User menu

Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations.

Bibliographic reference Bensellam, Mohammed ; Van Lommel, L. ; Overbergh, L. ; Schuit, F. C. ; Jonas, Jean-Christophe. Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations.. In: Diabetologia, Vol. 52, no. 3, p. 463-76 (2009)
Permanent URL http://hdl.handle.net/2078.1/20964
  1. Quintens R, Hendrickx N, Lemaire K, Schuit F (2008) Why expression of some genes is disallowed in beta-cells. Biochem Soc Trans 36:300–305
  2. Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A (2001) β-cell adaptation and decompensation during the progression of diabetes. Diabetes 50(Suppl 1):S154–S159
  3. Blume N, Skouv J, Larsson LI, Holst JJ, Madsen OD (1995) Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis. J Clin Invest 96:2227–2235
  4. Leahy JL (2000) Detrimental effects of chronic hyperglycemia on the pancreatic β-cell. In: LeRoith D, Taylor SI, Olefsky JM (eds) Diabetes mellitus: a fundamental and clinical text. Lippincott-Williams & Wilkins, Philadelphia, pp 115–124
  5. Hinke SA, Hellemans K, Schuit FC (2004) Plasticity of the β cell insulin secretory competence: preparing the pancreatic β cell for the next meal. J Physiol 558:369–380
  6. Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S, Eizirik DL (2005) Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54(Suppl 2):S97–S107
  7. Gilon P, Jonas JC, Henquin JC (1994) Culture duration and conditions affect the oscillations of cytoplasmic calcium concentration induced by glucose in mouse pancreatic islets. Diabetologia 37:1007–1014
  8. Flamez D, Berger V, Kruhoffer M, Orntoft T, Pipeleers D, Schuit FC (2002) Critical role for cataplerosis via citrate in glucose-regulated insulin release. Diabetes 51:2018–2024
  9. Ling Z, Kiekens R, Mahler T et al (1996) Effects of chronically elevated glucose levels on the functional properties of rat pancreatic β-cells. Diabetes 45:1774–1782
  10. Khaldi MZ, Guiot Y, Gilon P, Henquin JC, Jonas JC (2004) Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for one week in high glucose. Am J Physiol Endocrinol Metab 287:E207–E217
  11. Efanova IB, Zaitsev SV, Zhivotovsky B et al (1998) Glucose and tolbutamide induce apoptosis in pancreatic β-cells—a process dependent on intracellular Ca2+ concentration. J Biol Chem 273:33501–33507
  12. Hoorens A, van de Casteele M, Klöppel G, Pipeleers DG (1996) Glucose promotes survival of rat pancreatic β cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98:1568–1574
  13. Van de Casteele M, Kefas BA, Cai Y et al (2003) Prolonged culture in low glucose induces apoptosis of rat pancreatic β-cells through induction of c-myc. Biochem Biophys Res Commun 312:937–944
  14. Elouil H, Bensellam M, Guiot Y et al (2007) Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets. Diabetologia 50:1442–1452
  15. Jonas JC, Laybutt DR, Steil GM et al (2001) High glucose stimulates early response gene c-Myc expression in rat pancreatic β cells. J Biol Chem 276:35375–35381
  16. Jonas JC, Guiot Y, Rahier J, Henquin JC (2003) Haeme-oxygenase 1 expression in rat pancreatic beta-cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP. Diabetologia 46:1234–1244
  17. Webb GC, Akbar MS, Zhao C, Steiner DF (2000) Expression profiling of pancreatic β cells: glucose regulation of secretory and metabolic pathway genes. Proc Natl Acad Sci U S A 97:5773–5778
  18. Schuit F, Flamez D, de Vos A, Pipeleers D (2002) Glucose-regulated gene expression maintaining the glucose-responsive state of β-cells. Diabetes 51(Suppl 3):S326–S332
  19. Shalev A, Pise-Masison CA, Radonovich M et al (2002) Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFb signaling pathway. Endocrinology 143:3695–3698
  20. Zhou YP, Marlen K, Palma JF et al (2003) Overexpression of repressive cAMP response element modulators in high glucose and fatty acid-treated rat islets. A common mechanism for glucose toxicity and lipotoxicity? J Biol Chem 278:51316–51323
  21. Ma Z, Portwood N, Brodin D, Grill V, Bjorklund A (2007) Effects of diazoxide on gene expression in rat pancreatic islets are largely linked to elevated glucose and potentially serve to enhance β-cell sensitivity. Diabetes 56:1095–1106
  22. Sekine N, Cirulli V, Regazzi R et al (1994) Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cells. Potential role in nutrient sensing. J Biol Chem 269:4895–4902
