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La thérapie cellulaire du diabète : Le point sur les actualités

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Lysy, Philippe [UCL]

(fre) La possibilité de remplacer des cellules β déficientes par de nouvelles cellules insulino-sécrétantes chez le patient diabétique est démontrée par le succès de la transplantation d’îlots pancréatiques. Le manque de donneurs cadavériques a stimulé la recherche de sources alternatives de cellules β dont le palmarès est dominé par les cellules souches pluripotentes humaines pouvant acquérir des caractéristiques quasiment identiques à celles des cellules β et rétablir l’équilibre glycémique de souris diabétiques. Néanmoins, elles comportent un risque carcinogénique actuellement inévitable. Le pancréas adulte héberge des compartiments cellulaires aux capacités de transdifférenciation établies pouvant être exploitées pharmacologiquement in situ ou via des phases d’expansion en culture. Cette revue s’intéresse aux nouveaux développements concernant la thérapie cellulaire du diabète

(eng) [Cellular therapy of diabetes: focus on the latest developments]. Islet transplantation has set the ground for diabetes cell therapy and is still undergoing various developments that might improve clinical outcomes. Alternative sources for β-cell replacement strategies are now led by human pluripotent stem cells that demonstrate near-normal β-cell features after in vitro differentiation and which can reverse diabetes in mice. Yet, their propensity for tumor formation is still unresolved. The adult pancreas is suggested as a reservoir of facultative progenitors that could represent adequate candidates for β-cell engineering, either in vivo through pharmacological treatment or after expansion in culture. This review focuses on the latest developments in protocols aiming at de novo production of functional β cells.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2016
Language Français
Journal information "M/S : médecine sciences" - Vol. 32, no. 4, p. 401-407 (2016)
Peer reviewed yes
Publisher Editions médicales et scientifiques ((France) Paris)
issn 0767-0974
e-issn 1958-5381
Publication status Publié
Affiliations UCL - (SLuc) Service d'endocrinologie et diabétologie pédiatrique
UCL - SSS/IREC/PEDI - Pôle de Pédiatrie
Links
  1. Cameron Fergus J, Wherrett Diane K, Care of diabetes in children and adolescents: controversies, changes, and consensus, 10.1016/s0140-6736(15)60971-0
  2. Kelly, Surgery, 61, 827 (1967)
  3. Kaufman D. State of the art of solid organ pancreas transplantation. In: 75thScientific sessions of the American diabetes association. Boston, USA, 2015.
  4. Redfield Robert R., Scalea Joseph R., Odorico Jon S., Simultaneous pancreas and kidney transplantation : current trends and future directions, 10.1097/mot.0000000000000146
  5. Shapiro A.M. James, Lakey Jonathan R.T., Ryan Edmond A., Korbutt Gregory S., Toth Ellen, Warnock Garth L., Kneteman Norman M., Rajotte Ray V., Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen, 10.1056/nejm200007273430401
  6. Barton F. B., Rickels M. R., Alejandro R., Hering B. J., Wease S., Naziruddin B., Oberholzer J., Odorico J. S., Garfinkel M. R., Levy M., Pattou F., Berney T., Secchi A., Messinger S., Senior P. A., Maffi P., Posselt A., Stock P. G., Kaufman D. B., Luo X., Kandeel F., Cagliero E., Turgeon N. A., Witkowski P., Naji A., O'Connell P. J., Greenbaum C., Kudva Y. C., Brayman K. L., Aull M. J., Larsen C., Kay T. W. H., Fernandez L. A., Vantyghem M.-C., Bellin M., Shapiro A. M. J., Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010, 10.2337/dc12-0063
  7. Balamurugan A. N., Naziruddin B., Lockridge A., Tiwari M., Loganathan G., Takita M., Matsumoto S., Papas K., Trieger M., Rainis H., Kin T., Kay T. W., Wease S., Messinger S., Ricordi C., Alejandro R., Markmann J., Kerr-Conti J., Rickels M. R., Liu C., Zhang X., Witkowski P., Posselt A., Maffi P., Secchi A., Berney T., O'Connell P. J., Hering B. J., Barton F. B., Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010 : Islet Product Characteristics in CITR, 10.1111/ajt.12872
  8. Brennan DC, Kopetskie HA, Sayre PH,et al.Long-term follow-up of the Edmonton protocol of islet transplantation in the United States. Am J Transplant 2015.
  9. Ricordi C. Clinical islet transplantation update. In: 75thScientific sessions of the American diabetes association. Boston, USA, 2015.
  10. Inverardi L. Improved graft survival in islet transplant recipients treated with G-CSF (filgrastim) and exenatide. In: 75thScientific sessions of the American diabetes association. Boston, USA, 2015.
