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Exposure of hairdressers to aromatic diamines: an interventional study confirming the protective effect of adequate glove use.

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Geens, Tom Aerts, Evelyne Borguet, Marc Haufroid, Vincent [UCL] Godderis, Lode

OBJECTIVES: Many hairdressers leave their profession due to health problems, including occupational hand eczema, which has been associated with skin exposure to sensitising hair dye components such as paraphenylenediamine (PPD) and paratoluenediamine (PTD). Since the use of protective gloves is advised but without the short-term effect being known, our main goal was to attribute a significant biomarker reduction to adequate glove use, in a real work situation. METHODS: 11 hairdressers were studied over 2 weeks. In the first week, they worked as usual and (re)used their gloves. Thereafter, we intervened to improve glove use during the second week. In both weeks, workplace exposure data were collected through observations, and systemic exposure was quantified by biomonitoring of PPD and PTD. The effect of improved glove use and other exposure determinants was studied through mixed models analysis. RESULTS: We showed that improved glove use significantly reduced mean PTD concentrations from 24.1 before to 4.2 µg/g creatinine after the intervention (n=11, third day postshift). In addition, mean PTD concentrations increased during the first week (14 times elevated after three consecutive shifts), but not during the second week. For PPD, no effect of improved glove use and no accumulation effect were detected. CONCLUSIONS: Our study is the first to deliver evidence for a significant reduction in systemic exposure to PTD through improved glove use. Disposable gloves should never be reused. PTD biomonitoring is shown to be a practical tool to quantify recent dermal exposure to oxidative hair dye components.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "Occupational and Environmental Medicine" - Vol. 73, no.4, p. 221-228 (2016)
Peer reviewed yes
Publisher BMJ Group ((United Kingdom) London)
issn 1351-0711
e-issn 1470-7926
Publication status Publié
Affiliations UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology
UCL - (SLuc) Service de biochimie médicale
UCL - (SLuc) Centre de toxicologie clinique
MESH Subject Adolescent ; Adult ; Beauty Culture ; Dermatitis, Occupational ; Diamines ; Female ; Gloves, Protective ; Hair Dyes ; Health Promotion ; Humans ; Male ; Occupational Exposure ; Occupations ; Work ; Young Adult
Keywords glove use ; paraphenylenediamine ; paratoluenediamine
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Bibliographic reference Geens, Tom ; Aerts, Evelyne ; Borguet, Marc ; Haufroid, Vincent ; Godderis, Lode. Exposure of hairdressers to aromatic diamines: an interventional study confirming the protective effect of adequate glove use.. In: Occupational and Environmental Medicine, Vol. 73, no.4, p. 221-228 (2016)
Permanent URL http://hdl.handle.net/2078.1/213415