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Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver.

Bibliographic reference Briançon, Nadège ; Bailly, Alain ; Clotman, Frédéric ; Jacquemin, Patrick ; Lemaigre, Frédéric ; et. al. Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver.. In: The Journal of biological chemistry, Vol. 279, no. 32, p. 33398-408 (2004)
Permanent URL http://hdl.handle.net/2078.1/21584
  1. J. Cell Sci., 111, 2411 (1998)
  2. Sladek F M, Zhong W M, Lai E, Darnell J E, Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily., 10.1101/gad.4.12b.2353
  3. Späth Gerald F., Weiss Mary C., Hepatocyte Nuclear Factor 4 Provokes Expression of Epithelial Marker Genes, Acting As a Morphogen in Dedifferentiated Hepatoma Cells, 10.1083/jcb.140.4.935
  4. Sladek, F. M., and Seidel, S. D. (2001) in Nuclear Receptors and Genetic Disease (Burris, T. P., and McCabe, E. R. B., eds) pp. 309-361, Academic Press, London
  5. Hayhurst G. P., Lee Y.-H., Lambert G., Ward J. M., Gonzalez F. J., Hepatocyte Nuclear Factor 4  (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis, 10.1128/mcb.21.4.1393-1403.2001
  6. Inoue Yusuke, Hayhurst Graham P., Inoue Junko, Mori Masataka, Gonzalez Frank J., Defective Ureagenesis in Mice Carrying a Liver-specific Disruption of Hepatocyte Nuclear Factor 4α (HNF4α) : HNF4α REGULATES ORNITHINE TRANSCARBAMYLASE IN VIVO , 10.1074/jbc.m203126200
  7. Hadzopoulou-Cladaras Margarita, Kistanova Elena, Evagelopoulou Catherine, Zeng Shengyou, Cladaras Christos, Ladias John A. A., Functional Domains of the Nuclear Receptor Hepatocyte Nuclear Factor 4, 10.1074/jbc.272.1.539
  8. Hata Shingo, Tsukamoto Toshiro, Osumi Takashi, A novel isoform of rat hepatocyte nuclear factor 4 (HNF-4), 10.1016/0167-4781(92)90080-j
  9. Nakhei H., Lingott A., Lemm I., Ryffel G. U., An alternative splice variant of the tissue specific transcription factor HNF4  predominates in undifferentiated murine cell types, 10.1093/nar/26.2.497
  10. Thomas H., A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young, 10.1093/hmg/10.19.2089
  11. Zhong W, Mirkovitch J, Darnell J E, Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression., 10.1128/mcb.14.11.7276
  12. Duncan S. A., Manova K., Chen W. S., Hoodless P., Weinstein D. C., Bachvarova R. F., Darnell J. E., Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst., 10.1073/pnas.91.16.7598
  13. Torres-Padilla Maria Elena, Sladek Frances M., Weiss Mary C., Developmentally Regulated N-terminal Variants of the Nuclear Receptor Hepatocyte Nuclear Factor 4α Mediate Multiple Interactions through Coactivator and Corepressor-Histone Deacetylase Complexes, 10.1074/jbc.m207545200
  14. Torres-Padilla Maria Elena, Fougère-Deschatrette Catherine, Weiss Mary C, Expression of HNF4α isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3′ end splicing, 10.1016/s0925-4773(01)00521-4
  15. Ryffel G., Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences, 10.1677/jme.0.0270011
  16. Yamagata Kazuya, Furuta Hiroto, Oda Naohisa, Kaisaki Pamela J., Menzel Stephan, Cox Nancy J., Fajans Stefan S., Signorini Stefano, Stoffel Markus, Bell Graeme I., Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1), 10.1038/384458a0
  17. Boj S. F., Parrizas M., Maestro M. A., Ferrer J., A transcription factor regulatory circuit in differentiated pancreatic cells, 10.1073/pnas.241349398
  18. Eeckhoute J., Moerman E., Bouckenooghe T., Lukoviak B., Pattou F., Formstecher P., Kerr-Conte J., Vandewalle B., Laine B., Hepatocyte Nuclear Factor 4α Isoforms Originated from the P1 Promoter Are Expressed in Human Pancreatic β-Cells and Exhibit Stronger Transcriptional Potentials than P2 Promoter-Driven Isoforms, 10.1210/en.2002-0024
