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Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN.

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Valassi, Elena Feelders, Richard Maiter, Dominique [UCL] Chanson, Philippe Yaneva, Maria ERCUSYN Study Group

Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR-CS). Data from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analysed. At baseline, HRQoL did not differ between PIT-CS (n = 293) and ADR-CS (n = 120) on both EuroQoL and CushingQoL. Total CushingQoL score in PIT-CS and ADR-CS was 41 ± 18 and 44 ± 20, respectively (P = .7). At long-time follow-up (>1 year after treatment) total CushingQoL score was however lower in PIT-CS than ADR-CS (56 ± 20 vs 62 ± 23; P = .045). In a regression analysis, after adjustment for baseline age, gender, remission status, duration of active CS, glucocorticoid dependency and follow-up time, no association was observed between aetiology and HRQoL. Remission was associated with better total CushingQoL score (P < .001), and older age at diagnosis with worse total score (P = .01). Depression at diagnosis was associated with worse total CushingQoL score at the last follow-up (P < .001). PIT-CS patients had poorer HRQoL than ADR-CS at long-term follow-up, despite similar baseline scoring. After adjusting for remission status, no interaetiology differences in HRQoL scoring were found. Age and presence of depression at diagnosis of CS may be potential predictors of worse HRQoL regardless of CS aetiology.