  11. Pepper Andrew R, Gala-Lopez Boris, Pawlick Rena, Merani Shaheed, Kin Tatsuya, Shapiro A M James, A prevascularized subcutaneous device-less site for islet and cellular transplantation, 10.1038/nbt.3211
  12. Hajizadeh-Saffar E., Tahamtani Y., Aghdami N., Azadmanesh K., Habibi-Anbouhi M., Heremans Y., De Leu N., Heimberg H., Ravassard P., Shokrgozar M. A., Baharvand H., Inducible VEGF Expression by Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Reduces the Minimal Islet Mass Required to Reverse Diabetes, 10.1038/srep09322
  13. Tomei Alice Anna, Villa Chiara, Ricordi Camillo, Development of an encapsulated stem cell-based therapy for diabetes, 10.1517/14712598.2015.1055242
  14. Kroon Evert, Martinson Laura A, Kadoya Kuniko, Bang Anne G, Kelly Olivia G, Eliazer Susan, Young Holly, Richardson Mike, Smart Nora G, Cunningham Justine, Agulnick Alan D, D'Amour Kevin A, Carpenter Melissa K, Baetge Emmanuel E, Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo, 10.1038/nbt1393
  15. D'Amour Kevin A, Bang Anne G, Eliazer Susan, Kelly Olivia G, Agulnick Alan D, Smart Nora G, Moorman Mark A, Kroon Evert, Carpenter Melissa K, Baetge Emmanuel E, Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells, 10.1038/nbt1259
  16. Fujikawa Takahisa, Oh Seh-Hoon, Pi Liya, Hatch Heather M., Shupe Tom, Petersen Bryon E., Teratoma Formation Leads to Failure of Treatment for Type I Diabetes Using Embryonic Stem Cell-Derived Insulin-Producing Cells, 10.1016/s0002-9440(10)62488-1
  17. Blum Barak, Benvenisty Nissim, The tumorigenicity of diploid and aneuploid human pluripotent stem cells, 10.4161/cc.8.23.10067
  18. Rezania A., Bruin J. E., Riedel M. J., Mojibian M., Asadi A., Xu J., Gauvin R., Narayan K., Karanu F., O'Neil J. J., Ao Z., Warnock G. L., Kieffer T. J., Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice, 10.2337/db11-1711
  19. Bruin Jennifer E., Rezania Alireza, Xu Jean, Narayan Kavitha, Fox Jessica K., O’Neil John J., Kieffer Timothy J., Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice, 10.1007/s00125-013-2955-4
  20. Rezania Alireza, Bruin Jennifer E, Arora Payal, Rubin Allison, Batushansky Irina, Asadi Ali, O'Dwyer Shannon, Quiskamp Nina, Mojibian Majid, Albrecht Tobias, Yang Yu Hsuan Carol, Johnson James D, Kieffer Timothy J, Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells, 10.1038/nbt.3033
  21. Pagliuca Felicia W., Millman Jeffrey R., Gürtler Mads, Segel Michael, Van Dervort Alana, Ryu Jennifer Hyoje, Peterson Quinn P., Greiner Dale, Melton Douglas A., Generation of Functional Human Pancreatic β Cells In Vitro, 10.1016/j.cell.2014.09.040
  22. Schwartz Steven D, Regillo Carl D, Lam Byron L, Eliott Dean, Rosenfeld Philip J, Gregori Ninel Z, Hubschman Jean-Pierre, Davis Janet L, Heilwell Gad, Spirn Marc, Maguire Joseph, Gay Roger, Bateman Jane, Ostrick Rosaleen M, Morris Debra, Vincent Matthew, Anglade Eddy, Del Priore Lucian V, Lanza Robert, Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies, 10.1016/s0140-6736(14)61376-3
  23. Osafune Kenji, Caron Leslie, Borowiak Malgorzata, Martinez Rita J, Fitz-Gerald Claire S, Sato Yasunori, Cowan Chad A, Chien Kenneth R, Melton Douglas A, Marked differences in differentiation propensity among human embryonic stem cell lines, 10.1038/nbt1383
  24. Mfopou Josué Kunjom, Chen Bing, Mateizel Ileana, Sermon Karen, Bouwens Luc, Noggin, Retinoids, and Fibroblast Growth Factor Regulate Hepatic or Pancreatic Fate of Human Embryonic Stem Cells, 10.1053/j.gastro.2010.02.056
  25. Gore Athurva, Li Zhe, Fung Ho-Lim, Young Jessica E., Agarwal Suneet, Antosiewicz-Bourget Jessica, Canto Isabel, Giorgetti Alessandra, Israel Mason A., Kiskinis Evangelos, Lee Je-Hyuk, Loh Yuin-Han, Manos Philip D., Montserrat Nuria, Panopoulos Athanasia D., Ruiz Sergio, Wilbert Melissa L., Yu Junying, Kirkness Ewen F., Belmonte Juan Carlos Izpisua, Rossi Derrick J., Thomson James A., Eggan Kevin, Daley George Q., Goldstein Lawrence S. B., Zhang Kun, Somatic coding mutations in human induced pluripotent stem cells, 10.1038/nature09805
