Chekin, Fereshteh
[Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol/ Iran]
Myshin, Vladyslav
[Université de Lille, CNRS, Centrale Lille, ISEN, Université de Valenciennes, Lille/France]
Ye, Ran
[UCL]
Melinte, Sorin
[UCL]
Singh, Santosh K.
[Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune/India]
Kurungot, Sreekumar
[Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune/India]
Boukherroub, Rabah
[Université de Lille, CNRS, Centrale Lille, ISEN, Université de Valenciennes, UMR 8520-IEMN, Lille, France]
Szunerits, Sabine
[Université de Lille, CNRS, Centrale Lille, ISEN, Université de Valenciennes, UMR 8520-IEMN, Lille, France]
Doxorubicin (DOX), an anthracycline molecule, is currently one of the most widely used anticancer drugs in clinics. Systematic treatment of patients with DOX is known to be accompanied by several unpleasant side effects due to the toxicity of the drug. Thus, monitoring of DOX concentration in serum samples has become increasingly important to avoid side effects and ensure therapeutic efficiency. In this study, we discuss the construction of a disposable electrochemical sensor for the direct monitoring of DOX in clinical blood samples. The sensor is based on coating a gold electrode in a flexible integrated electrode construct formed on polyimide sheets using photolithography, with nitrogen-doped reduced graphene oxide (N-rGO) suspended in chitosan. Under optimized conditions, a linear relationship between the oxidative peak current and the concentration of DOX in the range of 0.010–15 μM with a detection limit of 10 nM could be achieved. The sensor was adapted to monitor DOX in serum samples of patients under anticancer treatment.
Berry G., Billingham M., Alderman E., Richardson P., Torti F., Lum B., Patek A., Martin F. J., The use of cardiac biopsy to demonstrate reduced cardiotoxicity in AIDS Kaposi's sarcoma patients treated with pegylated liposomal doxorubicin, 10.1023/a:1008216430806
Charrois Gregory J.R, Allen Theresa M, Drug release rate influences the pharmacokinetics, biodistribution, therapeutic activity, and toxicity of pegylated liposomal doxorubicin formulations in murine breast cancer, 10.1016/j.bbamem.2004.03.006
Lotem Michal, Hubert Ayala, Lyass Olga, Goldenhersh Michael A., Ingber Arieh, Peretz Tamar, Gabizon Alberto, Skin Toxic Effects of Polyethylene Glycol–Coated Liposomal Doxorubicin, 10.1001/archderm.136.12.1475
McGowan John V, Chung Robin, Maulik Angshuman, Piotrowska Izabela, Walker J Malcolm, Yellon Derek M, Anthracycline Chemotherapy and Cardiotoxicity, 10.1007/s10557-016-6711-0
Pai Vinita B., Nahata Milap C., Cardiotoxicity of Chemotherapeutic Agents : Incidence, Treatment and Prevention, 10.2165/00002018-200022040-00002
Shah Mansi, Bourner Luke, Ali Shariq, Al-Enazy Sanaalarab, Youssef Menatallah, Fisler Morgan, Rytting Erik, HPLC Method Development for Quantification of Doxorubicin in Cell Culture and Placental Perfusion Media, 10.3390/separations5010009
ARNOLD R, Quantification of Doxorubicin and metabolites in rat plasma and small volume tissue samples by liquid chromatography/electrospray tandem mass spectroscopy, 10.1016/j.jchromb.2004.04.030
Motlagh Najme Sadat Hosseini, Parvin Parviz, Ghasemi Fatemah, Atyabi Fatemeh, Fluorescence properties of several chemotherapy drugs: doxorubicin, paclitaxel and bleomycin, 10.1364/boe.7.002400
Chaney Edward N., Baldwin Richard P., Voltammetric determination of doxorubicin in urine by adsorptive preconcentration and flow injection analysis, 10.1016/s0003-2670(00)81637-2
Hajian Reza, Tayebi Zahra, Shams Nafiseh, Fabrication of an electrochemical sensor for determination of doxorubicin in human plasma and its interaction with DNA, 10.1016/j.jpha.2016.07.005
