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Robot-assisted line bisection in patients with Complex Regional Pain Syndrome

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Verfaille, Charlotte [UCL] Filbrich, Lieve [UCL] Cordova Bulens, David [UCL] Lefèvre, Philippe [UCL] Berquin, Anne [UCL] Barbier, Olivier [UCL] Libouton, Xavier [UCL] Fraselle, Virginie [UCL] Legrain, Valéry [UCL]

(eng) Complex Regional Pain Syndrome (CRPS) is characterized by pain, motor and inflammatory symptoms usually affecting one limb. Cognitive difficulties have been reported to affect patients’ ability to represent, perceive and use their affected limb. It is debated whether these difficulties result from deficits in controlling goal-directed movements in space or from a learned strategy to protect the affected limb. In order to dissociate the two hypotheses, patients with upper-limb CRPS were asked to move with their unaffected hand towards visual targets projected at different positions on a horizontal semi-reflexive mirror. By means of a robotic handle placed below the screen, they were asked to move a cursor, to reach and cross lines at their estimated midpoint. In some of the stimulation series, the affected hand was placed below the mirror so that some lines appeared projected onto that hand. Vision of the hands and the robotic handle was preserved or prevented by opening or closing a shutter below the mirror. Lines were displayed on the mirror according to which part of the body was affected (ispi- vs. contralateral) and the actual position of the affected hand (inside vs. outside the workspace). Comparatively to control participants, CRPS patients generally biased their estimation by bisecting the lines towards their left side, irrelative of which part of the body was affected and the position of the affected hand, both in ipsi- and contralateral space, with only a few exceptions. Our results are in line with previous studies having described a visuospatial deficit in CRPS patients and discard the explanation of observed symptoms in terms of learned nonuse strategies, as only the unaffected hand was used to perform the task. It is suggested that CRPS patients can display difficulties to perform tasks requesting visuo-motor coordination, reflecting the complex cortical reorganization occurring in CRPS.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2019
Language Anglais
Journal information "PLoS One" - Vol. 14, no. 5, p. e0213732 [1-30] (2019)
Peer reviewed yes
Publisher Public Library of Science ((United States) San Francisco, CA)
e-issn 1932-6203
Publication status Publié
Affiliations UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
UCL - SSH/IPSY - Psychological Sciences Research Institute
UCL - SST/ICTM/INMA - Pôle en ingénierie mathématique
UCL - SSS/IREC/NMSK - Neuro-musculo-skeletal Lab
UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur
UCL - (SLuc) Service de médecine physique et de réadaptation motrice
Keywords General Biochemistry ; Genetics and Molecular Biology ; General Agricultural and Biological Sciences ; General Medicine
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Bibliographic reference Verfaille, Charlotte ; Filbrich, Lieve ; Cordova Bulens, David ; Lefèvre, Philippe ; Berquin, Anne ; et. al. Robot-assisted line bisection in patients with Complex Regional Pain Syndrome. In: PLoS One, Vol. 14, no. 5, p. e0213732 [1-30] (2019)
Permanent URL http://hdl.handle.net/2078.1/216578