User menu

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.

Bibliographic reference Stockis, Julie ; Liénart, Stéphanie ; Colau, Didier ; Collignon, Amandine ; Nishimura, Stephen L ; et. al. Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.. In: Proceedings of the National academy of sciences of the United States of America, Vol. 114, no. 47, p. E10161-E10168 (2017)
Permanent URL http://hdl.handle.net/2078.1/189549
  1. Josefowicz Steven Z., Lu Li-Fan, Rudensky Alexander Y., Regulatory T Cells: Mechanisms of Differentiation and Function, 10.1146/annurev.immunol.25.022106.141623
  2. Robertson Ian B., Rifkin Daniel B., Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation, 10.1016/j.cytogfr.2013.06.003
  3. Campbell I. D., Humphries M. J., Integrin Structure, Activation, and Interactions, 10.1101/cshperspect.a004994
  4. Reed N. I., Jo H., Chen C., Tsujino K., Arnold T. D., DeGrado W. F., Sheppard D., The  v 1 integrin plays a critical in vivo role in tissue fibrosis, 10.1126/scitranslmed.aaa5094
  5. Munger John S, Huang Xiaozhu, Kawakatsu Hisaaki, Griffiths Mark J.D, Dalton Stephen L, Wu Jianfeng, Pittet Jean-François, Kaminski Naftali, Garat Chrystelle, Matthay Michael A, Rifkin Daniel B, Sheppard Dean, A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1, 10.1016/s0092-8674(00)80545-0
  6. Morris David G., Huang Xiaozhu, Kaminski Naftali, Wang Yanli, Shapiro Steven D., Dolganov Gregory, Glick Adam, Sheppard Dean, Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema, 10.1038/nature01413
  7. Ma Li-Jun, Yang Haichun, Gaspert Ariana, Carlesso Gianluca, Barty Melissa M., Davidson Jeffrey M., Sheppard Dean, Fogo Agnes B., Transforming Growth Factor-β-Dependent and -Independent Pathways of Induction of Tubulointerstitial Fibrosis in β6−/− Mice, 10.1016/s0002-9440(10)63486-4
  8. Pittet Jean-Francois, Griffiths Mark J.D., Geiser Tom, Kaminski Naftali, Dalton Stephen L., Huang Xiaozhu, Brown Lou Anne S., Gotwals Phillip J., Koteliansky Victor E., Matthay Michael A., Sheppard Dean, TGF-β is a critical mediator of acute lung injury, 10.1172/jci11963
  9. Wang Bruce, Dolinski Brian M., Kikuchi Noriko, Leone Diane R., Peters Marion G., Weinreb Paul H., Violette Shelia M., Bissell D. Montgomery, Role of αvβ6 integrin in acute biliary fibrosis, 10.1002/hep.21849
  10. Sugimoto Kotaro, Kudo Makoto, Sundaram Aparna, Ren Xin, Huang Katherine, Bernstein Xin, Wang Yanli, Raymond Wilfred W., Erle David J., Åbrink Magnus, Caughey George H., Huang Xiaozhu, Sheppard Dean, The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells, 10.1172/jci58815
  11. Travis Mark A., Reizis Boris, Melton Andrew C., Masteller Emma, Tang Qizhi, Proctor John M., Wang Yanli, Bernstein Xin, Huang Xiaozhu, Reichardt Louis F., Bluestone Jeffrey A., Sheppard Dean, Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice, 10.1038/nature06110
  12. Lacy-Hulbert A., Smith A. M., Tissire H., Barry M., Crowley D., Bronson R. T., Roes J. T., Savill J. S., Hynes R. O., Ulcerative colitis and autoimmunity induced by loss of myeloid  v integrins, 10.1073/pnas.0707421104
  13. Sakaguchi Shimon, Miyara Makoto, Costantino Cristina M., Hafler David A., FOXP3+ regulatory T cells in the human immune system, 10.1038/nri2785
  14. Worthington John J., Czajkowska Beata I., Melton Andrew C., Travis Mark A., Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8, 10.1053/j.gastro.2011.06.057
  15. Païdassi Helena, Acharya Mridu, Zhang Ailiang, Mukhopadhyay Subhankar, Kwon Manjae, Chow Camille, Stuart Lynda M., Savill John, Lacy–Hulbert Adam, Preferential Expression of Integrin αvβ8 Promotes Generation of Regulatory T Cells by Mouse CD103+ Dendritic Cells, 10.1053/j.gastro.2011.06.076
  16. Melton Andrew C., Bailey-Bucktrout Samantha L., Travis Mark A., Fife Brian T., Bluestone Jeffrey A., Sheppard Dean, Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice, 10.1172/jci43786