  19. Lehto M., Bitzen P. O., Isomaa B., Wipemo C., Wessman Y., Forsblom C., Tuomi T., Taskinen M. R., Groop L., Mutation in the HNF-4alpha gene affects insulin secretion and triglyceride metabolism, 10.2337/diabetes.48.2.423
  20. Shih D. Q., Dansky H. M., Fleisher M., Assmann G., Fajans S. S., Stoffel M., Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels, 10.2337/diabetes.49.5.832
  21. Bailly A., An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors, 10.1093/nar/29.17.3495
  22. Hatzis P., Talianidis I., Regulatory Mechanisms Controlling Human Hepatocyte Nuclear Factor 4  Gene Expression, 10.1128/mcb.21.21.7320-7330.2001
  23. Taraviras Stavros, Paula Monaghan A., Schütz Günther, Kelsey Gavin, Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis, 10.1016/0925-4773(94)90017-5
  24. Amicone L., Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes, 10.1093/emboj/16.3.495
  25. Cell Growth Differ., 1, 519 (1990)
  26. Coon H. G., Weiss M. C., A QUANTITATIVE COMPARISON OF FORMATION OF SPONTANEOUS AND VIRUS-PRODUCED VIABLE HYBRIDS, 10.1073/pnas.62.3.852
  27. Cancer Res., 36, 4224 (1976)
  28. Efrat S., Linde S., Kofod H., Spector D., Delannoy M., Grant S., Hanahan D., Baekkeskov S., Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene., 10.1073/pnas.85.23.9037
  29. Pontoglio M, Faust D M, Doyen A, Yaniv M, Weiss M C, Hepatocyte nuclear factor 1alpha gene inactivation impairs chromatin remodeling and demethylation of the phenylalanine hydroxylase gene., 10.1128/mcb.17.9.4948
  30. Church G. M., Gilbert W., Genomic sequencing., 10.1073/pnas.81.7.1991
  31. Chirgwin John M., Przybyla Alan E., MacDonald Raymond J., Rutter William J., Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, 10.1021/bi00591a005
  32. Anal. Biochem., 162, 156 (1987)
  33. Lemaigre F. P., Durviaux S. M., Truong O., Lannoy V. J., Hsuan J. J., Rousseau G. G., Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain., 10.1073/pnas.93.18.9460
  34. Chen W S, Manova K, Weinstein D C, Duncan S A, Plump A S, Prezioso V R, Bachvarova R F, Darnell J E, Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos., 10.1101/gad.8.20.2466
  35. Maeda Y., Repression of Hepatocyte Nuclear Factor 4  by Tumor Suppressor p53: Involvement of the Ligand-Binding Domain and Histone Deacetylase Activity, 10.1210/me.16.2.402
  36. Faust D M, Catherin A M, Barbaux S, Belkadi L, Imaizumi-Scherrer T, Weiss M C, The activity of the highly inducible mouse phenylalanine hydroxylase gene promoter is dependent upon a tissue-specific, hormone-inducible enhancer., 10.1128/mcb.16.6.3125
  37. Jacquemin Patrick, Lannoy Vincent J., Rousseau Guy G., Lemaigre Frédéric P., OC-2, a Novel Mammalian Member of the ONECUT Class of Homeodomain Transcription Factors Whose Function in Liver Partially Overlaps with That of Hepatocyte Nuclear Factor-6, 10.1074/jbc.274.5.2665
  38. EMBO J., 10, 1445 (1991)
  39. Chouard Tanguy, Blumenfeld Marta, Bach Ingolf, Vandekerckhove Joël, Cereghini Silvia, Yaniv Moshe, A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain, 10.1093/nar/18.19.5853
  40. Jiang Guoqiang, Sladek Frances M., The DNA Binding Domain of Hepatocyte Nuclear Factor 4 Mediates Cooperative, Specific Binding to DNA and Heterodimerization with the Retinoid X Receptor α, 10.1074/jbc.272.2.1218
  41. de Wet J R, Wood K V, DeLuca M, Helinski D R, Subramani S, Firefly luciferase gene: structure and expression in mammalian cells., 10.1128/mcb.7.2.725
  42. Cereghini S, Blumenfeld M, Yaniv M, A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells., 10.1101/gad.2.8.957
