Frédéric, Christophe J.-M.
Cornil, Jérôme
Vandamme, Mathilde
Dumitrescu, Lidia
Tikad, Abdellatif
Robiette, Raphaël
[UCL]
Vincent, Stéphane P.
Highly (Z)-diastereoselective approaches for the synthesis of trifluoromethylated exo-glycals by copper and photoredox catalysis are described. These complementary reactions are applicable to a wide range of methylene exo-glycals generated from the corresponding pyranoses and furanoses and give trifluoromethylated compounds under mild conditions in moderate to good yields. DFT calculations have allowed a rationalization of the observed (Z)-stereoselectivity.
Bibliographic reference |
Frédéric, Christophe J.-M. ; Cornil, Jérôme ; Vandamme, Mathilde ; Dumitrescu, Lidia ; Tikad, Abdellatif ; et. al. Highly (Z)-Diastereoselective Synthesis of Trifluoromethylated exo-Glycals via Photoredox and Copper Catalysis. In: Organic Letters, Vol. 20, no.21, p. 6769-6773 (2018) |
Permanent URL |
http://hdl.handle.net/2078.1/204624 |