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Mid-term results of a randomized trial of tricuspid annuloplasty for less-than-severe functional tricuspid regurgitation at the time of mitral valve surgery†.

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Pettinari, Matteo [UCL] de Kerchove, Laurent [UCL] Lazam, Siham [UCL] Pasquet, Agnes [UCL] Gerber, Bernhard [UCL] Vanoverschelde, Jean-Louis [UCL] El Khoury, Gebrine [UCL]

(eng) OBJECTIVES: The optimal management of functional tricuspid regurgitation (FTR) in the setting of mitral valve operations remains controversial. The current practice is both centre specific and surgeon specific with guidelines based on non-randomized data. A prospective randomized trial was performed to evaluate the worth of less-than-severe FTR repair during mitral valve procedures. METHODS: A single-centre randomized study was designed to allocate patients with less-than-severe FTR undergoing mitral valve surgery to be prophylactically treated with or without tricuspid valve annuloplasty (TVP- or TVP+). These patients were analysed using longitudinal cardiopulmonary exercise capacity, echocardiographic follow-up and cardiac magnetic resonance. The primary outcome was freedom from more than or equal to moderate tricuspid regurgitation with vena contracta ≥4 mm. Secondary outcomes were maximal oxygen uptake and right ventricular (RV) dimension and function. RESULTS: A total of 53 patients were allocated to receive concomitant TVP+, and 53 patients were treated conservatively (TVP-). At 5 years, tricuspid regurgitation was observed to be greater than mild in 10 patients in the TVP- group and no patients in the TVP+ group (P < 0.01). Maximal oxygen uptake, RV basal diameter, end-diastolic diameter and end-systolic diameter and fractional area changes were similar in both groups. Cardiac magnetic resonance confirmed no differences in RV end-diastolic volume, RV end-systolic volume and RV ejection fraction. CONCLUSIONS: This single-centre prospective randomized trial demonstrated that prophylactic tricuspid annuloplasty irrespective of annular dilatation at the time of mitral surgery reduced the recurrence of moderate or severe FTR at 5-year follow-up and reduced the pulmonary pressure. Nevertheless, the functional capacity, the RV function and the RV dimension remained similar.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2019
Language Anglais
Journal information "European journal of cardio-thoracic surgery" - Vol. 55, no. 5, p. 851-858 (2019)
Peer reviewed yes
Publisher Oxford University Press ((United Kingdom) Oxford)
issn 1010-7940
e-issn 1873-734X
Publication status Publié
Affiliations UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire
UCL - (SLuc) Service de chirurgie cardiovasculaire et thoracique
UCL - (SLuc) Service de cardiologie
Keywords Mitral valve ; Regurgitation ; Tricuspid valve
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Bibliographic reference Pettinari, Matteo ; de Kerchove, Laurent ; Lazam, Siham ; Pasquet, Agnes ; Gerber, Bernhard ; et. al. Mid-term results of a randomized trial of tricuspid annuloplasty for less-than-severe functional tricuspid regurgitation at the time of mitral valve surgery†.. In: European journal of cardio-thoracic surgery, Vol. 55, no. 5, p. 851-858 (2019)
Permanent URL http://hdl.handle.net/2078.1/209944