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Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo.

Bibliographic reference Lambrecht, Caroline ; Libbrecht, Louis ; Sagaert, Xavier ; Pauwels, Patrick ; Hoorne, Yana ; et. al. Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo.. In: Oncogene, , p. [1-9] (2017)
Permanent URL http://hdl.handle.net/2078.1/187977
  1. Janssens Veerle, Goris Jozef, Van Hoof Christine, PP2A: the expected tumor suppressor, 10.1016/j.gde.2004.12.004
  2. Weinberg Robert A., Hahn William C., Counter Christopher M., Lundberg Ante S., Beijersbergen Roderick L., Brooks Mary W., 10.1038/22780
  3. Hahn W. C., Dessain S. K., Brooks M. W., King J. E., Elenbaas B., Sabatini D. M., DeCaprio J. A., Weinberg R. A., Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation, 10.1128/mcb.22.7.2111-2123.2002
  4. Chen Wen, Possemato Richard, Campbell K.Thirza, Plattner Courtney A, Pallas David C, Hahn William C, Identification of specific PP2A complexes involved in human cell transformation, 10.1016/s1535-6108(04)00026-1
  5. Sablina A. A., Hector M., Colpaert N., Hahn W. C., Identification of PP2A Complexes and Pathways Involved in Cell Transformation, 10.1158/0008-5472.can-10-2855
  6. Chen Wen, Arroyo Jason D., Timmons Jamie C., Possemato Richard, Hahn William C., Cancer-Associated PP2A Aα Subunits Induce Functional Haploinsufficiency and Tumorigenicity, 10.1158/0008-5472.can-05-1103
  7. Jackson Jennifer B., Pallas David C., Circumventing Cellular Control of PP2A by Methylation Promotes Transformation in an Akt-Dependent Manner, 10.1593/neo.12768
  8. Yeh Elizabeth, Cunningham Melissa, Arnold Hugh, Chasse Dawn, Monteith Teresa, Ivaldi Giovanni, Hahn William C., Stukenberg P. Todd, Shenolikar Shirish, Uchida Takafumi, Counter Christopher M., Nevins Joseph R., Means Anthony R., Sears Rosalie, A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells, 10.1038/ncb1110
  9. Sablina Anna A., Chen Wen, Arroyo Jason D., Corral Laura, Hector Melissa, Bulmer Sara E., DeCaprio James A., Hahn William C., The Tumor Suppressor PP2A Aβ Regulates the RalA GTPase, 10.1016/j.cell.2007.03.047
  10. Miller Jeffrey P., Yeh Nancy, Hofstetter Christoph P., Keskin Doruk, Goldstein Andrew S., Koff Andrew, p27kip1Protein Levels Reflect a Nexus of Oncogenic Signaling during Cell Transformation, 10.1074/jbc.m112.361972
  11. Perrotti Danilo, Neviani Paolo, Protein phosphatase 2A: a target for anticancer therapy, 10.1016/s1470-2045(12)70558-2
  12. Sangodkar Jaya, Farrington Caroline C., McClinch Kimberly, Galsky Matthew D., Kastrinsky David B., Narla Goutham, All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase, 10.1111/febs.13573
  13. Wang S. S., Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer, 10.1126/science.282.5387.284
  14. Calin George A, di Iasio Maria Grazia, Caprini Elisabetta, Vorechovsky Igor, Natali Pier Giorgio, Sozzi Gabriella, Croce Carlo M, Barbanti-Brodano Giuseppe, Russo Giandomenico, Negrini Massimo, Low frequency of alterations of the α (PPP2R1A) and β (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms, 10.1038/sj.onc.1203389
  15. Shih Ie-Ming, Wang Tian-Li, Mutation of PPP2R1A: a new clue in unveiling the pathogenesis of uterine serous carcinoma, 10.1002/path.2884
