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Early Versus Late Oral Refeeding After Pancreaticoduodenectomy for Malignancy: a Comparative Belgian-French Study in Two Tertiary Centers.

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Navez, Julie [UCL] Hubert, Catherine [UCL] Dokmak, Safi Frick de la Maza, Isadora [UCL] Tabchouri, Nicolas Zech, Francis [UCL] Gigot, Jean-François [UCL] Sauvanet, Alain

(eng) BACKGROUND: In the era of fast-track surgery, because pancreaticoduodenectomy (PD) carries a significant morbidity, surgeons hesitate to begin early oral feeding and achieve early discharge. We compared the outcome of two different approaches to the postoperative management of PD in two tertiary centers. METHODS: Of patients having undergone PD for malignancy from 2008 to 2017, 100 patients who received early postoperative oral feeding (group A) were compared to 100 patients from another center who received early enteral feeding and a delayed oral diet (group B). Surgical indication and approach and type of pancreatic anastomosis were similar between both groups. Postoperative outcomes were retrospectively reviewed. RESULTS: Patient characteristics were similar between both groups, except significantly more neoadjuvant treatment in group A (A = 20% vs. B = 9%, p < 0.01). Mortality rates were 3% and 4% in groups A and B, respectively (p = 0.71). The rate of severe postoperative morbidity was significantly lower in group A (13% vs. 26%, p = 0.02), resulting in a lower reoperation rate (p < 0.01). Delayed gastric emptying and clinically relevant pancreatic fistula were similar between both groups but chyle leaks were more frequent in group A (10% vs. 3%, p = 0.04). The median hospital stay was shorter in group A (16 vs. 20 days, p < 0.01). CONCLUSION: In the present study, early postoperative oral feeding after PD was associated with a shorter hospital stay and did not increase severe postoperative morbidity or the rate of pancreatic fistula. However, it resulted in more chyle leaks and did not prevent delayed gastric emptying.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2020
Language Anglais
Journal information "Journal of Gastrointestinal Surgery" - Vol. 24, no. 7, p. 1597-1604 (2020)
Peer reviewed yes
Publisher Springer ((United States) New York, NY)
issn 1091-255X
e-issn 1873-4626
Publication status Publié
Affiliations UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale
UCL - (SLuc) Service de chirurgie et transplantation abdominale
Keywords Chyle leaks ; Delayed gastric emptying ; Early oral feeding ; Pancreatic fistula ; Pancreaticoduodenectomy
Links
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Bibliographic reference Navez, Julie ; Hubert, Catherine ; Dokmak, Safi ; Frick de la Maza, Isadora ; Tabchouri, Nicolas ; et. al. Early Versus Late Oral Refeeding After Pancreaticoduodenectomy for Malignancy: a Comparative Belgian-French Study in Two Tertiary Centers.. In: Journal of Gastrointestinal Surgery, Vol. 24, no. 7, p. 1597-1604 (2020)
Permanent URL http://hdl.handle.net/2078.1/218196