User menu

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes.

Bibliographic reference Zhu, Jingjing ; Powis de Tenbossche, Céline G ; Cané, Stefania ; Colau, Didier ; van Baren, Nicolas ; et. al. Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes.. In: Nature Communications, Vol. 8, p. 1404 (2017)
Permanent URL
  1. Coulie Pierre G., Van den Eynde Benoît J., van der Bruggen Pierre, Boon Thierry, Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy, 10.1038/nrc3670
  2. Huijbers Ivo J., Krimpenfort Paul, Chomez Patrick, van der Valk Martin A., Song Ji-Ying, Inderberg-Suso Else-Marit, Schmitt-Verhulst Anne-Marie, Berns Anton, Van den Eynde Benoît J., An Inducible Mouse Model of Melanoma Expressing a Defined Tumor Antigen, 10.1158/0008-5472.can-05-3216
  3. Wehbe Maria, Soudja Saïdi M., Mas Amandine, Chasson Lionel, Guinamard Rodolphe, de Tenbossche Céline Powis, Verdeil Grégory, Van den Eynde Benoît, Schmitt-Verhulst Anne-Marie, Epithelial-Mesenchymal-Transition-Like and TGFβ Pathways Associated with Autochthonous Inflammatory Melanoma Development in Mice, 10.1371/journal.pone.0049419
  4. Soudja S. M., Wehbe M., Mas A., Chasson L., de Tenbossche C. P., Huijbers I., Van den Eynde B., Schmitt-Verhulst A. M., Tumor-Initiated Inflammation Overrides Protective Adaptive Immunity in an Induced Melanoma Model in Mice, 10.1158/0008-5472.can-09-4354
  5. Hugo Willy, Zaretsky Jesse M., Sun Lu, Song Chunying, Moreno Blanca Homet, Hu-Lieskovan Siwen, Berent-Maoz Beata, Pang Jia, Chmielowski Bartosz, Cherry Grace, Seja Elizabeth, Lomeli Shirley, Kong Xiangju, Kelley Mark C., Sosman Jeffrey A., Johnson Douglas B., Ribas Antoni, Lo Roger S., Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma, 10.1016/j.cell.2016.02.065
  6. Naslund T. I., Uyttenhove C., Nordstrom E. K. L., Colau D., Warnier G., Jondal M., Van den Eynde B. J., Liljestrom P., Comparative Prime-Boost Vaccinations Using Semliki Forest Virus, Adenovirus, and ALVAC Vectors Demonstrate Differences in the Generation of a Protective Central Memory CTL Response against the P815 Tumor, 10.4049/jimmunol.178.11.6761
  7. Lurquin Christophe, Van Pel Aline, Mariamé Bernard, De Plaen Etienne, Szikora Jean-Pierre, Janssens Catherine, Reddehase Matthias J., Lejeune Joseph, Boon Thierry, Structure of the gene of tum− transplantation antigen P91A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cells, 10.1016/0092-8674(89)90844-1
  8. Willimsky Gerald, Czéh Melinda, Loddenkemper Christoph, Gellermann Johanna, Schmidt Karin, Wust Peter, Stein Harald, Blankenstein Thomas, Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness, 10.1084/jem.20072016
  9. Willimsky Gerald, Blankenstein Thomas, Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance, 10.1038/nature03954
  10. Shanker A., Auphan-Anezin N., Chomez P., Giraudo L., Eynde B. V. d., Schmitt-Verhulst A.-M., Thymocyte-Intrinsic Genetic Factors Influence CD8 T Cell Lineage Commitment and Affect Selection of a Tumor-Reactive TCR, 10.4049/jimmunol.172.8.5069
  11. Griffin Robert J., Williams Brent W., Bischof John C., Olin Michael, Johnson Gary L., Lee Brian W., Use of a Fluorescently Labeled Poly-Caspase Inhibitor for in Vivo Detection of Apoptosis Related to Vascular-Targeting Agent Arsenic Trioxide for Cancer Therapy, 10.1177/153303460700600609
  12. Spranger S., Spaapen R. M., Zha Y., Williams J., Meng Y., Ha T. T., Gajewski T. F., Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells, 10.1126/scitranslmed.3006504
  13. Chen Jiao, Feng Yun, Lu Libing, Wang Hui, Dai Lina, Li Yan, Zhang Ping, Interferon-γ-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway, 10.1016/j.imbio.2011.10.016
  14. Pardoll Drew M., The blockade of immune checkpoints in cancer immunotherapy, 10.1038/nrc3239
  15. van Baren N., Van den Eynde B. J., Tumoral Immune Resistance Mediated by Enzymes That Degrade Tryptophan, 10.1158/2326-6066.cir-15-0095
  16. Keir Mary E., Butte Manish J., Freeman Gordon J., Sharpe Arlene H., PD-1 and Its Ligands in Tolerance and Immunity, 10.1146/annurev.immunol.26.021607.090331
  17. Xu, X., Fu, X. Y., Plate, J. & Chong, A. S. IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression. Cancer Res. 58, 2832–2837 (1998).
