Lambert, Philippe
[UCL]
Bremhorst, Vincent
[UCL]
The promotion time cure model is a survival model acknowledging that an unidentified proportion of subjects will never experience the event of interest whatever the duration of the follow-up. We focus our interest on the challenges raised by the strong posterior correlation between some of the regression pa- rameters when the same covariates enter the probability to be cured and the time-to-event model for susceptible subjects. Then, the regression parame- ters of shared covariates are correlated with, in addition, identification issues when the follow-up is insufficiently long. We investigate how, despite this, plausible values for these parameters can be obtained in a computationally efficient way. The theoretical properties of our strategy will be investigated by simulation and illustrated on clinical data. Practical recommendations will also be made for the analysis of survival data known to include an unidentified cured fraction.
Bibliographic reference |
Lambert, Philippe ; Bremhorst, Vincent. Estimation and identication issues in the promotion time cure model when the same covariates enter the cure probability and time-to-event model components. ISBA Discussion Paper ; 2017/26 (2017) 20 pages |
Permanent URL |
http://hdl.handle.net/2078.1/189388 |