  43. Watt A, HNF4: A central regulator of hepatocyte differentiation and function, 10.1053/jhep.2003.50273
  44. Development, 116, 783 (1992)
  45. Development, 124, 279 (1997)
  46. Ott Marie-Odile, Rey-Campos Javier, Cereghini Sylvia, Yaniv Moshe, vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression, 10.1016/0925-4773(91)90071-d
  47. Landry Claire, Clotman Frédéric, Hioki Takeshi, Oda Hiroaki, Picard Jacques J., Lemaigre Frédéric P., Rousseau Guy G., HNF-6 Is Expressed in Endoderm Derivatives and Nervous System of the Mouse Embryo and Participates to the Cross-Regulatory Network of Liver-Enriched Transcription Factors, 10.1006/dbio.1997.8757
  48. Lannoy Vincent J., Bürglin Thomas R., Rousseau Guy G., Lemaigre Frédéric P., Isoforms of Hepatocyte Nuclear Factor-6 Differ in DNA-binding Properties, Contain a Bifunctional Homeodomain, and Define the New ONECUT Class of Homeodomain Proteins, 10.1074/jbc.273.22.13552
  49. Vanhorenbeeck Vinciane, Jacquemin Patrick, Lemaigre Frédéric P., Rousseau Guy G., OC-3, a Novel Mammalian Member of the ONECUT Class of Transcription Factors, 10.1006/bbrc.2002.6760
  50. Jacquemin Patrick, Pierreux Christophe E., Fierens Sébastien, van Eyll Jonathan M., Lemaigre Frédéric P., Rousseau Guy G., Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2, 10.1016/s1567-133x(03)00110-8
  51. Rausa Francisco, Samadani Uzma, Ye Honggang, Lim Lorena, Fletcher Colin F., Jenkins Nancy A., Copeland Neal G., Costa Robert H., The Cut-Homeodomain Transcriptional Activator HNF-6 Is Coexpressed with Its Target Gene HNF-3β in the Developing Murine Liver and Pancreas, 10.1006/dbio.1997.8744
  52. Jacquemin P., Durviaux S. M., Jensen J., Godfraind C., Gradwohl G., Guillemot F., Madsen O. D., Carmeliet P., Dewerchin M., Collen D., Rousseau G. G., Lemaigre F. P., Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3, 10.1128/mcb.20.12.4445-4454.2000
  53. Greengard O., CYTOMORPHOMETRY OF DEVELOPING RAT LIVER AND ITS APPLICATION TO ENZYMIC DIFFERENTIATION, 10.1083/jcb.52.2.261
  54. Gill Grace, Ptashne Mark, Negative effect of the transcriptional activator GAL4, 10.1038/334721a0
  55. Tasset Diane, Tora Laszlo, Fromental Catherine, Scheer Elisabeth, Chambon Pierre, Distinct classes of transcriptional activating domains function by different mechanisms, 10.1016/0092-8674(90)90394-t
  56. Genes Dev., 14, 464 (2000)
  57. Odom D. T., Control of Pancreas and Liver Gene Expression by HNF Transcription Factors, 10.1126/science.1089769
  58. Landry Josette-Renée, Mager Dixie L., Wilhelm Brian T., Complex controls: the role of alternative promoters in mammalian genomes, 10.1016/j.tig.2003.09.014
  59. Zhu Y., Qi C., Korenberg J. R., Chen X. N., Noya D., Rao M. S., Reddy J. K., Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms., 10.1073/pnas.92.17.7921
  60. Parrado A., Retinoic acid receptor alpha1 variants, RARalpha1DeltaB and RARalpha1DeltaBC, define a new class of nuclear receptor isoforms, 10.1093/nar/29.24.4901
  61. FASEB J., 10, 267 (1996)
  62. Duncan Stephen A, Mechanisms controlling early development of the liver, 10.1016/s0925-4773(02)00328-3
  63. Friedman Alan D, Transcriptional regulation of granulocyte and monocyte development, 10.1038/sj.onc.1205324
  64. Gellon Gabriel, McGinnis William, Shaping animal body plans in development and evolution by modulation of Hox expression patterns, 10.1002/(sici)1521-1878(199802)20:2<116::aid-bies4>3.0.co;2-r
  65. Zhang Samuel Shao-Min, Fu Xin-Yuan, Barnstable Colin J, Molecular Aspects of Vertebrate Retinal Development, 10.1385/mn:26:2-3:137
