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OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6

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Jacquemin, Patrick [UCL] Lannoy, Vincent [UCL] Rousseau, Guy [UCL] Lemaigre, Frédéric [UCL]

Transcription factors of the ONECUT class, whose prototype is hepatocyte nuclear factor (HNF)-6, are characterized by the presence of a single cut domain and by a peculiar homeodomain (Lannoy, V. J., Bürglin, T. R., Rousseau, G. G., and Lemaigre, F. P. (1998) J. Biol. Chem. 273, 13552-13562). We report here the identification and characterization of human OC-2, the second mammalian member of this class. The OC-2 gene is located on human chromosome 18. The distribution of OC-2 mRNA in humans is tissue-restricted, the strongest expression being detected in the liver and skin. The amino acid sequence of OC-2 contains several regions of high similarity to HNF-6. The recognition properties of OC-2 for binding sites present in regulatory regions of liver-expressed genes differ from, but overlap with, those of HNF-6. Like HNF-6, OC-2 stimulates transcription of the hnf-3beta gene in transient transfection experiments, suggesting that OC-2 participates in the network of transcription factors required for liver differentiation and metabolism.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1999
Journal information "Journal of Biological Chemistry" - Vol. 274, no. 5, p. 2665-2671 (1999)
Peer reviewed yes
Publisher American Society for Biochemistry and Molecular Biology, Inc.
issn 0021-9258
e-issn 1083-351X
Publication status Publié
Affiliation UCL - MD/BICL - Département de biochimie et de biologie cellulaire
MESH Subject Amino Acid Sequence ; Animals ; Base Sequence ; COS Cells ; Chromosomes, Human, Pair 18 ; DNA - metabolism ; DNA-Binding Proteins - biosynthesis - genetics ; Hepatocyte Nuclear Factor 3-beta ; Hepatocyte Nuclear Factor 6 ; Homeodomain Proteins - chemistry - genetics - physiology ; Humans ; Liver - chemistry - physiology ; Molecular Sequence Data ; Nuclear Proteins - biosynthesis - genetics ; RNA, Messenger - metabolism ; Rats ; Skin - chemistry ; Trans-Activators - chemistry - genetics - physiology ; Transcription Factors - chemistry - genetics - physiology ; Transcription, Genetic ; Tumor Cells, Cultured
Links
  1. Kornberg, J. Biol. Chem., 268, 26813 (1993)
  2. Kenyon Cynthia, If birds can fly, why can't we? Homeotic genes and evolution, 10.1016/0092-8674(94)90288-7
  3. Gehring Walter J., Qian Yan Qiu, Billeter Martin, Furukubo-Tokunaga Katsuo, Schier Alexander F., Resendez-Perez Diana, Affolter Markus, Otting Gottfried, Wüthrich Kurt, Homeodomain-DNA recognition, 10.1016/0092-8674(94)90292-5
  4. Wolberger Cynthia, Homeodomain interactions, 10.1016/s0959-440x(96)80096-0
  5. Hanes Steven D., Brent Roger, DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9, 10.1016/0092-8674(89)90063-9
  6. Ades Sarah E., Sauer Robert T., Differential DNA-binding specificity of the engrailed homeodomain: The role of residue 50, 10.1021/bi00197a022
  7. Stepchenko A., Cysteine 50 of the POU H domain determines the range of targets recognized by POU proteins, 10.1093/nar/25.14.2847
  8. Treisman Jessica, Harris Esther, Wilson David, Desplan Claude, The homeodomain: A new face for the helix-turn-helix?, 10.1002/bies.950140302
  9. Rastegar, Biochem. J., 334, 565 (1998)
  10. Depiereux Eric, Feytmans Ernest, MATCH-BOX: a fundamentally new algorithm for the simultaneous alignment of several protein sequences, 10.1093/bioinformatics/8.5.501
  11. Depiereux Eric, Baudoux Guy, Briffeuil Pascal, Reginster Isabelle, De Bolle Xavier, Vinals Carla, Feytmans Ernest, Match-Box_server: a multiple sequence alignment tool placing emphasis on reliability, 10.1093/bioinformatics/13.3.249
  12. Jacquemin Patrick, Martial Joseph A., Davidson Irwin, Human TEF-5 Is Preferentially Expressed in Placenta and Binds to Multiple Functional Elements of the Human Chorionic Somatomammotropin-B Gene Enhancer, 10.1074/jbc.272.20.12928
  13. Lawrence Peter A., Morata Gines, Homeobox genes: Their function in Drosophila segmentation and pattern formation, 10.1016/0092-8674(94)90289-5
  14. Xiao Jia Hao, Davidson Irwin, Matthes Hans, Garnier Jean-Marie, Chambon Pierre, Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1, 10.1016/0092-8674(91)90088-g
  15. Landry, Dev. Biol., 15, 247 (1997)
  16. Rausa Francisco, Samadani Uzma, Ye Honggang, Lim Lorena, Fletcher Colin F., Jenkins Nancy A., Copeland Neal G., Costa Robert H., The Cut-Homeodomain Transcriptional Activator HNF-6 Is Coexpressed with Its Target Gene HNF-3β in the Developing Murine Liver and Pancreas, 10.1006/dbio.1997.8744