  16. Haesen Dorien, Abbasi Asbagh Layka, Derua Rita, Hubert Antoine, Schrauwen Stefanie, Hoorne Yana, Amant Frédéric, Waelkens Etienne, Sablina Anna, Janssens Veerle, Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth , 10.1158/0008-5472.can-15-3342
  17. Ruediger R., Ruiz J., Walter G., Human Cancer-Associated Mutations in the A  Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A  Knock-In and Knockout Mice, 10.1128/mcb.05744-11
  18. Cheng Yu, Liu Wennuan, Kim Seong-Tae, Sun Jishan, Lu Lingyi, Sun Jielin, Zheng Siqun Lilly, Isaacs William B., Xu Jianfeng, Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study, 10.1016/j.cancergen.2011.05.002
  19. Nobumori Y., Shouse G. P., Wu Y., Lee K. J., Shen B., Liu X., B56  Tumor-Associated Mutations Provide New Mechanisms for B56 -PP2A Tumor Suppressor Activity, 10.1158/1541-7786.mcr-12-0633
  20. Curtis C, Nature, 486, 346 (2012)
  21. Bluemn E. G., Spencer E. S., Mecham B., Gordon R. R., Coleman I., Lewinshtein D., Mostaghel E., Zhang X., Annis J., Grandori C., Porter C., Nelson P. S., PPP2R2C Loss Promotes Castration-Resistance and Is Associated with Increased Prostate Cancer-Specific Mortality, 10.1158/1541-7786.mcr-12-0710
  22. Cristobal I., Cirauqui C., Castello-Cros R., Garcia-Orti L., Calasanz M. J., Odero M. D., Downregulation of PPP2R5E is a common event in acute myeloid leukemia that affects the oncogenic potential of leukemic cells, 10.3324/haematol.2013.084731
  23. Arriazu Elena, Pippa Raffaella, Odero María D., Protein Phosphatase 2A as a Therapeutic Target in Acute Myeloid Leukemia, 10.3389/fonc.2016.00078
  24. Khanna A., Pimanda J. E., Westermarck J., Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging Human Oncoprotein and a Potential Cancer Therapy Target, 10.1158/0008-5472.can-13-1994
  25. Chen L-P, Lai Y-D, Li D-C, Zhu X-N, Yang P, Li W-X, Zhu W, Zhao J, Li X-D, Xiao Y-M, Zhang Y, Xing X-M, Wang Q, Zhang B, Lin Y-C, Zeng J-L, Zhang S-X, Liu C-X, Li Z-F, Zeng X-W, Lin Z-N, Zhuang Z-X, Chen W, α4 is highly expressed in carcinogen-transformed human cells and primary human cancers, 10.1038/onc.2011.20
  26. Puustinen P., Junttila M. R., Vanhatupa S., Sablina A. A., Hector M. E., Teittinen K., Raheem O., Ketola K., Lin S., Kast J., Haapasalo H., Hahn W. C., Westermarck J., PME-1 Protects Extracellular Signal-Regulated Kinase Pathway Activity from Protein Phosphatase 2A-Mediated Inactivation in Human Malignant Glioma, 10.1158/0008-5472.can-08-2760
  27. Wandzioch E., Pusey M., Werda A., Bail S., Bhaskar A., Nestor M., Yang J.-J., Rice L. M., PME-1 Modulates Protein Phosphatase 2A Activity to Promote the Malignant Phenotype of Endometrial Cancer Cells, 10.1158/0008-5472.can-13-3130
  28. Olive Kenneth P., Tuveson David A., Ruhe Zachary C., Yin Bob, Willis Nicholas A., Bronson Roderick T., Crowley Denise, Jacks Tyler, Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome, 10.1016/j.cell.2004.11.004
  29. Lang Gene A., Iwakuma Tomoo, Suh Young-Ah, Liu Geng, Rao V.Ashutosh, Parant John M., Valentin-Vega Yasmine A., Terzian Tamara, Caldwell Lisa C., Strong Louise C., El-Naggar Adel K., Lozano Guillermina, Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome, 10.1016/j.cell.2004.11.006
  30. Hu N, Oncogene, 9, 1021 (1994)
  31. Louis J. V., Martens E., Borghgraef P., Lambrecht C., Sents W., Longin S., Zwaenepoel K., Pijnenborg R., Landrieu I., Lippens G., Ledermann B., Gotz J., Van Leuven F., Goris J., Janssens V., Mice lacking phosphatase PP2A subunit PR61/B'  (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3 , 10.1073/pnas.1018777108
