User menu

Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies

Bibliographic reference Furtado, N ; Pirson, L ; Edelberg, Hélène ; Miranda, L ; Loira Pastoriza, Cristina ; et. al. Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies. In: Molecules (Print Archive Edition), Vol. 22, no.400 (march 2017)
Permanent URL http://hdl.handle.net/2078.1/183347
  1. Muffler Kai, Leipold Doris, Scheller Marie-Christin, Haas Christiane, Steingroewer Juliane, Bley Thomas, Neuhaus H. Ekkehard, Mirata Marco Antonio, Schrader Jens, Ulber Roland, Biotransformation of triterpenes, 10.1016/j.procbio.2010.07.015
  2. Sheng Huaming, Sun Hongbin, Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases, 10.1039/c0np00059k
  3. Siddique Hifzur Rahman, Saleem Mohammad, Beneficial health effects of lupeol triterpene: A review of preclinical studies, 10.1016/j.lfs.2010.11.020
  4. Moreau Robert A., Whitaker Bruce D., Hicks Kevin B., Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses, 10.1016/s0163-7827(02)00006-1
  5. Szakiel Anna, Pączkowski Cezary, Pensec Flora, Bertsch Christophe, Fruit cuticular waxes as a source of biologically active triterpenoids, 10.1007/s11101-012-9241-9
  6. Pádua Tatiana A., de Abreu Bianca S. S. C., Costa Thadeu E. M. M., Nakamura Marcos J., Valente Lígia M. M., Henriques Maria das Graças, Siani Antonio C., Rosas Elaine C., Anti-inflammatory effects of methyl ursolate obtained from a chemically derived crude extract of apple peels: potential use in rheumatoid arthritis, 10.1007/s12272-014-0345-1
  7. Smina T.P., Mathew J., Janardhanan K.K., Devasagayam T.P.A., Antioxidant activity and toxicity profile of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst occurring in South India, 10.1016/j.etap.2011.08.011
  8. Cichewicz Robert H., Kouzi Samir A., Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection, 10.1002/med.10053
  9. Alqahtani A., Hamid K., Kam A., Wong K.H., Abdelhak Z., Razmovski-Naumovski V., Chan K., Li K.M., Groundwater P.W., Li G.Q., The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications, 10.2174/0929867311320070007
  10. Laszczyk Melanie, Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy, 10.1055/s-0029-1186102
  11. Prasad Sahdeo, Kalra Neetu, Shukla Yogeshwer, Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice, 10.1002/mnfr.200600113
  12. Hussain Shaik Althaf, Rasool S.N., Kareem M. Abdul, Krushna G. Saayi, Akhtar P. Mohammad, Devi Kodidhela Lakshmi, Maslinic Acid Protects Against Isoproterenol-Induced Cardiotoxicity in Albino Wistar Rats, 10.1089/jmf.2012.2191
  13. Rodriguez-Rodriguez Rosalia, Oleanolic Acid and Related Triterpenoids from Olives on Vascular Function: Molecular Mechanisms and Therapeutic Perspectives, 10.2174/0929867322666141212122921
  14. M.R. Patlolla Jagan, V. Rao Chinthalapally, Triterpenoids for Cancer Prevention and Treatment: Current Status and Future Prospects, 10.2174/138920112798868719
  15. Sánchez Marianela, Theoduloz Cristina, Schmeda-Hirschmann Guillermo, Razmilic Iván, Yáñez Tania, Rodríguez Jaime A., Gastroprotective and ulcer-healing activity of oleanolic acid derivatives: In vitro–in vivo relationships, 10.1016/j.lfs.2006.03.044
