Results from the Belgian mantle cell lymphoma registry.

Vergote, Vibeke Janssens, Ann André, Marc [UCL] Bonnet, Christophe Van Hende, Vanessa Van Den Neste, Eric [UCL] Van Eygen, Koen Maerevoet, Marie Pranger, Delphine Schroyens, Wilfried Debussche, Sarah Maertens, Vincent Beel, Karolien Lemmens, Jan Caron, Charlotte Delrieu, Vanessa Van Den Broeck, Isabelle Vanstraelen, Gaetan Jacquy, Caroline Schauvlieghe, Liesbeth De Samblanx, Hade Madoe, Vincent Meers, Stef Boulet, Dominique Verhoef, Gregor Van Hoof, Achiel et al.[show all]

(eng) INTRODUCTION: Mantle cell lymphoma is a B-cell non-Hodgkin's lymphoma characterized by a t(11;14), resulting in overexpression of cyclin D1. Conventional chemotherapy obtains frequent (but short) remissions, leading to a poor median overall survival (OS) of 3-5 years. To obtain more information about the prevalence and current treatment of Mantle cell lymphoma (MCL) in Belgium, we collected data in a Belgian registry of MCL. MATERIALS AND METHODS: All Belgian MCL patients, t(11;14) and/or cyclin D1 positive, seen in hematology departments over a one-year period (April 2013-March 2014) were included. Data about patient characteristics, histology, treatment lines, and response were compiled and retrospectively analyzed. RESULTS: Four hundred and four patients were included with a median age at diagnosis of 64 years (range 23-96 years) and a male predominance (72%). For 2013, we calculated a prevalence of at least 36.2 per million and an incidence of at least 7.0 per million in the Belgian population. Characteristics at diagnosis involved lymphadenopathy (82%), splenomegaly (44%), B-symptoms (39%), and hepatomegaly (10%). Bone marrow invasion was present at diagnosis in 77%. Stage at diagnosis was advanced in the majority of cases. The median number of treatment lines was 1. Type of first line treatment included a combination of anthracyclin and cytarabine-based regimen (34%), anthracyclin (39%), and other. Rituximab was used in 88% of first line treatments. In 44% first line treatment was followed by autologous stem cell transplantation. CONCLUSION: The analysis of this Belgian MCL registry provides insight in the epidemiology, demographics, and current treatment of our Belgian MCL population.