  32. Ward Jerrold M., Lymphomas and leukemias in mice, 10.1016/j.etp.2006.01.007
  33. Singal Amit G., El-Serag Hashem B., Hepatocellular Carcinoma From Epidemiology to Prevention: Translating Knowledge into Practice, 10.1016/j.cgh.2015.08.014
  34. Seeling J. M., Regulation of -Catenin Signaling by the B56 Subunit of Protein Phosphatase 2A, 10.1126/science.283.5410.2089
  35. Letourneux Claire, Rocher Géraldine, Porteu Françoise, B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK, 10.1038/sj.emboj.7600980
  36. Hahn Katrin, Miranda Merce, Francis Víctor A., Vendrell Joan, Zorzano Antonio, Teleman Aurelio A., PP2A Regulatory Subunit PP2A-B′ Counteracts S6K Phosphorylation, 10.1016/j.cmet.2010.03.015
  37. Pinyol Roser, Nault Jean, Quetglas Iris, Zucman-Rossi Jessica, Llovet Josep, Molecular Profiling of Liver Tumors: Classification and Clinical Translation for Decision Making, 10.1055/s-0034-1394137
  38. Cadoret Axelle, Ovejero Christine, Terris Benoit, Souil Evelyne, Lévy Laurence, Lamers Wouter H, Kitajewski Jan, Kahn Axel, Perret Christine, New targets of β-catenin signaling in the liver are involved in the glutamine metabolism, 10.1038/sj.onc.1206118
  39. Janky Rekin's, Verfaillie Annelien, Imrichová Hana, Van de Sande Bram, Standaert Laura, Christiaens Valerie, Hulselmans Gert, Herten Koen, Naval Sanchez Marina, Potier Delphine, Svetlichnyy Dmitry, Kalender Atak Zeynep, Fiers Mark, Marine Jean-Christophe, Aerts Stein, iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections, 10.1371/journal.pcbi.1003731
  40. Hydbring P., Bahram F., Su Y., Tronnersjo S., Hogstrand K., von der Lehr N., Sharifi H. R., Lilischkis R., Hein N., Wu S., Vervoorts J., Henriksson M., Grandien A., Luscher B., Larsson L.-G., Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation, 10.1073/pnas.0900121106
  41. Khanna Anchit, Böckelman Camilla, Hemmes Annabrita, Junttila Melissa R., Wiksten Jan-Patrik, Lundin Mikael, Junnila Siina, Murphy Daniel J., Evan Gerard I., Haglund Caj, Westermarck Jukka, Ristimäki Ari, MYC-Dependent Regulation and Prognostic Role of CIP2A in Gastric Cancer, 10.1093/jnci/djp103
  42. Shachaf Catherine M., Kopelman Andrew M., Arvanitis Constadina, Karlsson Åsa, Beer Shelly, Mandl Stefanie, Bachmann Michael H., Borowsky Alexander D., Ruebner Boris, Cardiff Robert D., Yang Qiwei, Bishop J. Michael, Contag Christopher H., Felsher Dean W., MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer, 10.1038/nature03043
  43. Kaposi-Novak P., Libbrecht L., Woo H. G., Lee Y.-H., Sears N. C., Conner E. A., Factor V. M., Roskams T., Thorgeirsson S. S., Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis, 10.1158/0008-5472.can-08-3357
  44. Liu L., Eisenman R. N., Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3 -Negative Feedback Pathway, 10.1177/1947601912448067
  45. Arnold H. K., Sears R. C., Protein Phosphatase 2A Regulatory Subunit B56  Associates with c-Myc and Negatively Regulates c-Myc Accumulation, 10.1128/mcb.26.7.2832-2844.2006
  46. He T., Identification of c-MYC as a Target of the APC Pathway, 10.1126/science.281.5382.1509
  47. Shouse G P, Nobumori Y, Liu X, A B56γ mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A, 10.1038/onc.2010.161