  23. Pascal SM, Guiot Y, Pelengaris S, Khan M, Jonas JC (2008) Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets. Am J Physiol Endocrinol Metab 295:E92–E102
  24. Susini S, Roche E, Prentki M, Schlegel W (1998) Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic b(INS-1) cells. FASEB J 12:1173–1182
  25. Chen J, Saxena G, Mungrue IN, Lusis AJ, Shalev A (2008) Thioredoxin-interacting protein: a critical link between glucose toxicity and β-cell apoptosis. Diabetes 57:938–944
  26. Greenman IC, Gomez E, Moore CE, Herbert TP (2007) Distinct glucose-dependent stress responses revealed by translational profiling in pancreatic β-cells. J Endocrinol 192:179–187
  27. Harding HP, Zhang Y, Zeng H et al (2003) An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11:619–633
  28. Maedler K, Spinas GA, Lehmann R et al (2001) Glucose induces β-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes 50:1683–1690
  29. Clark JE, Foresti R, Green CJ, Motterlini R (2000) Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress. Biochem J 348:615–619
  30. Li X, Chen H, Epstein PN (2004) Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species. J Biol Chem 279:765–771
  31. Bindokas VP, Kuznetsov A, Sreenan S, Polonsky KS, Roe MW, Philipson LH (2003) Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem 278:9796–9801
  32. Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H (2003) Glucose toxicity in β-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52:581–587
  33. Martens GA, Cai Y, Hinke S, Stange G, van de Casteele M, Pipeleers D (2005) Glucose suppresses superoxide generation in metabolically responsive pancreatic β cells. J Biol Chem 280:20389–20396
  34. Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, van de Casteele M (2007) Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. Free Radic Biol Med 42:64–78
  35. Lee AH, Iwakoshi NN, Glimcher LH (2003) XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23:7448–7459
  36. Draghici S, Khatri P, Bhavsar P, Shah A, Krawetz SA, Tainsky MA (2003) Onto-Tools, the toolkit of the modern biologist: Onto-Express, Onto-Compare, Onto-Design and Onto-Translate. Nucleic Acids Res 31:3775–3781
  37. Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR (2002) GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet 31:19–20
  38. Otonkoski T, Jiao H, Kaminen-Ahola N et al (2007) Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic β cells. Am J Hum Genet 81:467–474
  39. Vander Mierde D, Scheuner D, Quintens R et al (2006) Glucose activates a PP1 mediated signaling pathway to enhance overall translation in pancreatic β-cells. Endocrinology 148:609–617
  40. Plaisance V, Abderrahmani A, Perret-Menoud V, Jacquemin P, Lemaigre F, Regazzi R (2006) MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. J Biol Chem 281:26932–26942
  41. Diraison F, Ravier MA, Richards SK, Smith RM, Shimano H, Rutter GA (2008) SREBP1 is required for the induction by glucose of pancreatic β-cell genes involved in glucose sensing. J Lipid Res 49:814–822
  42. Vikman J, Jimenez-Feltstrom J, Nyman P, Thelin J, Eliasson L (2008) Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol. FASEB J doi: 10.1096/fj.08-105734
  43. Wang H, Kouri G, Wollheim CB (2005) ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity. J Cell Sci 118:3905–3915
  44. Shimano H, Amemiya-Kudo M, Takahashi A, Kato T, Ishikawa M, Yamada N (2007) Sterol regulatory element-binding protein-1c and pancreatic β-cell dysfunction. Diabetes Obes Metab 9(Suppl 2):133–139
  45. Roche E, Assimacopoulos-Jeannet F, Witters LA et al (1997) Induction by glucose of genes coding for glycolytic enzymes in a pancreatic β-cell line (INS-1). J Biol Chem 272:3091–3098
  46. Yang J, Wong RK, Park M et al (2006) Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic β-cells. Diabetes 55:193–201
  47. Seufert J, Weir GC, Habener JF (1998) Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus. J Clin Invest 101:2528–2539
  48. Yan W, Frank CL, Korth MJ et al (2002) Control of PERK eIF2a kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci U S A 99:15920–15925
  49. Kang SJ, Wang S, Hara H et al (2000) Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J Cell Biol 149:613–622
  50. Elouil H, Cardozo AK, Eizirik DL, Henquin JC, Jonas JC (2005) High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkB. Diabetologia 48:496–505