  16. Tausch L., Henkel A., Siemoneit U., Poeckel D., Kather N., Franke L., Hofmann B., Schneider G., Angioni C., Geisslinger G., Skarke C., Holtmeier W., Beckhaus T., Karas M., Jauch J., Werz O., Identification of Human Cathepsin G As a Functional Target of Boswellic Acids from the Anti-Inflammatory Remedy Frankincense, 10.4049/jimmunol.0803574
  17. Skarke Carsten, Kuczka Karina, Tausch Lars, Werz Oliver, Rossmanith Tanja, Barrett Jeffrey S., Harder Sebastian, Holtmeier Wolfgang, Schwarz Joachim A., Increased Bioavailability of 11-Keto-β-Boswellic Acid Following Single Oral Dose Frankincense Extract Administration After a Standardized Meal in Healthy Male Volunteers: Modeling and Simulation Considerations for Evaluating Drug Exposures, 10.1177/0091270011422811
  18. Sterk Vanessa, Büchele Berthold, Simmet Thomas, Effect of Food Intake on the Bioavailability of Boswellic Acids from a Herbal Preparation in Healthy Volunteers, 10.1055/s-2004-835844
  19. Sharma S., Thawani V., Hingorani L., Shrivastava M., Bhate V.R., Khiyani R., Pharmacokinetic study of 11-Keto β-Boswellic Acid, 10.1078/0944-7113-00290
  20. Kaeidi Ayat, Esmaeili-Mahani Saeed, Sheibani Vahid, Abbasnejad Mehdi, Rasoulian Bahram, Hajializadeh Zahra, Afrazi Samira, Olive (Olea europaea L.) leaf extract attenuates early diabetic neuropathic pain through prevention of high glucose-induced apoptosis: In vitro and in vivo studies, 10.1016/j.jep.2011.04.038
  21. Wang Xin, Li Yu-Liang, Wu Hao, Liu Jiang-Zheng, Hu Jun-Xia, Liao Nai, Peng Jie, Cao Pei-Pei, Liang Xin, Hai Chun-Xu, Antidiabetic Effect of Oleanolic Acid: A Promising Use of a Traditional Pharmacological Agent : PROMISING USE OF OA IN THE TREATMENT OF DM, 10.1002/ptr.3385
  22. Hu, 568 (2011)
  23. Dewick, 546 (2009)
  24. Jäger Sebastian, Trojan Holger, Kopp Thomas, Laszczyk Melanie N., Scheffler Armin, Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts, 10.3390/molecules14062016
  25. Andre Christelle M., Legay Sylvain, Deleruelle Amélie, Nieuwenhuizen Niels, Punter Matthew, Brendolise Cyril, Cooney Janine M., Lateur Marc, Hausman Jean-François, Larondelle Yvan, Laing William A., Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids, 10.1111/nph.13996
  26. Andre Christelle M., Larsen Lesley, Burgess Elaine J., Jensen Dwayne J., Cooney Janine M., Evers Danièle, Zhang Jingli, Perry Nigel B., Laing William A., Unusual Immuno-Modulatory Triterpene-Caffeates in the Skins of Russeted Varieties of Apples and Pears, 10.1021/jf305190e
  27. Morrissey, 283 (2009)
  28. Netala, Int. J. Pharm. Pharm. Sci., 7, 24 (2015)
  29. Andre Christelle M., Greenwood Jeffrey M., Walker Edward G., Rassam Maysoon, Sullivan Michael, Evers Danièle, Perry Nigel B., Laing William A., Anti-Inflammatory Procyanidins and Triterpenes in 109 Apple Varieties, 10.1021/jf302809k
  30. Yamaguchi Hideaki, Noshita Toshiro, Kidachi Yumi, Umetsu Hironori, Hayashi Masahiko, Komiyama Kanki, Funayama Shinji, Ryoyama Kazuo, Isolation of Ursolic Acid from Apple Peels and Its Specific Efficacy as a Potent Antitumor Agent, 10.1248/jhs.54.654