  17. Acharya Mridu, Mukhopadhyay Subhankar, Païdassi Helena, Jamil Tahseen, Chow Camille, Kissler Stephan, Stuart Lynda M., Hynes Richard O., Lacy-Hulbert Adam, αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice, 10.1172/jci43796
  18. Hirota S., Liu Q., Lee H. S., Hossain M. G., Lacy-Hulbert A., McCarty J. H., The astrocyte-expressed integrin  v 8 governs blood vessel sprouting in the developing retina, 10.1242/dev.069153
  19. Arnold T. D., Ferrero G. M., Qiu H., Phan I. T., Akhurst R. J., Huang E. J., Reichardt L. F., Defective Retinal Vascular Endothelial Cell Development As a Consequence of Impaired Integrin  V 8-Mediated Activation of Transforming Growth Factor- , 10.1523/jneurosci.5648-11.2012
  20. Kitamura Hideya, Cambier Stephanie, Somanath Sangeeta, Barker Tyren, Minagawa Shunsuke, Markovics Jennifer, Goodsell Amanda, Publicover Jean, Reichardt Louis, Jablons David, Wolters Paul, Hill Arthur, Marks James D., Lou Jianlong, Pittet Jean-Francois, Gauldie Jack, Baron Jody Lynn, Nishimura Stephen L., Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β, 10.1172/jci45589
  21. Minagawa S., Lou J., Seed R. I., Cormier A., Wu S., Cheng Y., Murray L., Tsui P., Connor J., Herbst R., Govaerts C., Barker T., Cambier S., Yanagisawa H., Goodsell A., Hashimoto M., Brand O. J., Cheng R., Ma R., McKnelly K. J., Wen W., Hill A., Jablons D., Wolters P., Kitamura H., Araya J., Barczak A. J., Erle D. J., Reichardt L. F., Marks J. D., Baron J. L., Nishimura S. L., Selective Targeting of TGF-  Activation to Treat Fibroinflammatory Airway Disease, 10.1126/scitranslmed.3008074
  22. Worthington John J., Kelly Aoife, Smedley Catherine, Bauché David, Campbell Simon, Marie Julien C., Travis Mark A., Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation, 10.1016/j.immuni.2015.04.012
  23. Chaudhry Ashutosh, Rudensky Alexander Y., Control of inflammation by integration of environmental cues by regulatory T cells, 10.1172/jci57175
  24. Edwards Justin P., Thornton Angela M., Shevach Ethan M., Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8, 10.4049/jimmunol.1401102
  25. Mu Dezhi, Cambier Stephanie, Fjellbirkeland Lars, Baron Jody L., Munger John S., Kawakatsu Hisaaki, Sheppard Dean, Broaddus V. Courtney, Nishimura Stephen L., The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1, 10.1083/jcb.200109100
  26. Stockis Julie, Fink Wolfram, François Violaine, Connerotte Thierry, de Smet Charles, Knoops Laurent, van der Bruggen Pierre, Boon Thierry, Coulie Pierre G., Lucas Sophie, Comparison of stable human Treg and Th clones by transcriptional profiling : Molecular immunology, 10.1002/eji.200838807
  27. Shultz Leonard D., Brehm Michael A., Garcia-Martinez J. Victor, Greiner Dale L., Humanized mice for immune system investigation: progress, promise and challenges, 10.1038/nri3311
  28. Hannon, Transfusion, 54, 353 (2014)
  29. Dong Xianchi, Hudson Nathan E, Lu Chafen, Springer Timothy A, Structural determinants of integrin β-subunit specificity for latent TGF-β, 10.1038/nsmb.2905
  30. Annes Justin P., Chen Yan, Munger John S., Rifkin Daniel B., Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1, 10.1083/jcb.200312172
  31. Buscemi Lara, Ramonet David, Klingberg Franco, Formey Aurélie, Smith-Clerc Josiane, Meister Jean-Jacques, Hinz Boris, The Single-Molecule Mechanics of the Latent TGF-β1 Complex, 10.1016/j.cub.2011.11.037
  32. Shi Minlong, Zhu Jianghai, Wang Rui, Chen Xing, Mi Lizhi, Walz Thomas, Springer Timothy A., Latent TGF-β structure and activation, 10.1038/nature10152
  33. Lakhe-Reddy Sujata, Khan Shenaz, Konieczkowski Martha, Jarad George, Wu Karen L., Reichardt Louis F., Takai Yoshimi, Bruggeman Leslie A., Wang Bingcheng, Sedor John R., Schelling Jeffrey R., β8 Integrin Binds Rho GDP Dissociation Inhibitor-1 and Activates Rac1 to Inhibit Mesangial Cell Myofibroblast Differentiation, 10.1074/jbc.m601110200
  34. Reyes S. B., Narayanan A. S., Lee H. S., Tchaicha J. H., Aldape K. D., Lang F. F., Tolias K. F., McCarty J. H.,  v 8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion, 10.1091/mbc.e12-07-0521
