Lemaigre, Frédéric
[UCL]
Courtois, S J
Durviaux, S M
Egan, C J
LaFontaine, D A
Rousseau, Guy
[UCL]
The expression of the human growth hormone (hGH) gene is regulated by several transcription factors. Basal level transcription factors include TATA box-binding proteins, Sp1, USF and CTF/NF-1. The hGH gene is expressed only in pituitary somatotrophs, and the pituitary-specific GHF-1/Pit-1 protein is a potent transcriptional stimulator. Glucocorticoid and thyroid hormones, insulin, and GHRH which acts via cAMP, also control hGH gene transcription via trans-acting factors some of which are the hormone receptors themselves. Three transcription initiation sites were detected when hGH gene promoter activity was studied in a cell-free system. This system enabled us to delineate the respective role of some transcription factors and to propose a model that accounts for the basal, pituitary-specific, and hormonal control of hGH gene expression.
Bibliographic reference |
Lemaigre, Frédéric ; Courtois, S J ; Durviaux, S M ; Egan, C J ; LaFontaine, D A ; et. al. Analysis of cis- and trans-acting elements in the hormone-sensitive human somatotropin gene promoter. In: Journal of Steroid Biochemistry, Vol. 34, no. 1-6, p. 79-83 (1989) |
Permanent URL |
http://hdl.handle.net/2078.1/21612 |