  31. Wang Wei-Hsun, Chuang Hui-Yen, Chen Chien-Hui, Chen Wun-Ke, Hwang Jeng-Jong, Lupeol acetate ameliorates collagen-induced arthritis and osteoclastogenesis of mice through improvement of microenvironment, 10.1016/j.biopha.2016.02.010
  32. Yin Mei-Chin, Lin Ming-Cheng, Mong Mei-Chin, Lin Chia-Yu, Bioavailability, Distribution, and Antioxidative Effects of Selected Triterpenes in Mice, 10.1021/jf302529x
  33. Juan M. Emília, Planas Joana M., Ruiz-Gutierrez Valentina, Daniel Hannelore, Wenzel Uwe, Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells, 10.1017/s0007114508882979
  34. Siddiqui Bina Shaheen, Aslam Huma, Ali Syed Tariq, Begum Sabira, Khatoon Nasima, Two New Triterpenoids and a Steroidal Glycoside from the Aerial Parts of Ocimum basilicum, 10.1248/cpb.55.516
  35. Razboršek Maša Islamčević, Vončina Darinka Brodnjak, Doleček Valter, Vončina Ernest, Determination of Oleanolic, Betulinic and Ursolic Acid in Lamiaceae and Mass Spectral Fragmentation of Their Trimethylsilylated Derivatives, 10.1365/s10337-008-0533-6
  36. Ovesná, Neoplasma, 51, 327 (2004)
  37. Raval Nisith, Mistry Tejas, Acharya Niyati, Acharya Sanjeev, Development of glutathione-conjugated asiatic acid-loaded bovine serum albumin nanoparticles for brain-targeted drug delivery : Bovine serum albumin nanoparticles, 10.1111/jphp.12460
  38. Judy William V., Hari Siva P., Stogsdill W.W., Judy Janet S., Naguib Yousry M.A., Passwater Richard, Antidiabetic activity of a standardized extract (Glucosol™) from Lagerstroemia speciosa leaves in Type II diabetics, 10.1016/s0378-8741(03)00122-3
  39. Ganbold Munkhchimeg, Barker James, Ma Ren, Jones Lucy, Carew Mark, Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC, 10.1016/j.jep.2010.07.014
  40. Joos Stefanie, Rosemann Thomas, Szecsenyi Joachim, Hahn Eckhart G, Willich Stefan N, Brinkhaus Benno, Use of complementary and alternative medicine in Germany – a survey of patients with inflammatory bowel disease, 10.1186/1472-6882-6-19
  41. Liu Jie, Oleanolic acid and ursolic acid: Research perspectives, 10.1016/j.jep.2005.05.024
  42. SANCHEZAVILA N, PRIEGOCAPOTE F, RUIZJIMENEZ J, LUQUEDECASTRO M, Fast and selective determination of triterpenic compounds in olive leaves by liquid chromatography–tandem mass spectrometry with multiple reaction monitoring after microwave-assisted extraction, 10.1016/j.talanta.2008.10.037
  43. Romero Concepción, García Aranzazu, Medina Eduardo, Ruíz-Méndez Mª Victoria, Castro Antonio de, Brenes Manuel, Triterpenic acids in table olives, 10.1016/j.foodchem.2009.05.037
  44. Pérez-Camino M. C., Cert A., Quantitative Determination of Hydroxy Pentacyclic Triterpene Acids in Vegetable Oils, 10.1021/jf980881h
  45. Dale, 829 (2007)
  46. Heaney, J. Nutr., 131, 1344S (2001)
  47. Rein Maarit J., Renouf Mathieu, Cruz-Hernandez Cristina, Actis-Goretta Lucas, Thakkar Sagar K., da Silva Pinto Marcia, Bioavailability of bioactive food compounds: a challenging journey to bioefficacy : Bioavailability of bioactive food compounds, 10.1111/j.1365-2125.2012.04425.x