  18. Bertrand F., Rochotte J., Colacios C., Montfort A., Tilkin-Mariame A.-F., Touriol C., Rochaix P., Lajoie-Mazenc I., Andrieu-Abadie N., Levade T., Benoist H., Segui B., Blocking Tumor Necrosis Factor   Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma, 10.1158/0008-5472.can-14-2524
  19. Gabrilovich Dmitry I., Ostrand-Rosenberg Suzanne, Bronte Vincenzo, Coordinated regulation of myeloid cells by tumours, 10.1038/nri3175
  20. Youn Je-In, Gabrilovich Dmitry I., The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity, 10.1002/eji.201040895
  21. Chun Eunyoung, Lavoie Sydney, Michaud Monia, Gallini Carey Ann, Kim Jason, Soucy Genevieve, Odze Robert, Glickman Jonathan N., Garrett Wendy S., CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function, 10.1016/j.celrep.2015.06.024
  22. Rodriguez P. C., Ernstoff M. S., Hernandez C., Atkins M., Zabaleta J., Sierra R., Ochoa A. C., Arginase I-Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes, 10.1158/0008-5472.can-08-1921
  23. Youn Je-In, Collazo Michelle, Shalova Irina N., Biswas Subhra K., Gabrilovich Dmitry I., Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice, 10.1189/jlb.0311177
  24. Stromnes I. M., Greenberg P. D., Hingorani S. R., Molecular Pathways: Myeloid Complicity in Cancer, 10.1158/1078-0432.ccr-13-0866
  25. Viola Antonella, Sarukhan Adelaida, Bronte Vincenzo, Molon Barbara, The pros and cons of chemokines in tumor immunology, 10.1016/
  26. Kumar Vinit, Patel Sima, Tcyganov Evgenii, Gabrilovich Dmitry I., The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment, 10.1016/
  27. Youn Je-In, Kumar Vinit, Collazo Michelle, Nefedova Yulia, Condamine Thomas, Cheng Pingyan, Villagra Alejandro, Antonia Scott, McCaffrey Judith C, Fishman Mayer, Sarnaik Amod, Horna Pedro, Sotomayor Eduardo, Gabrilovich Dmitry I, Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer, 10.1038/ni.2526
  28. Waring Paul, Müllbacher Arno, Cell death induced by the Fas/Fas ligand pathway and its role in pathology, 10.1046/j.1440-1711.1999.00837.x
  29. Maher Stephen, Toomey Deirdre, Condron Claire, Bouchier-Hayes David, Activation-induced cell death: The controversial role of Fas and Fas ligand in immune privilege and tumour counterattack, 10.1046/j.1440-1711.2002.01068.x
  30. De Cruz Panfilo O. La, Specht Charles S., McLean Ian W., Lymphocytic infiltration in uveal malignant melanoma, 10.1002/1097-0142(19900101)65:1<112::aid-cncr2820650123>;2-x
  31. Whelchel, J. C., Farah, S. E., McLean, I. W. & Burnier, M. N. Immunohistochemistry of infiltrating lymphocytes in uveal malignant melanoma. Invest. Ophthalmol. Vis. Sci. 34, 2603–2606 (1993).
