Female ; Bone Neoplasms - etiology - radiography - radionuclide imaging
Keywords Brown tumors ; Secondary hyperparathyroidism ; Parathyroid scintigraphy ; F-18 FDG PET/CT
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Bibliographic reference Hermoye, Aurélie ; Malghem, Jacques ; Lecouvet, Frédéric ; Goffin, Eric ; Lonneux, Max ; et. al. F-18 FDG PET/CT as a noninvasive diagnostic and follow-up tool in brown tumors due to secondary hyperparathyroidism. In: Clinical Nuclear Medicine, Vol. 34, no. 5, p. 330-332 (2009)
Permanent URL http://hdl.handle.net/2078.1/22291