  48. van Willige Remco W?G, Linssen Jozef P?H, Voragen Alphons G?J, Influence of food matrix on absorption of flavour compounds by linear low-density polyethylene: proteins and carbohydrates, 10.1002/1097-0010(20000915)80:12<1779::aid-jsfa726>3.0.co;2-f
  49. Riedl, J. Nutr., 129, 2170 (1999)
  50. Artursson Per, Palm Katrin, Luthman Kristina, Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1, 10.1016/s0169-409x(00)00128-9
  51. Martin Yvonne C., A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry, 10.1021/jm00135a001
  52. Buckley Stephen T., Fischer Sarah M., Fricker Gert, Brandl Martin, In vitro models to evaluate the permeability of poorly soluble drug entities: Challenges and perspectives, 10.1016/j.ejps.2011.12.007
  53. Bérangère Claude, Caussarieu Nathalie, Morin Philippe, Morin-Allory Luc, Lafosse Michel, Rapid analysis of triterpenic acids by liquid chromatography using porous graphitic carbon and evaporative light scattering detection, 10.1002/jssc.200401764
  54. Rafat Marjan, Fong Kit Wah, Goldsipe Arthur, Stephenson Brian C., Coradetti Samuel T., Sambandan T.G., Sinskey Anthony J., Rha ChoKyun, Association (micellization) and partitioning of aglycon triterpenoids, 10.1016/j.jcis.2008.05.046
  55. Lipinski Christopher A., Drug-like properties and the causes of poor solubility and poor permeability, 10.1016/s1056-8719(00)00107-6
  56. Gareth, 621 (2007)
  57. Benet Leslie Z., Hosey Chelsea M., Ursu Oleg, Oprea Tudor I., BDDCS, the Rule of 5 and drugability, 10.1016/j.addr.2016.05.007
  58. Xu Changjiang, Li Christina Yong-Tao, Kong Ah-Ng Tony, Induction of phase I, II and III drug metabolism/transport by xenobiotics, 10.1007/bf02977789
  59. Yang Yoon Mee, Noh Kyoung, Han Chang Yeob, Kim Sang Geon, Transactivation of Genes Encoding for Phase II Enzymes and Phase III Transporters by Phytochemical Antioxidants, 10.3390/molecules15096332
  60. Berger Valérie, Gabriel Anne-Françoise, Sergent Thérèse, Trouet André, Larondelle Yvan, Schneider Yves-Jacques, Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2), 10.1016/s0378-4274(03)00043-2
  61. Cháirez-Ramírez M.H., Sánchez-Burgos J.A., Gomes C., Moreno-Jiménez M.R., González-Laredo R.F., Bernad-Bernad M.J., Medina-Torres L., Ramírez-Mares M.V., Gallegos-Infante J.A., Rocha-Guzmán N.E., Morphological and release characterization of nanoparticles formulated with poly (dl-lactide-co-glycolide) (PLGA) and lupeol: In vitro permeability and modulator effect on NF-κB in Caco-2 cell system stimulated with TNF-α, 10.1016/j.fct.2015.08.003
  62. Yee Shiyin, 10.1023/a:1012102522787
  63. Rajendran Praveen, Jaggi Manu, Singh Manoj K., Mukherjee Rama, Burman Anand C., Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity, 10.1007/s10637-007-9081-4
  64. Jeong Dong Won, Kim Young Hoon, Kim Hui Hyun, Ji Hye Young, Yoo Sun Dong, Choi Won Rack, Lee Soo Min, Han Chang-Kyun, Lee Hye Suk, Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats, 10.1002/bdd.530
  65. Tong Henry H.Y., Du Zhen, Wang Geng Nan, Chan H.M., Chang Qi, Lai Leon C.M., Chow Albert H.L., Zheng Y., Spray freeze drying with polyvinylpyrrolidone and sodium caprate for improved dissolution and oral bioavailability of oleanolic acid, a BCS Class IV compound, 10.1016/j.ijpharm.2010.11.027