  66. Hansen Sara K., Párrizas Marcelina, Jensen Maria L., Pruhova Stepanka, Ek Jakob, Boj Sylvia F., Johansen Anders, Maestro Miguel A., Rivera Francisca, Eiberg Hans, Andel Michal, Lebl Jan, Pedersen Oluf, Ferrer Jorge, Hansen Torben, Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function, 10.1172/jci200215085
  67. Parviz Fereshteh, Li Jixuan, Kaestner Klaus H., Duncan Stephen A., Generation of a conditionally null allele ofhnf4?, 10.1002/gene.10058
  68. Development, 129, 1819 (2002)
  69. Coffinier Catherine, Barra Jacqueline, Babinet Charles, Yaniv Moshe, Expression of the vHNF1/HNF1β homeoprotein gene during mouse organogenesis, 10.1016/s0925-4773(99)00221-x
  70. Development, 126, 4795 (1999)
  71. Silberg Debra G., Swain Gary P., Suh Eun Ran, Traber Peter G., Cdx1 and Cdx2 expression during intestinal development, 10.1053/gast.2000.18142
  72. Boudreau François, Rings Edmond H. H. M., van Wering Herbert M., Kim Richard K., Swain Gary P., Krasinski Stephen D., Moffett Jennifer, Grand Richard J., Suh Eun Ran, Traber Peter G., Hepatocyte Nuclear Factor-1α, GATA-4, and Caudal Related Homeodomain Protein Cdx2 Interact Functionally to Modulate Intestinal Gene Transcription : IMPLICATION FOR THE DEVELOPMENTAL REGULATION OF THE SUCRASE-ISOMALTASE GENE, 10.1074/jbc.m204622200
  73. MITCHELMORE Cathy, TROELSEN Jesper T., SPODSBERG Nikolaj, SJÖSTRÖM Hans, NORÉN Ove, Interaction between the homeodomain proteins Cdx2 and HNF1α mediates expression of the lactase-phlorizin hydrolase gene, 10.1042/0264-6021:3460529
  74. Maestro Miguel A., Boj Sylvia F., Luco Reini F., Pierreux Christophe E., Cabedo Judit, Servitja Joan M., German Michael S., Rousseau Guy G., Lemaigre Frédéric P., Ferrer Jorge, Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas, 10.1093/hmg/ddg355
  75. Ktistaki E., Modulation of Hepatic Gene Expression by Hepatocyte Nuclear Factor 1 , 10.1126/science.277.5322.109
  76. Chou W.-C., Mechanism of a Transcriptional Cross Talk between Transforming Growth Factor-beta -regulated Smad3 and Smad4 Proteins and Orphan Nuclear Receptor Hepatocyte Nuclear Factor-4, 10.1091/mbc.e02-07-0375
  77. Lee Y.-K., Dell H., Dowhan D. H., Hadzopoulou-Cladaras M., Moore D. D., The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression, 10.1128/mcb.20.1.187-195.2000
  78. Parviz Fereshteh, Matullo Christine, Garrison Wendy D, Savatski Laura, Adamson John W, Ning Gang, Kaestner Klaus H, Rossi Jennifer M, Zaret Kenneth S, Duncan Stephen A, Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis, 10.1038/ng1175
  79. Petrescu Anca D., Payne Harold R., Boedecker Amy, Chao Hsu, Hertz Rachel, Bar-Tana Jacob, Schroeder Friedhelm, Kier Ann B., Physical and Functional Interaction of Acyl-CoA-binding Protein with Hepatocyte Nuclear Factor-4α, 10.1074/jbc.m303858200
  80. Quandt Kerstin, Frech Kornelie, Karas Holger, Wingender Edgar, Werner Thomas, Matlnd and Matlnspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data, 10.1093/nar/23.23.4878
  81. Hatzis Pantelis, Talianidis Iannis, Dynamics of Enhancer-Promoter Communication during Differentiation-Induced Gene Activation, 10.1016/s1097-2765(02)00786-4
  82. SZPIRER C., SZPIRER J., A Mouse Hepatoma Cell Line which Secretes Several Serum Proteins Including Albumin and α-foetoprotein, 10.1111/j.1432-0436.1975.tb01446.x
  83. Current Protocols in Molecular Biology, 1, 48.1 (1992)
  84. Eeckhoute J., Hepatocyte Nuclear Factor 4  enhances the Hepatocyte Nuclear Factor 1 -mediated activation of transcription, 10.1093/nar/gkh581
  85. Späth G F, Weiss M C, Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells., 10.1128/mcb.17.4.1913