  26. Maehr R., Chen S., Snitow M., Ludwig T., Yagasaki L., Goland R., Leibel R. L., Melton D. A., Generation of pluripotent stem cells from patients with type 1 diabetes, 10.1073/pnas.0906894106
  27. Teo Adrian K. K., Windmueller Rebecca, Johansson Bente B., Dirice Ercument, Njolstad Pal R., Tjora Erling, Raeder Helge, Kulkarni Rohit N., Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young, 10.1074/jbc.c112.428979
  28. Jiang Fang-Xu, Morahan Grant, Pancreatic Stem Cells Remain Unresolved, 10.1089/scd.2014.0214
  29. Lysy Philippe A., Weir Gordon C., Bonner-Weir Susan, Making β Cells from Adult Cells Within the Pancreas, 10.1007/s11892-013-0400-1
  30. Vetere Amedeo, Choudhary Amit, Burns Sean M., Wagner Bridget K., Targeting the pancreatic β-cell to treat diabetes, 10.1038/nrd4231
  31. Gershengorn M. C., Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells, 10.1126/science.1101968
  32. Russ Holger A., Sintov Elad, Anker-Kitai Leeat, Friedman Orr, Lenz Ayelet, Toren Ginat, Farhy Chen, Pasmanik-Chor Metsada, Oron-Karni Varda, Ravassard Philippe, Efrat Shimon, Insulin-Producing Cells Generated from Dedifferentiated Human Pancreatic Beta Cells Expanded In Vitro, 10.1371/journal.pone.0025566
  33. Bar Yael, Russ Holger A., Sintov Elad, Anker-Kitai Leeat, Knoller Sarah, Efrat Shimon, Redifferentiation of Expanded Human Pancreatic β-Cell-derived Cells by Inhibition of the NOTCH Pathway, 10.1074/jbc.m111.319152
  34. Smukler Simon R., Arntfield Margot E., Razavi Rozita, Bikopoulos George, Karpowicz Phillip, Seaberg Raewyn, Dai Feihan, Lee Simon, Ahrens Rosemary, Fraser Paul E., Wheeler Michael B., van der Kooy Derek, The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin, 10.1016/j.stem.2011.01.015
  35. Razavi Rozita, Najafabadi Hamed S., Abdullah Sarah, Smukler Simon, Arntfield Margot, van der Kooy Derek, Diabetes Enhances the Proliferation of Adult Pancreatic Multipotent Progenitor Cells and Biases Their Differentiation to More β-Cell Production, 10.2337/db14-0070
  36. Brereton Melissa F., Vergari Elisa, Zhang Quan, Clark Anne, Alpha-, Delta- and PP-cells : Are They the Architectural Cornerstones of Islet Structure and Co-ordination?, 10.1369/0022155415583535
  37. Collombat Patrick, Xu Xiaobo, Ravassard Philippe, Sosa-Pineda Beatriz, Dussaud Sébastien, Billestrup Nils, Madsen Ole D., Serup Palle, Heimberg Harry, Mansouri Ahmed, The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells, 10.1016/j.cell.2009.05.035
  38. Thorel Fabrizio, Népote Virginie, Avril Isabelle, Kohno Kenji, Desgraz Renaud, Chera Simona, Herrera Pedro L., Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss, 10.1038/nature08894
  39. Habener Joel F., Stanojevic Violeta, Alpha cells come of age, 10.1016/j.tem.2012.10.009
  40. Courtney Monica, Gjernes Elisabet, Druelle Noémie, Ravaud Christophe, Vieira Andhira, Ben-Othman Nouha, Pfeifer Anja, Avolio Fabio, Leuckx Gunter, Lacas-Gervais Sandra, Burel-Vandenbos Fanny, Ambrosetti Damien, Hecksher-Sorensen Jacob, Ravassard Philippe, Heimberg Harry, Mansouri Ahmed, Collombat Patrick, The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells, 10.1371/journal.pgen.1003934
  41. Baeyens L., Bouwens L., Can β-cells be derived from exocrine pancreas?, 10.1111/j.1463-1326.2008.00949.x
  42. Desai Biva M., Oliver-Krasinski Jennifer, De Leon Diva D., Farzad Cyrus, Hong Nankang, Leach Steven D., Stoffers Doris A., Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration, 10.1172/jci29988
  43. Murtaugh L. Charles, Keefe Matthew D., Regeneration and Repair of the Exocrine Pancreas, 10.1146/annurev-physiol-021014-071727