  66. Srinivasan Balaji, Kolli Aditya Reddy, Esch Mandy Brigitte, Abaci Hasan Erbil, Shuler Michael L., Hickman James J., TEER Measurement Techniques for In Vitro Barrier Model Systems, 10.1177/2211068214561025
  67. Cao Feng, Gao Yahan, Wang Meng, Fang Lei, Ping Qineng, Propylene Glycol-Linked Amino Acid/Dipeptide Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability, and Pharmacokinetics, 10.1021/mp300647m
  68. Qiang Zhiyi, Ye Zhong, Hauck Cathy, Murphy Patricia A., McCoy Joe-Ann, Widrlechner Mark P., Reddy Manju B., Hendrich Suzanne, Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers, 10.1016/j.jep.2011.07.037
  69. Yuan Yongfang, Zhang Hai, Sun Fengfeng, Sun Sen, Zhu Zhenyu, Chai Yifeng, Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC–MS method, 10.1016/j.jep.2015.01.006
  70. Krüger Phillip, Kanzer Johanna, Hummel Jessica, Fricker Gert, Schubert-Zsilavecz Manfred, Abdel-Tawab Mona, Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2, 10.1016/j.ejps.2008.10.005
  71. Hüsch Jan, Gerbeth Kathleen, Fricker Gert, Setzer Constanze, Zirkel Jürgen, Rebmann Herbert, Schubert-Zsilavecz Manfred, Abdel-Tawab Mona, Effect of Phospholipid-Based Formulations ofBoswellia serrataExtract on the Solubility, Permeability, and Absorption of the Individual Boswellic Acid Constituents Present, 10.1021/np300009w
  72. Gerbeth Kathleen, Hüsch Jan, Fricker Gert, Werz Oliver, Schubert-Zsilavecz Manfred, Abdel-Tawab Mona, In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins, 10.1016/j.fitote.2012.10.009
  73. Udeani George O., Zhao Guo-Min, Geun Shin Young, Cooke Blaire P., Graham James, Beecher Christopher W.W., Kinghorn A. Douglas, Pezzuto John M., Pharmacokinetics and tissue distribution of betulinic acid in CD-1 mice, 10.1002/1099-081x(199911)20:8<379::aid-bdd198>3.0.co;2-c
  74. Godugu Chandraiah, Patel Apurva R., Doddapaneni Ravi, Somagoni Jaganmohan, Singh Mandip, Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid, 10.1371/journal.pone.0089919
  75. Soica Codruta, Danciu Corina, Savoiu-Balint Germaine, Borcan Florin, Ambrus Rita, Zupko Istvan, Bojin Florina, Coricovac Dorina, Ciurlea Sorina, Avram Stefana, Dehelean Cristina, Olariu Teodora, Matusz Petru, Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells, 10.3390/ijms15058235
  76. Sun Yan-Fang, Song Chuan-Kui, Viernstein Helmut, Unger Frank, Liang Zong-Suo, Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway, 10.1016/j.foodchem.2012.10.079
  77. Dehelean Cristina A., Feflea Stefana, Ganta Srinivas, Amiji Mansoor, Anti-Angiogenic Effects of Betulinic Acid Administered in Nanoemulsion Formulation Using Chorioallantoic Membrane Assay, 10.1166/jbn.2011.1297
  78. Yang Min, Wang Guang Ji, Wang Su Jun, Li Xiao Tian, Xu Yu Ping, Wang Song Pei, Xiang Jing De, Pan Shang Ren, Cao Guo Xian, Ye Wen Cai, Quantitative analysis of 23-hydroxybetulinic acid in mouse plasma using electrospray liquid chromatography/mass spectrometry, 10.1002/rcm.1961
