Rastegar, Mojgan
[UCL]
Lemaigre, Frédéric
[UCL]
Rousseau, Guy
[UCL]
Growth hormone (GH) controls gene expression in liver. Recent work suggests that this can result in part from the stimulation by GH of the synthesis of liver-specific transcription factors, one of which is HNF-6. The liver-specific factors HNF-4 and C/EBP alpha respectively stimulate and inhibit transcription of the hnf 6 gene. Upon GH stimulation, the affinity of HNF-4 for the hnf 6 promoter is increased and the binding of C/EBP alpha is decreased. GH therefore controls hnf 6 by a combination of stimulatory and derepressive mechanisms. On the other hand, HNF-6 stimulates transcription of the hnf 3beta and hnf 4 genes, the stimulation of hnf 4 resulting most likely from the GH-induced increase in HNF-6 concentration. We conclude that in liver GH is likely to control the synthesis of a whole set of proteins whose genes are regulated by a GH-sensitive network of transcription factors, which regulate each other by feed-back and autoregulatory loops.
Bibliographic reference |
Rastegar, Mojgan ; Lemaigre, Frédéric ; Rousseau, Guy. Control of gene expression by growth hormone in liver: key role of a network of transcription factors. In: Molecular and Cellular Endocrinology, Vol. 164, no. 1-2, p. 1-4 (2000) |
Permanent URL |
http://hdl.handle.net/2078.1/21591 |