  32. Webster W. Scott, Lohse Christine M., Thompson R. Houston, Dong Haidong, Frigola Xavier, Dicks Demetrius L., Sengupta Shomik, Frank Igor, Leibovich Bradley C., Blute Michael L., Cheville John C., Kwon Eugene D., Mononuclear cell infiltration in clear-cell renal cell carcinoma independently predicts patient survival, 10.1002/cncr.21951
  33. Hahne M., Rimoldi D., Schroter M., Romero P., Schreier M., French L. E., Schneider P., Bornand T., Fontana A., Lienard D., Cerottini J.-C., Tschopp J., Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape, 10.1126/science.274.5291.1363
  34. Seino Ken-Ichiro, Kayagaki Nobuhiko, Okumura Ko, Yagita Hideo, Antitumor effect of locally produced CD95 ligand, 10.1038/nm0297-165
  35. Arai H., Gordon D., Nabel E. G., Nabel G. J., Gene transfer of Fas ligand induces tumor regression in vivo, 10.1073/pnas.94.25.13862
  36. Restifo Nicholas P., Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape, 10.1038/74955
  37. Alderson M. R., Fas ligand mediates activation-induced cell death in human T lymphocytes, 10.1084/jem.181.1.71
  38. O’ Reilly Lorraine A., Tai Lin, Lee Lily, Kruse Elizabeth A., Grabow Stephanie, Fairlie W. Douglas, Haynes Nicole M., Tarlinton David M., Zhang Jian-Guo, Belz Gabrielle T., Smyth Mark J., Bouillet Philippe, Robb Lorraine, Strasser Andreas, Membrane-bound Fas ligand only is essential for Fas-induced apoptosis, 10.1038/nature08402
  39. Ryan Aideen E., Shanahan Fergus, O'Connell Joe, Houston Aileen M., Addressing the “Fas Counterattack” Controversy: Blocking Fas Ligand Expression Suppresses Tumor Immune Evasion of Colon CancerIn vivo, 10.1158/0008-5472.can-05-1462
  40. Motz Gregory T, Santoro Stephen P, Wang Li-Ping, Garrabrant Tom, Lastra Ricardo R, Hagemann Ian S, Lal Priti, Feldman Michael D, Benencia Fabian, Coukos George, Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors, 10.1038/nm.3541
  41. Klebanoff Christopher A., Scott Christopher D., Leonardi Anthony J., Yamamoto Tori N., Cruz Anthony C., Ouyang Claudia, Ramaswamy Madhu, Roychoudhuri Rahul, Ji Yun, Eil Robert L., Sukumar Madhusudhanan, Crompton Joseph G., Palmer Douglas C., Borman Zachary A., Clever David, Thomas Stacy K., Patel Shashankkumar, Yu Zhiya, Muranski Pawel, Liu Hui, Wang Ena, Marincola Francesco M., Gros Alena, Gattinoni Luca, Rosenberg Steven A., Siegel Richard M., Restifo Nicholas P., Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy, 10.1172/jci81217
  42. Trapani Joseph A., Smyth Mark J., Functional significance of the perforin/granzyme cell death pathway, 10.1038/nri911
  43. Listopad J. J., Kammertoens T., Anders K., Silkenstedt B., Willimsky G., Schmidt K., Kuehl A. A., Loddenkemper C., Blankenstein T., Fas expression by tumor stroma is required for cancer eradication, 10.1073/pnas.1218295110
  44. Watanabe-Fukunaga Rie, Brannan Camilynn I., Copeland Neal G., Jenkins Nancy A., Nagata Shigekazu, Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis, 10.1038/356314a0
  45. Singer Gary G., Abbas Abul K., The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice, 10.1016/1074-7613(94)90067-1
  46. Nagata Shigekazu, Suda Takashi, Fas and Fas ligand: lpr and gld mutations, 10.1016/0167-5699(95)80069-7
  47. Roths J. B., A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice, 10.1084/jem.159.1.1
  48. Uyttenhove C., Escape of mouse mastocytoma P815 after nearly complete rejection is due to antigen-loss variants rather than immunosuppression, 10.1084/jem.157.3.1040
  49. Lethé Bernard, Van den Eynde Beno??t, Van Pel Aline, Corradin Giampietro, Boon Thierry, Mouse tumor rejection antigens P815A and P815B : Two epitopes carried by a single peptide, 10.1002/eji.1830220916
  50. Gajewski, T. F., Renauld, J.-C., Van Pel, A. & Boon, T. Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine anti-tumor cytolytic T lymphocytes in vitro. J. Immunol. 154, 5637–5648 (1995).
  51. Brändle Daniel, Bilsborough Janine, Rülicke Thomas, Uyttenhove Catherine, Boon Thierry, Van den Eynde Benoît J., The shared tumor-specific antigen encoded by mouse geneP1A is a target not only for cytolytic T lymphocytes but also for tumor rejection, 10.1002/(sici)1521-4141(199812)28:12<4010::aid-immu4010>;2-5
  52. Garçon N., Silvano J., Kuper C. F., Baudson N., Gérard C., Forster R., Segal L., Non-clinical safety evaluation of repeated intramuscular administration of the AS15 immunostimulant combined with various antigens in rabbits and cynomolgus monkeys : AS15 immunostimulant combined with various antigens in rabbits/monkeys, 10.1002/jat.3167
  53. Bilsborough J., Uyttenhove C., Colau D., Bousso P., Libert C., Weynand B., Boon T., Van den Eynde B. J., TNF-Mediated Toxicity After Massive Induction of Specific CD8+ T Cells Following Immunization of Mice with a Tumor-Specific Peptide, 10.4049/jimmunol.169.6.3053
  54. Huijbers I. J., Soudja S. M., Uyttenhove C., Buferne M., Inderberg-Suso E.-M., Colau D., Pilotte L., Powis de Tenbossche C. G., Chomez P., Brasseur F., Schmitt-Verhulst A.-M., Van den Eynde B. J., Minimal Tolerance to a Tumor Antigen Encoded by a Cancer-Germline Gene, 10.4049/jimmunol.1002612
  55. Van den Eynde B., The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice, 10.1084/jem.173.6.1373