  48. Lai Tai-Yu, Yen Chia-Jui, Tsai Hung-Wen, Yang Yu-San, Hong Wei-Fu, Chiang Chi-Wu, The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1, 10.18632/oncotarget.6609
  49. Varadkar Prajakta, Despres Daryl, Kraman Matthew, Lozier Julie, Phadke Aditi, Nagaraju Kanneboyina, Mccright Brent, The protein phosphatase 2A B56γ regulatory subunit is required for heart development : PP2A-B56γ is Required for Heart Development, 10.1002/dvdy.24111
  50. Cheng Yong-Sheng, Seibert Oksana, Klöting Nora, Dietrich Arne, Straßburger Katrin, Fernández-Veledo Sonia, Vendrell Joan J., Zorzano Antonio, Blüher Matthias, Herzig Stephan, Berriel Diaz Mauricio, Teleman Aurelio A., PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis, 10.1371/journal.pgen.1005561
  51. Low I. C. C., Loh T., Huang Y., Virshup D. M., Pervaiz S., Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56  stabilizes its antiapoptotic activity, 10.1182/blood-2014-03-563296
  52. Hung M-H, Chen Y-L, Chu P-Y, Shih C-T, Yu H-C, Tai W-T, Shiau C-W, Chen K-F, Upregulation of the oncoprotein SET determines poor clinical outcomes in hepatocellular carcinoma and shows therapeutic potential, 10.1038/onc.2016.21
  53. He Hui, Wu Gang, Li Weijie, Cao Yuecheng, Liu Yongfeng, CIP2A Is Highly Expressed in Hepatocellular Carcinoma and Predicts Poor Prognosis : , 10.1097/pdm.0b013e318249fd8b
  54. Janghorban M., Farrell A. S., Allen-Petersen B. L., Pelz C., Daniel C. J., Oddo J., Langer E. M., Christensen D. J., Sears R. C., Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer, 10.1073/pnas.1317630111
  55. Junttila Melissa R., Puustinen Pietri, Niemelä Minna, Ahola Raija, Arnold Hugh, Böttzauw Trine, Ala-aho Risto, Nielsen Christina, Ivaska Johanna, Taya Yoichi, Lu Shi-Long, Lin Shujun, Chan Edward K.L., Wang Xiao-Jing, Grènman Reidar, Kast Juergen, Kallunki Tuula, Sears Rosalie, Kähäri Veli-Matti, Westermarck Jukka, CIP2A Inhibits PP2A in Human Malignancies, 10.1016/j.cell.2007.04.044
  56. Leder Aya, Pattengale Paul K., Kuo Ann, Stewart Timothy A., Leder Philip, Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development, 10.1016/0092-8674(86)90280-1
  57. Martin Marcel, Cutadapt removes adapter sequences from high-throughput sequencing reads, 10.14806/ej.17.1.200
  58. Trapnell Cole, Pachter Lior, Salzberg Steven L., TopHat: discovering splice junctions with RNA-Seq, 10.1093/bioinformatics/btp120
  59. Li H., Handsaker B., Wysoker A., Fennell T., Ruan J., Homer N., Marth G., Abecasis G., Durbin R., , The Sequence Alignment/Map format and SAMtools, 10.1093/bioinformatics/btp352
  60. Trapnell Cole, Williams Brian A, Pertea Geo, Mortazavi Ali, Kwan Gordon, van Baren Marijke J, Salzberg Steven L, Wold Barbara J, Pachter Lior, Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation, 10.1038/nbt.1621
  61. Quinlan Aaron R., Hall Ira M., BEDTools: a flexible suite of utilities for comparing genomic features, 10.1093/bioinformatics/btq033
  62. Robinson M. D., McCarthy D. J., Smyth G. K., edgeR: a Bioconductor package for differential expression analysis of digital gene expression data, 10.1093/bioinformatics/btp616
  63. Martens Ellen, Stevens Ilse, Janssens Veerle, Vermeesch Joris, Götz Jürgen, Goris Jozef, Van Hoof Christine, Genomic Organisation, Chromosomal Localisation Tissue Distribution and Developmental Regulation of the PR61/B′ Regulatory Subunits of Protein Phosphatase 2A in Mice, 10.1016/j.jmb.2003.12.047