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Frequency and predictors of cholesterol target attainment in patients with stable coronary heart disease in Belgium: results from the Dyslipidemia International Study II (DYSIS II CHD)

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Hermans, Michel [UCL] Gevaert, Sofie Descamps, Olivier [UCL] Missault, Luc Gillot, Bernard Gitt, Anselm

(eng) OBJECTIVES: To document the frequency and predictors of low-density lipoprotein cholesterol (LDL-C) target value attainment among patients with coronary heart disease (CHD) in Belgium. METHODS: The second Dyslipidemia International Study (DYSIS II) was an observational study of the prevalence of dyslipidemias and lipid target value attainment. Patients in this analysis were aged ≥ 18, had documented CHD, and had a full lipid profile. Use of lipid-lowering therapy (LLT), lipid profile, and LDL-C target value attainment (< 70 mg/dL) were assessed cross-sectionally at the enrollment visit. The distribution of LLTs was assessed among treated patients. Multivariate logistic regression was used to identify variables predictive of LDL-C target value attainment in treated patients. RESULTS: We identified 409 patients with CHD in Belgium, 387 (94.6%) of whom were on LLT at the time of the lipid profile. Among treated patients, the rate of LDL-C target value attainment was 40.6%, and statin monotherapy was the most commonly used LLT (79.3%). Among users of statin monotherapy or combination therapy, simvastatin was the most commonly used treatment (41.6% of patients). Diabetes was associated with higher odds of LDL-C target value attainment (OR 2.29, 95% CI 1.33-3.93), and female gender was associated with lower odds (OR 0.48, 95% CI 0.24-0.97). CONCLUSION: Rates of LDL-C target value attainment are low in patients with CHD in Belgium. Intensifying statin therapy or combining it with non-statins is essential in Belgian patients for optimal LDL-C reduction.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2019
Language Anglais
Journal information "Acta Clinica Belgica" - Vol. 74, no. 6, p. 399-404 (2019)
Peer reviewed yes
Publisher Tayor & Francis ((United Kingdom) Abingdon)
issn 1784-3286
e-issn 2295-3337
Publication status Publié
Affiliations UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition
UCL - (SLuc) Service de cardiologie
UCL - (SLuc) Service d'endocrinologie et de nutrition
Keywords Belgium ; LDL-cholesterol ; Cardiovascular disease ; Dyslipidemias ; Statins
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Bibliographic reference Hermans, Michel ; Gevaert, Sofie ; Descamps, Olivier ; Missault, Luc ; Gillot, Bernard ; et. al. Frequency and predictors of cholesterol target attainment in patients with stable coronary heart disease in Belgium: results from the Dyslipidemia International Study II (DYSIS II CHD). In: Acta Clinica Belgica, Vol. 74, no. 6, p. 399-404 (2019)
Permanent URL http://hdl.handle.net/2078.1/215755