  79. Martin David E, Blum Robert, Doto Judy, Galbraith Hal, Ballow Charles, Multiple-Dose Pharmacokinetics and??Safety of Bevirimat, a??Novel??Inhibitor??of??HIV Maturation,??in??Healthy??Volunteers : , 10.2165/00003088-200746070-00004
  80. Li Jizhen, Goto Masuo, Yang Xiaoming, Morris-Natschke Susan L., Huang Li, Chen Chin-Ho, Lee Kuo-Hsiung, Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity, 10.1016/j.bmcl.2015.11.029
  81. Cheng Xun, Shin Young Geun, Levine Barry S., Smith Adaline C., Tomaszewski Joseph E., van Breemen Richard B., Quantitative analysis of betulinic acid in mouse, rat and dog plasma using electrospray liquid chromatography/mass spectrometry, 10.1002/rcm.1155
  82. Cao Feng, Jia Jinghao, Yin Zhi, Gao Yahan, Sha Lei, Lai Yisheng, Ping Qineng, Zhang Yihua, Ethylene Glycol-Linked Amino Acid Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics, 10.1021/mp200447r
  83. Xi Jia, Chang Qi, Chan Chak K., Meng Zhao Yu, Wang Geng Nan, Sun Jia Bei, Wang Yi Tao, Tong Henry H. Y., Zheng Ying, Formulation Development and Bioavailability Evaluation of a Self-Nanoemulsified Drug Delivery System of Oleanolic Acid, 10.1208/s12249-009-9190-9
  84. Jiang Qikun, Yang Xiaoxu, Du Ping, Zhang Huifen, Zhang Tianhong, Dual strategies to improve oral bioavailability of oleanolic acid: Enhancing water-solubility, permeability and inhibiting cytochrome P450 isozymes, 10.1016/j.ejpb.2015.11.013
  85. Yang, Int. J. Nanomed., 8, 2917 (2013)
  86. Li Wenji, Das Surajit, Ng Ka-yun, Heng Paul W. S., Formulation, Biological and Pharmacokinetic Studies of Sucrose Ester-Stabilized Nanosuspensions of Oleanolic Acid, 10.1007/s11095-011-0428-3
  87. Shi Meiyun, Yang Yan, Sun Yantong, Cheng Longmei, Zhao Sen, Xu Huibo, Fawcett J. Paul, Sun Xiaobo, Gu Jingkai, Pharmacokinetic study of calenduloside E and its active metabolite oleanolic acid in beagle dog using liquid chromatography–tandem mass spectrometry, 10.1016/j.jchromb.2014.01.036
  88. Li Yuanyuan, Liu Hongzhuo, Guo Bei, Li Yun, Geng Yajie, Zhao Furong, Zhang Tianhong, Enhancement of dissolution rate and oral bioavailability in beagle dogs of oleanolic acid by adsorbing onto porous silica using supercritical carbon dioxide, 10.1016/s1773-2247(14)50077-9
  89. Kanellos P. T., Kaliora A. C., Gioxari A., Christopoulou G. O., Kalogeropoulos N., Karathanos V. T., Absorption and Bioavailability of Antioxidant Phytochemicals and Increase of Serum Oxidation Resistance in Healthy Subjects Following Supplementation with Raisins, 10.1007/s11130-013-0389-2
  90. Sánchez-González Marta, Colom Helena, Lozano-Mena Glòria, Juan M. Emília, Planas Joana M., Population pharmacokinetics of maslinic acid, a triterpene from olives, after intravenous and oral administration in rats, 10.1002/mnfr.201400147
  91. Zhou Xiao Ju, Hu Xian Ming, Yi Yi Mu, Wan Jing, Preparation and Body Distribution of Freeze-Dried Powder of Ursolic Acid Phospholipid Nanoparticles, 10.1080/03639040802302165
  92. Ge Zhi-Qiang, Du Xin-Ying, Huang Xiao-Nan, Qiao Bin, Enhanced oral bioavailability of ursolic acid nanoparticles via antisolvent precipitation with TPGS1000 as a stabilizer, 10.1016/j.jddst.2015.08.001
