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Wide variety of genotypes and geographic origins of hepatitis B virus in Belgian children.

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Liu, H F Sokal, Etienne [UCL] Goubau, Patrick [UCL]

BACKGROUND: Belgium is a country with low endemicity for hepatitis B virus (HBV) infection. Few data are available on genotypes or serotypes of HBV among infected children. METHODS: The S region of the hepatitis B virus genome was amplified and sequenced in 23 children treated with interferon-alpha in Belgium. Nucleotide sequences were aligned and compared with other known sequences in a phylogenetic analysis. RESULTS: A high stability of the S gene was observed during treatment. Four genotypes were represented in this sample of Belgian patients (A, B, D, and E), reflecting the geographic diversity of origins. CONCLUSIONS: In this series, the wide variety of geographic origins is confirmed by the molecular characteristics of HBV. In Belgium, HBV infection of children is currently essentially an imported infection.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2001
Journal information "Journal of Pediatric Gastroenterology and Nutrition" - Vol. 32, no. 3, p. 274-277 (2001)
Peer reviewed yes
Publisher Lippincott Williams & Wilkins (Philadelphia)
issn 0277-2116
e-issn 1536-4801
Publication status Publié
Affiliations UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie
UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique
UCL - (SLuc) Centre de pathologie anorectale de l'enfant
UCL - (SLuc) Centre de thérapie tissulaire et cellulaire
UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
UCL - (SLuc) Service de microbiologie
MESH Subject Antiviral Agents - therapeutic use ; Base Sequence ; Belgium ; Child ; Genotype ; Hepatitis B - drug therapy - virology ; Hepatitis B virus - classification - genetics ; Humans ; Interferon Alfa-2b - therapeutic use ; Molecular Sequence Data ; Phylogeny ; Polymerase Chain Reaction ; Sequence Analysis, DNA ; Serotyping
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Bibliographic reference Liu, H F ; Sokal, Etienne ; Goubau, Patrick. Wide variety of genotypes and geographic origins of hepatitis B virus in Belgian children.. In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 32, no. 3, p. 274-277 (2001)
Permanent URL http://hdl.handle.net/2078.1/21543