Document type Article de périodique (Journal article)
Access type Accès libre
Publication date 2018
Language Anglais
Journal information "Clinical endocrinology" - Vol. 88, no.6, p. 787-798 (2018)
e-issn 1365-2265
Publication status Publié
Affiliation UCL - (SLuc) Service d'endocrinologie et de nutrition
Keywords Cushing's syndrome ; ERCUSYN ; health-related quality of life
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  1. Tiemensma Jitske, Biermasz Nienke R., Middelkoop Huub A. M., van der Mast Roos C., Romijn Johannes A., Pereira Alberto M., Increased Prevalence of Psychopathology and Maladaptive Personality Traits after Long-Term Cure of Cushing’s Disease, 10.1210/jc.2010-0512
  2. Webb Susan M, Crespo Iris, Santos Alicia, Resmini Eugenia, Aulinas Anna, Valassi Elena, MANAGEMENT OF ENDOCRINE DISEASE: Quality of life tools for the management of pituitary disease, 10.1530/eje-17-0041
  3. De Bucy Charlotte, Guignat Laurence, Niati Tanya, Bertherat Jérôme, Coste Joel, Health-related quality of life of patients with hypothalamic–pituitary–adrenal axis dysregulations: a cohort study, 10.1530/eje-17-0048
  4. Dorn, J Clin Endocrinol Metab, 82, 912 (1997)
  5. Lindsay John R., Nansel Tonya, Baid Smita, Gumowski Julie, Nieman Lynnette K., Long-Term Impaired Quality of Life in Cushing’s Syndrome despite Initial Improvement after Surgical Remission, 10.1210/jc.2005-1058
  6. Andela Cornelie D., Scharloo Margreet, Pereira Alberto M., Kaptein Ad A., Biermasz Nienke R., Quality of life (QoL) impairments in patients with a pituitary adenoma: a systematic review of QoL studies, 10.1007/s11102-015-0636-7
  7. Pikkarainen L., Sane T., Reunanen A., The survival and well-being of patients treated for Cushing's syndrome, 10.1046/j.1365-2796.1999.00483.x
  8. Nagesser Suresh K., van Seters Arnoud P., Kievit Job, Hermans Jo, Krans H. Michiel J., van de Velde Cornelis J.H., Long-term Results of Total Adrenalectomy for Cushing's Disease, 10.1007/s002689910020
  9. Lindholm, J Clin Endocrinol Metab, 86, 117 (2001)
  10. Hawn Mary T., Cook David, Deveney Clifford, Sheppard Brett C., Quality of life after laparoscopic bilateral adrenalectomy for Cushing's disease, 10.1067/msy.2002.128482
  11. van Aken M. O., Pereira A. M., Biermasz N. R., van Thiel S. W., Hoftijzer H. C., Smit J. W. A., Roelfsema F., Lamberts S. W. J., Romijn J. A., Quality of Life in Patients after Long-Term Biochemical Cure of Cushing’s Disease, 10.1210/jc.2004-1375
  12. Sonino Nicoletta, Bonnini Stefano, Fallo Francesco, Boscaro Marco, Fava Giovanni A., Personality characteristics and quality of life in patients treated for Cushing's syndrome, 10.1111/j.1365-2265.2006.02462.x
  13. Thompson Sarah K., Hayman Amanda V., Ludlam William H., Deveney Clifford W., Loriaux D Lynn, Sheppard Brett C., Improved Quality of Life After Bilateral Laparoscopic Adrenalectomy for Cushing??s Disease : A 10-Year Experience, 10.1097/01.sla.0000251578.03883.2f
  14. van der Klaauw Agatha A., Kars Marleen, Biermasz Nienke R., Roelfsema Ferdinand, Dekkers Olaf M., Corssmit Eleonora P., van Aken Maarten O., Havekes Bas, Pereira Alberto M., Pijl Hanno, Smit Johannes W., Romijn Johannes A., Disease-specific impairments in quality of life during long-term follow-up of patients with different pituitary adenomas, 10.1111/j.1365-2265.2008.03288.x
  15. Milian Monika, Kreitschmann-Andermahr Ilonka, Siegel Sonja, Kleist Bernadette, Führer-Sakel Dagmar, Honegger Juergen, Buchfelder Michael, Psaras Tsambika, Validation of the Tuebingen CD-25 Inventory as a Measure of Postoperative Health-Related Quality of Life in Patients Treated for Cushing's Disease, 10.1159/000431022
  16. Valassi E, Crespo I, Keevil B G, Aulinas A, Urgell E, Santos A, Trainer P J, Webb S M, Affective alterations in patients with Cushing’s syndrome in remission are associated with decreased BDNF and cortisone levels, 10.1530/eje-16-0779
  17. Ragnarsson Oskar, Berglund Peter, Eder Derek N., Johannsson Gudmundur, Long-Term Cognitive Impairments and Attentional Deficits in Patients with Cushing's Disease and Cortisol-Producing Adrenal Adenoma in Remission, 10.1210/jc.2012-1945
  18. Tiemensma J., Kaptein A. A., Pereira A. M., Smit J. W. A., Romijn J. A., Biermasz N. R., Negative illness perceptions are associated with impaired quality of life in patients after long-term remission of Cushing's syndrome, 10.1530/eje-11-0307
  19. Valassi E., Santos A., Yaneva M., Toth M., Strasburger C. J., Chanson P., Wass J. A. H., Chabre O., Pfeifer M., Feelders R. A., Tsagarakis S., Trainer P. J., Franz H., Zopf K., Zacharieva S., Lamberts S. W. J., Tabarin A., Webb S. M., , The European Registry on Cushing's syndrome: 2-year experience. Baseline demographic and clinical characteristics, 10.1530/eje-11-0272
  20. Wagenmakers M. A. E. M., Netea-Maier R. T., Prins J. B., Dekkers T., den Heijer M., Hermus A. R. M. M., Impaired quality of life in patients in long-term remission of Cushing's syndrome of both adrenal and pituitary origin: a remaining effect of long-standing hypercortisolism?, 10.1530/eje-12-0308
  21. Webb S M, Badia X, Barahona M J, Colao A, Strasburger C J, Tabarin A, van Aken M O, Pivonello R, Stalla G, Lamberts S W J, Glusman J E, Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire, 10.1530/eje-07-0762
  22. Tiemensma Jitske, Depaoli Sarah, Felt John M, Using subscales when scoring the Cushing's quality of life questionnaire, 10.1530/eje-15-0640
  23. Valassi Elena, Franz Holger, Brue Thierry, Feelders Richard A, Netea-Maier Romana, Tsagarakis Stylianos, Webb Susan M, Yaneva Maria, Reincke Martin, Droste Michael, Komerdus Irina, Maiter Dominique, Kastelan Darko, Chanson Philippe, Pfeifer Marija, Strasburger Christian J, Tóth Miklós, Chabre Olivier, Tabarin Antoine, Krsek Michal, Fajardo Carmen, Bolanowski Marek, Santos Alicia, Wass John A H, Trainer Peter J, , Diagnostic tests for Cushing's syndrome differ from published guidelines: data from ERCUSYN, 10.1530/eje-16-0967
  24. EuroQol - a new facility for the measurement of health-related quality of life, 10.1016/0168-8510(90)90421-9
  25. Santos A., Resmini E., Martinez-Momblan M. A., Crespo I., Valassi E., Roset M., Badia X., Webb S. M., Psychometric performance of the CushingQoL questionnaire in conditions of real clinical practice, 10.1530/eje-12-0325
  26. Andela C. D., van Haalen F. M., Ragnarsson O., Papakokkinou E., Johannsson G., Santos A., Webb S. M., Biermasz N. R., van der Wee N. J. A., Pereira A. M., MECHANISMS IN ENDOCRINOLOGY: Cushing's syndrome causes irreversible effects on the human brain: a systematic review of structural and functional magnetic resonance imaging studies, 10.1530/eje-14-1101
  27. Ragnarsson Oskar, Stomby Andreas, Dahlqvist Per, Evang Johan A., Ryberg Mats, Olsson Tommy, Bollerslev Jens, Nyberg Lars, Johannsson Gudmundur, Decreased prefrontal functional brain response during memory testing in women with Cushing’s syndrome in remission, 10.1016/j.psyneuen.2017.05.010
  28. Ragnarsson O., Johannsson G., MANAGEMENT OF ENDOCRINE DISEASE: Cushing's syndrome: a structured short- and long-term management plan for patients in remission, 10.1530/eje-13-0534
  29. Sippel Rebecca S., Elaraj Dina M., Kebebew Electron, Lindsay Sheila, Tyrrell J. Blake, Duh Quan-Yang, Waiting for change: Symptom resolution after adrenalectomy for Cushing's syndrome, 10.1016/j.surg.2008.08.024
  30. Nieman Lynnette K., Biller Beverly M. K., Findling James W., Murad M. Hassan, Newell-Price John, Savage Martin O., Tabarin Antoine, Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline, 10.1210/jc.2015-1818
  31. Atkinson A. Brew, Kennedy Adele, Wiggam M. Ivan, McCance David R., Sheridan Brian, Long-term remission rates after pituitary surgery for Cushing's disease: the need for long-term surveillance, 10.1111/j.1365-2265.2005.02380.x
Bibliographic reference Valassi, Elena ; Feelders, Richard ; Maiter, Dominique ; Chanson, Philippe ; Yaneva, Maria ; et. al. Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN.. In: Clinical endocrinology, Vol. 88, no.6, p. 787-798 (2018)
Permanent URL http://hdl.handle.net/2078.1/201715