User menu

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia.

Bibliographic reference Pinho, Andreia V ; Bensellam, Mohammed ; Wauters, Elke ; Rees, Maxine ; Giry-Laterriere, Marc ; et. al. Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia.. In: PLoS One, Vol. 10, p. e0128012 (2015)
Permanent URL http://hdl.handle.net/2078/192289
  1. Vetere Amedeo, Choudhary Amit, Burns Sean M., Wagner Bridget K., Targeting the pancreatic β-cell to treat diabetes, 10.1038/nrd4231
  2. Boutant Marie, Cantó Carles, SIRT1 metabolic actions: Integrating recent advances from mouse models, 10.1016/j.molmet.2013.10.006
  3. Herranz Daniel, Serrano Manuel, SIRT1: recent lessons from mouse models, 10.1038/nrc2962
  4. Hubbard Basil P., Sinclair David A., Small molecule SIRT1 activators for the treatment of aging and age-related diseases, 10.1016/j.tips.2013.12.004
  5. Bordone Laura, Motta Maria Carla, Picard Frederic, Robinson Ashley, Jhala Ulupi S, Apfeld Javier, McDonagh Thomas, Lemieux Madeleine, McBurney Michael, Szilvasi Akos, Easlon Erin J, Lin Su-Ju, Guarente Leonard, Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells, 10.1371/journal.pbio.0040031
  6. Luu L., Dai F. F., Prentice K. J., Huang X., Hardy A. B., Hansen J. B., Liu Y., Joseph J. W., Wheeler M. B., The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing, 10.1007/s00125-013-2946-5
  7. Ramsey Kathryn Moynihan, Mills Kathryn F., Satoh Akiko, Imai Shin-ichiro, Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice, 10.1111/j.1474-9726.2007.00355.x
  8. Moynihan Kathryn A., Grimm Andrew A., Plueger Marie M., Bernal-Mizrachi Ernesto, Ford Eric, Cras-Méneur Corentin, Permutt M. Alan, Imai Shin-ichiro, Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice, 10.1016/j.cmet.2005.07.001
  9. Wang Rui-Hong, Xu Xiaoling, Kim Hyun-Seok, Xiao Zhen, Deng Chu-Xia, SIRT1 Deacetylates FOXA2 and Is Critical for Pdx1 Transcription and β-Cell Formation, 10.7150/ijbs.7529
  10. Xie Chen, Mao Xizeng, Huang Jiaju, Ding Yang, Wu Jianmin, Dong Shan, Kong Lei, Gao Ge, Li Chuan-Yun, Wei Liping, KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases, 10.1093/nar/gkr483
  11. Wauters E., Sanchez-Arevalo Lobo V. J., Pinho A. V., Mawson A., Herranz D., Wu J., Cowley M. J., Colvin E. K., Njicop E. N., Sutherland R. L., Liu T., Serrano M., Bouwens L., Real F. X., Biankin A. V., Rooman I., Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer, 10.1158/0008-5472.can-12-3359
  12. Thorens Bernard, GLUT2, glucose sensing and glucose homeostasis, 10.1007/s00125-014-3451-1
  13. Chan J. Y., Luzuriaga J., Bensellam M., Biden T. J., Laybutt D. R., Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in  -Cell Gene Expression and Progression to Diabetes, 10.2337/db12-0701
  14. Lee A.-H., Iwakoshi N. N., Glimcher L. H., XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response, 10.1128/mcb.23.21.7448-7459.2003
  15. Bensellam Mohammed, Laybutt D. Ross, Jonas Jean-Christophe, The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions, 10.1016/j.mce.2012.08.003
  16. Wang Rui-Hong, Sengupta Kundan, Li Cuiling, Kim Hyun-Seok, Cao Liu, Xiao Cuiying, Kim Sangsoo, Xu Xiaoling, Zheng Yin, Chilton Beverly, Jia Rong, Zheng Zhi-Ming, Appella Ettore, Wang Xin Wei, Ried Thomas, Deng Chu-Xia, Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice, 10.1016/j.ccr.2008.09.001
  17. McBurney M. W., Yang X., Jardine K., Hixon M., Boekelheide K., Webb J. R., Lansdorp P. M., Lemieux M., The Mammalian SIR2  Protein Has a Role in Embryogenesis and Gametogenesis, 10.1128/mcb.23.1.38-54.2003
  18. Wang Rui-Hong, Kim Hyun-Seok, Xiao Cuiying, Xu Xiaoling, Gavrilova Oksana, Deng Chu-Xia, Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance, 10.1172/jci46243
  19. Hingorani Sunil R., Petricoin Emanuel F., Maitra Anirban, Rajapakse Vinodh, King Catrina, Jacobetz Michael A., Ross Sally, Conrads Thomas P., Veenstra Timothy D., Hitt Ben A., Kawaguchi Yoshiya, Johann Don, Liotta Lance A., Crawford Howard C., Putt Mary E., Jacks Tyler, Wright Christopher V.E., Hruban Ralph H., Lowy Andrew M., Tuveson David A., Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse, 10.1016/s1535-6108(03)00309-x
  20. Laybutt D. R., Hawkins Y. C., Lock J., Lebet J., Sharma A., Bonner-Weir S., Weir G. C., Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats, 10.1007/s00125-007-0749-2
  21. Jonas Jean-Christophe, Sharma Arun, Hasenkamp Wendy, Ilkova Hasan, Patanè Giovanni, Laybutt Ross, Bonner-Weir Susan, Weir Gordon C., Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes, 10.1074/jbc.274.20.14112
  22. Li Y., Xu S., Giles A., Nakamura K., Lee J. W., Hou X., Donmez G., Li J., Luo Z., Walsh K., Guarente L., Zang M., Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver, 10.1096/fj.10-173492
  23. Lee A.-H., Heidtman K., Hotamisligil G. S., Glimcher L. H., Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion, 10.1073/pnas.1105564108
  24. Wang Feng-Ming, Chen Yi-Jiun, Ouyang Hong-Jiao, Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation, 10.1042/bj20101293
  25. Yulyaningsih Ernie, Loh Kim, Lin Shu, Lau Jackie, Zhang Lei, Shi Yanchuan, Berning Britt A., Enriquez Ronaldo, Driessler Frank, Macia Laurence, Khor Ee Cheng, Qi Yue, Baldock Paul, Sainsbury Amanda, Herzog Herbert, Pancreatic Polypeptide Controls Energy Homeostasis via Npy6r Signaling in the Suprachiasmatic Nucleus in Mice, 10.1016/j.cmet.2013.11.019