  93. Yang Lei, Sun Zhen, Zu Yuangang, Zhao Chunjian, Sun Xiaowei, Zhang Zhonghua, Zhang Lin, Physicochemical properties and oral bioavailability of ursolic acid nanoparticles using supercritical anti-solvent (SAS) process, 10.1016/j.foodchem.2011.10.083
  94. Yang Guang, Yang Tan, Zhang Wendian, Lu Miao, Ma Xiang, Xiang Guangya, In Vitro and in Vivo Antitumor Effects of Folate-Targeted Ursolic Acid Stealth Liposome, 10.1021/jf405675g
  95. Rush W. R., Murray G. R., Graham D. J. M., The comparative steady-state bioavailability of the active ingredients of madecassol, 10.1007/bf03190180
  96. Lingling Gu, Yuan Zhao, Weigen Lu, Preparation, optimization, characterization and in vivo pharmacokinetic study of asiatic acid tromethamine salt-loaded solid lipid nanoparticles, 10.3109/03639045.2015.1135934
  97. Li Jing-jing, Li Yi, Bai Min, Tan Jing-fu, Wang Qiang, Yang Jie, Simultaneous determination of corosolic acid and euscaphic acid in the plasma of normal and diabetic rat after oral administration of extract ofPotentilla discolorBunge by high-performance liquid chromatography/electrospray ionization mass spectrometry : Analysis of CA and EA in plasma by HPLC-MS, 10.1002/bmc.3098
  98. Liu Qingwang, Zhao Di, Chen Xijing, Li Zhubo, Li Ning, Han Deen, Talbi Amer, Biwoele Tarcisse, Determination of Corosolic Acid, a Natural Potential Anti-Diabetes Compound, in Rat Plasma by High-Performance Liquid Chromatography-Mass Spectrometry and its Application to Pharmacokinetic and Bioavailability Studies, 10.1055/s-0030-1270993
  99. Du Zhiyong, Liu Zhenli, Ning Zhangchi, Liu Yuanyan, Song Zhiqian, Wang Chun, Lu Aiping, Prospects of Boswellic Acids as Potential Pharmaceutics, 10.1055/s-0034-1396313
  100. Shen Sida, Xu Xingyu, Liu Zhulong, Liu Junhua, Hu Lihong, Synthesis and structure–activity relationships of boswellic acid derivatives as potent VEGFR-2 inhibitors, 10.1016/j.bmc.2015.03.022
  101. Kumar Arvind, Qayum Arem, Sharma Parduman Raj, Singh Shashank Kumar, Shah Bhahwal Ali, Synthesis of β-boswellic acid derivatives as cytotoxic and apoptotic agents, 10.1016/j.bmcl.2015.11.027
  102. Sengupta Krishanu, Kolla Jayaprakash N., Krishnaraju Alluri V., Yalamanchili Nandini, Rao Chirravuri V., Golakoti Trimurtulu, Raychaudhuri Smriti, Raychaudhuri Siba P., Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract, 10.1007/s11010-011-0818-1
  103. Hüsch Jan, Bohnet Janine, Fricker Gert, Skarke Carsten, Artaria Christian, Appendino Giovanni, Schubert-Zsilavecz Manfred, Abdel-Tawab Mona, Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome®) of Boswellia extract, 10.1016/j.fitote.2012.10.002
  104. Bairwa Khemraj, Jachak Sanjay Madhukar, Development and optimisation of 3-Acetyl-11-keto-β-boswellic acid loaded poly-lactic-co-glycolic acid-nanoparticles with enhanced oral bioavailability and in-vivo anti-inflammatory activity in rats : Anti-inflammatory potential of AKBA-NPs, 10.1111/jphp.12420
  105. Mehta Meenu, Satija Saurabh, Nanda Arun, Garg Munish, Nanotechnologies for Boswellic Acids, 10.3923/ajdd.2014.1.11