  17. Altschul S, Basic Local Alignment Search Tool, 10.1006/jmbi.1990.9999
  18. Bürglin T. R. (1994) in Guidebook to the Homeobox Genes, ed Duboule D. (Oxford University Press, Oxford), pp 25–71.
  19. Muragaki Y., Mundlos S., Upton J., Olsen B. R., Altered Growth and Branching Patterns in Synpolydactyly Caused by Mutations in HOXD13, 10.1126/science.272.5261.548
  20. Vaisse C., Kim J., Espinosa R., Le Beau M. M., Stoffel M., Pancreatic Islet Expression Studies and Polymorphic DNA Markers in the Genes Encoding Hepatocyte Nuclear Factor-3 , -3 , -3 , -4 , and -6, 10.2337/diab.46.8.1364
  21. Papadimitrakopoulou, Clin. Cancer Res., 4, 539 (1998)
  22. Warburg Mette, Sjö Ole, Tranebjaerg Lisbeth, Fledelius Hans C., Deletion mapping of a retinal cone-rod dystrophy: Assignment to 18q211, 10.1002/ajmg.1320390309
  23. Furukawa Takahisa, Morrow Eric M, Cepko Constance L, Crx, a Novel otx-like Homeobox Gene, Shows Photoreceptor-Specific Expression and Regulates Photoreceptor Differentiation, 10.1016/s0092-8674(00)80439-0
  24. Krumlauf Robb, Hox genes in vertebrate development, 10.1016/0092-8674(94)90290-9
  25. Freund Carol L, Gregory-Evans Cheryl Y, Furukawa Takahisa, Papaioannou Myrto, Looser Jens, Ploder Lynda, Bellingham James, Ng David, Herbrick Jo-Anne S, Duncan Alessandra, Scherer Stephen W, Tsui Lap-Chee, Loutradis-Anagnostou Aphrodite, Jacobson Samuel G, Cepko Constance L, Bhattacharya Shomi S, McInnes Roderick R, Cone-Rod Dystrophy Due to Mutations in a Novel Photoreceptor-Specific Homeobox Gene (CRX) Essential for Maintenance of the Photoreceptor, 10.1016/s0092-8674(00)80440-7
  26. Samadani, Mol. Cell. Biol., 16, 6273 (1996)
  27. Kuo Calvin J., Conley Pamela B., Chen Lei , Sladek Frances M., Darnell James E., Crabtree Gerald R., A transcriptional hierarchy involved in mammalian cell-type specification, 10.1038/355457a0
  28. Bulla, Mol. Cell. Biol., 14, 7086 (1994)
  29. Cereghini, FASEB J., 10, 267 (1996)
  30. Späth, Mol. Cell. Biol., 17, 1913 (1997)
  31. Späth Gerald F., Weiss Mary C., Hepatocyte Nuclear Factor 4 Provokes Expression of Epithelial Marker Genes, Acting As a Morphogen in Dedifferentiated Hepatoma Cells, 10.1083/jcb.140.4.935
  32. Duncan S. A., Regulation of a Transcription Factor Network Required for Differentiation and Metabolism, 10.1126/science.281.5377.692
  33. .
  34. Blochlinger Karen, Bodmer Rolf, Jack Joseph, Jan Lily Yeh, Jan Yuh Nung, Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila, 10.1038/333629a0
  35. Harada, J. Biol. Chem., 269, 2062 (1994)
  36. Andres V, Chiara M D, Mahdavi V, A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins., 10.1101/gad.8.2.245
  37. Lannoy Vincent J., Bürglin Thomas R., Rousseau Guy G., Lemaigre Frédéric P., Isoforms of Hepatocyte Nuclear Factor-6 Differ in DNA-binding Properties, Contain a Bifunctional Homeodomain, and Define the New ONECUT Class of Homeodomain Proteins, 10.1074/jbc.273.22.13552
  38. Lemaigre F. P., Durviaux S. M., Truong O., Lannoy V. J., Hsuan J. J., Rousseau G. G., Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain., 10.1073/pnas.93.18.9460
Bibliographic reference Jacquemin, Patrick ; Lannoy, Vincent ; Rousseau, Guy ; Lemaigre, Frédéric. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. In: Journal of Biological Chemistry, Vol. 274, no. 5, p. 2665-2671 (1999)
Permanent URL http://hdl.handle.net/2078.1/21595