Hashemzadeh Nastaran, Hasanzadeh Mohammad, Shadjou Nasrin, Eivazi-Ziaei Jamal, Khoubnasabjafari Maryam, Jouyban Abolghasem, Graphene quantum dot modified glassy carbon electrode for the determination of doxorubicin hydrochloride in human plasma, 10.1016/j.jpha.2016.03.003
Rezaei Behzad, Askarpour Neda, Ensafi Ali A., A novel sensitive doxorubicin impedimetric immunosensor based on a specific monoclonal antibody–gold nanoaprticle–sol–gel modified electrode, 10.1016/j.talanta.2013.11.017
Vajdle Olga, Zbiljić Jasmina, Tasić Bojan, Jović Danica, Guzsvány Valéria, Djordjevic Aleksandar, Voltammetric behavior of doxorubicin at a renewable silver-amalgam film electrode and its determination in human urine, 10.1016/j.electacta.2014.03.124
He Lijie, Sarkar Sujoy, Barras Alexandre, Boukherroub Rabah, Szunerits Sabine, Mandler Daniel, Electrochemically stimulated drug release from flexible electrodes coated electrophoretically with doxorubicin loaded reduced graphene oxide, 10.1039/c7cc00381a
Kaur Manpreet, Kaur Manmeet, Sharma Virender K., Nitrogen-doped graphene and graphene quantum dots: A review onsynthesis and applications in energy, sensors and environment, 10.1016/j.cis.2018.07.001
Chekin Fereshteh, Vasilescu Alina, Jijie Roxana, Singh Santosh K., Kurungot Sreekumar, Iancu Mădălina, Badea Gabriela, Boukherroub Rabah, Szunerits Sabine, Sensitive electrochemical detection of cardiac troponin I in serum and saliva by nitrogen-doped porous reduced graphene oxide electrode, 10.1016/j.snb.2018.01.215
Vasilescu Alina, Ye Ran, Boulahneche Samia, Lamraoui Sabrina, Jijie Roxana, Medjram Mohamed Salah, Gáspár Szilveszter, Singh Santosh K., Kurungot Sreekumar, Melinte Sorin, Boukherroub Rabah, Szunerits Sabine, Porous reduced graphene oxide modified electrodes for the analysis of protein aggregation. Part 2: Application to the analysis of calcitonin containing pharmaceutical formulation, 10.1016/j.electacta.2018.02.038
Singh Santosh K., Dhavale Vishal M., Boukherroub Rabah, Kurungot Sreekumar, Szunerits Sabine, N-doped porous reduced graphene oxide as an efficient electrode material for high performance flexible solid-state supercapacitor, 10.1016/j.apmt.2016.10.002
Hung Wei-Song, Chang Sue-Min, Lecaros Rumwald Leo G., Ji Yan-Li, An Quan-Fu, Hu Chien-Chieh, Lee Kueir-Rarn, Lai Juin-Yih, Fabrication of hydrothermally reduced graphene oxide/chitosan composite membranes with a lamellar structure on methanol dehydration, 10.1016/j.carbon.2017.02.088
Qi Jianing, Yao Ping, He Fen, Yu Chuiliang, Huang Chong, Nanoparticles with dextran/chitosan shell and BSA/chitosan core—Doxorubicin loading and delivery, 10.1016/j.ijpharm.2010.03.063
Janes Kevin A., Fresneau Marie P., Marazuela Ana, Fabra Angels, Alonso Marı́a José, Chitosan nanoparticles as delivery systems for doxorubicin, 10.1016/s0168-3659(01)00294-2
Soleymani Jafar, Hasanzadeh Mohammad, Shadjou Nasrin, Khoubnasab Jafari Maryam, Gharamaleki Jalil Vaez, Yadollahi Mehdi, Jouyban Abolghasem, A new kinetic–mechanistic approach to elucidate electrooxidation of doxorubicin hydrochloride in unprocessed human fluids using magnetic graphene based nanocomposite modified glassy carbon electrode, 10.1016/j.msec.2016.01.003
Peng Anlin, , Application of a Disposable Doxorubicin Sensor for Direct Determination of Clinical Drug Concentration in Patient Blood, 10.20964/2016.07.38
Bibliographic reference
Chekin, Fereshteh ; Myshin, Vladyslav ; Ye, Ran ; Melinte, Sorin ; Singh, Santosh K. ; et. al. Graphene-modified electrodes for sensing doxorubicin hydrochloride in human plasma. In: Analytical and Bioanalytical Chemistry, Vol. 411, p. 1509-1516 (2019)