  35. Cuende J., Lienart S., Dedobbeleer O., van der Woning B., De Boeck G., Stockis J., Huygens C., Colau D., Somja J., Delvenne P., Hannon M., Baron F., Dumoutier L., Renauld J.-C., De Haard H., Saunders M., Coulie P. G., Lucas S., Monoclonal antibodies against GARP/TGF- 1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo, 10.1126/scitranslmed.aaa1983
  36. Cheerathodi M., Avci N. G., Guerrero P. A., Tang L. K., Popp J., Morales J. E., Chen Z., Carnero A., Lang F. F., Ballif B. A., Rivera G. M., McCarty J. H., The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma, 10.1158/1541-7786.mcr-16-0251
  37. McCarty J. H., Cook A. A., Hynes R. O., An interaction between  v 8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain, 10.1073/pnas.0506068102
  38. Lee Hye Shin, Cheerathodi Mujeeburahiman, Chaki Sankar P., Reyes Steve B., Zheng Yanhua, Lu Zhimin, Paidassi Helena, DerMardirossian Celine, Lacy-Hulbert Adam, Rivera Gonzalo M., McCarty Joseph H., Protein Tyrosine Phosphatase-PEST and β8 Integrin Regulate Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells, 10.1128/mcb.00112-15
  39. Li Yan, Kim Byung-Gyu, Qian Shiguang, Letterio John J., Fung John J., Lu Lina, Lin Feng, Hepatic Stellate Cells Inhibit T Cells through Active TGF-β1 from a Cell Surface–Bound Latent TGF-β1/GARP Complex, 10.4049/jimmunol.1500139
  40. O'Connor Marie N., Salles Isabelle I., Cvejic Ana, Watkins Nicholas A., Walker Adam, Garner Stephen F., Jones Chris I., Macaulay Iain C., Steward Michael, Zwaginga Jaap-Jan, Bray Sarah L., Dudbridge Frank, de Bono Bernard, Goodall Alison H., Deckmyn Hans, Stemple Derek L., Ouwehand Willem H., Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins, 10.1182/blood-2008-06-162693
  41. Carrillo-Galvez Ana Belén, Cobo Marién, Cuevas-Ocaña Sara, Gutiérrez-Guerrero Alejandra, Sánchez-Gilabert Almudena, Bongarzone Pierpaolo, García-Pérez Angélica, Muñoz Pilar, Benabdellah Karim, Toscano Miguel G., Martín Francisco, Anderson Per, Mesenchymal Stromal Cells Express GARP/LRRC32 on Their Surface: Effects on Their Biology and Immunomodulatory Capacity : Role of GARP in MSC Biology and Immunomodulation, 10.1002/stem.1821
  42. Carambia Antonella, Freund Barbara, Schwinge Dorothee, Heine Markus, Laschtowitz Alena, Huber Samuel, Wraith David C., Korn Thomas, Schramm Christoph, Lohse Ansgar W., Heeren Joerg, Herkel Johannes, TGF-β-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells, 10.1016/j.jhep.2014.04.027
  43. Dedobbeleer Olivier, Stockis Julie, van der Woning Bas, Coulie Pierre G., Lucas Sophie, Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA, 10.4049/jimmunol.1601882
  44. Fenton T M, Kelly A, Shuttleworth E E, Smedley C, Atakilit A, Powrie F, Campbell S, Nishimura S L, Sheppard D, Levison S, Worthington J J, Lehtinen M J, Travis M A, Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8, 10.1038/mi.2016.94
  45. Massagué Joan, TGFβ signalling in context, 10.1038/nrm3434
  46. Reboldi A., Arnon T. I., Rodda L. B., Atakilit A., Sheppard D., Cyster J. G., IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches, 10.1126/science.aaf4822
  47. Gauthy Emilie, Cuende Julia, Stockis Julie, Huygens Caroline, Lethé Bernard, Collet Jean-François, Bommer Guido, Coulie Pierre G., Lucas Sophie, GARP Is Regulated by miRNAs and Controls Latent TGF-β1 Production by Human Regulatory T Cells, 10.1371/journal.pone.0076186
  48. Stockis Julie, Colau Didier, Coulie Pierre G., Lucas Sophie, Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg : Cellular immune response, 10.1002/eji.200939684
  49. Tran D. Q., Andersson J., Wang R., Ramsey H., Unutmaz D., Shevach E. M., GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells, 10.1073/pnas.0901944106
  50. Wang R., Zhu J., Dong X., Shi M., Lu C., Springer T. A., GARP regulates the bioavailability and activation of TGF , 10.1091/mbc.e11-12-1018