  44. Zhou Qiao, Brown Juliana, Kanarek Andrew, Rajagopal Jayaraj, Melton Douglas A., In vivo reprogramming of adult pancreatic exocrine cells to β-cells, 10.1038/nature07314
  45. Li Weida, Cavelti-Weder Claudia, Zhang Yinying, Clement Kendell, Donovan Scott, Gonzalez Gabriel, Zhu Jiang, Stemann Marianne, Xu Ke, Hashimoto Tatsu, Yamada Takatsugu, Nakanishi Mio, Zhang Yuemei, Zeng Samuel, Gifford David, Meissner Alexander, Weir Gordon, Zhou Qiao, Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells, 10.1038/nbt.3082
  46. Yamada Takatsugu, Cavelti-Weder Claudia, Caballero Francisco, Lysy Philippe A., Guo Lili, Sharma Arun, Li Weida, Zhou Qiao, Bonner-Weir Susan, Weir Gordon C., Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells, 10.1210/en.2014-1987
  47. Rooman I., Bouwens L., Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan, 10.1007/s00125-003-1287-1
  48. Baeyens Luc, Lemper Marie, Leuckx Gunter, De Groef Sofie, Bonfanti Paola, Stangé Geert, Shemer Ruth, Nord Christoffer, Scheel David W, Pan Fong C, Ahlgren Ulf, Gu Guoqiang, Stoffers Doris A, Dor Yuval, Ferrer Jorge, Gradwohl Gerard, Wright Christopher V E, Van de Casteele Mark, German Michael S, Bouwens Luc, Heimberg Harry, Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice, 10.1038/nbt.2747
  49. Ray K C, Moss M E, Franklin J L, Weaver C J, Higginbotham J, Song Y, Revetta F L, Blaine S A, Bridges L R, Guess K E, Coffey R J, Crawford H C, Washington M K, Means A L, Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia, 10.1038/onc.2013.3
  50. Pan Fong Cheng, Wright Chris, Pancreas organogenesis: From bud to plexus to gland, 10.1002/dvdy.22584
  51. Xu Xiaobo, D'Hoker Joke, Stangé Geert, Bonné Stefan, De Leu Nico, Xiao Xiangwei, Van De Casteele Mark, Mellitzer Georg, Ling Zhidong, Pipeleers Danny, Bouwens Luc, Scharfmann Raphael, Gradwohl Gerard, Heimberg Harry, β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas, 10.1016/j.cell.2007.12.015
  52. Bonner-Weir Susan, Guo Lili, Li Wan-Chun, Ouziel-Yahalom Limor, Weir Gordon C., Sharma Arun, Islet Neogenesis: A Possible Pathway for Beta-Cell Replenishment, 10.1900/rds.2012.9.407
  53. Esposito Irene, Segler Angela, Steiger Katja, Klöppel Günter, Pathology, genetics and precursors of human and experimental pancreatic neoplasms: An update, 10.1016/j.pan.2015.08.007
  54. Yatoh S., Dodge R., Akashi T., Omer A., Sharma A., Weir G. C., Bonner-Weir S., Differentiation of Affinity-Purified Human Pancreatic Duct Cells to  -Cells, 10.2337/db06-1670
  55. Lee, Elife, 2, e00940 (2013)
  56. Bonner-Weir S., Taneja M., Weir G. C., Tatarkiewicz K., Song K.-H., Sharma A., O'Neil J. J., In vitro cultivation of human islets from expanded ductal tissue, 10.1073/pnas.97.14.7999
  57. Seeberger Karen L, Dufour Jannette M, Shapiro Andrew M James, Lakey Jonathan R T, Rajotte Ray V, Korbutt Gregory S, Expansion of mesenchymal stem cells from human pancreatic ductal epithelium, 10.1038/labinvest.3700377
  58. Corritore Elisa, Dugnani Erica, Pasquale Valentina, Misawa Ryosuke, Witkowski Piotr, Lei Ji, Markmann James, Piemonti Lorenzo, Sokal Etienne M., Bonner-Weir Susan, Lysy Philippe A., β-Cell Differentiation of Human Pancreatic Duct–Derived Cells AfterIn VitroExpansion, 10.1089/cell.2014.0025
  59. Franc Carine, Le diabète : Des chiffres alarmants, 10.1051/medsci/2013298008
  60. Velho Gilberto, Bellanné-Chantelot Christine, Timsit José, Le MODY : modèle d’étude d’interactions génotype/phénotype dans le diabète de type 2, 10.1051/medsci/20031989854
  61. Thorel Fabrizio, Herrera Pedro L., Génération de cellules β-pancréatiques par conversion spontanée de cellules α chez des souris diabétiques, 10.1051/medsci/20102611906
Bibliographic reference Lysy, Philippe. La thérapie cellulaire du diabète : Le point sur les actualités. In: M/S : médecine sciences, Vol. 32, no. 4, p. 401-407 (2016)
Permanent URL http://hdl.handle.net/2078.1/182915