User menu

NRP-1 Receptor Expression Mismatch in Skin of Subjects with Experimental and Diabetic Small Fiber Neuropathy

Bibliographic reference Van Acker, Nathalie ; Rage, Michaël ; Vermeirsch, Hilde ; Schrijvers, Dorien ; Nuydens, Rony ; et. al. NRP-1 Receptor Expression Mismatch in Skin of Subjects with Experimental and Diabetic Small Fiber Neuropathy. In: PLoS One, Vol. 11, no.9, p. e0161441 (2016)
Permanent URL
  1. S Chanda, Drug Metab Dispos, 36, 670 (2008)
  2. CH Gibbons, Ann Neurol, 68, 888 (2010)
  3. Mason L., Systematic review of topical capsaicin for the treatment of chronic pain, 10.1136/
  4. Anand P., Bley K., Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch, 10.1093/bja/aer260
  5. Polydefkis M., Sirdofsky M., Hauer P., Petty B. G., Murinson B., McArthur J. C., Factors influencing nerve regeneration in a trial of timcodar dimesylate, 10.1212/01.wnl.0000194209.37604.57
  6. M Ragé, Clin Neurophysiol. International Federation of Clinical Neurophysiology (2010)
  7. M Polydefkis, Brain, 127, 1606 (2004)
  8. Chanda S., Bashir M., Babbar S., Koganti A., Bley K., In Vitro Hepatic and Skin Metabolism of Capsaicin, 10.1124/dmd.107.019240
  9. Nolano Maria, Simone Donald A., Wendelschafer-Crabb Gwen, Johnson Timothy, Hazen Eric, Kennedy William R., Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation : , 10.1016/s0304-3959(99)00007-x
  10. Polydefkis Michael, Hauer Peter, Sheth Soham, Sirdofsky Michael, Griffin John W., McArthur Justin C., The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy, 10.1093/brain/awh175
  11. Gibbons Christopher H., Wang Ningshan, Freeman Roy, Capsaicin induces degeneration of cutaneous autonomic nerve fibers, 10.1002/ana.22126
  12. Lauria G., Cornblath D. R., Johansson O., McArthur J. C., Mellgren S. I., Nolano M., Rosenberg N., Sommer C., EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy, 10.1111/j.1468-1331.2005.01260.x
  13. Quattrini C., Jeziorska M., Boulton A. J.M., Malik R. A., Reduced Vascular Endothelial Growth Factor Expression and Intra-Epidermal Nerve Fiber Loss in Human Diabetic Neuropathy, 10.2337/dc07-1556
  14. Umapathi T., Tan Wan Loo, Loke Seng Cheong, Soon Puay Cheow, Tavintharan S., Chan Yiong Huak, Intraepidermal nerve fiber density as a marker of early diabetic neuropathy, 10.1002/mus.20732
  15. Hartemann A., Attal N., Bouhassira D., Dumont I., Gin H., Jeanne S., Said G., Richard J.-L., Painful diabetic neuropathy: Diagnosis and management, 10.1016/j.diabet.2011.06.003
  16. Shun Chia‐Tung, Chang Yang‐Chyuan, Wu Huey‐Peir, Hsieh Song‐Chou, Lin Whei‐Min, Lin Yea‐Hui, Tai Tong‐Yuan, Hsieh Sung‐Tsang, Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments, 10.1093/brain/awh180
  17. M Polydefkis, Contemporary Diabetes: Diabetic Neuropathy: Clinical Management, Second Edition, 293 (2007)
  18. Divisova Sarka, Vlckova Eva, Hnojcikova Maria, Skorna Miroslav, Nemec Martin, Dubovy Petr, Dusek Ladislav, Jarkovsky Jiri, Belobradkova Jana, Bednarik Josef, Prediabetes/early diabetes-associated neuropathy predominantly involves sensory small fibres, 10.1111/j.1529-8027.2012.00420.x
  19. Quattrini Cristian, Tavakoli Mitra, Jeziorska Maria, Kallinikos Panagiotis, Tesfaye Solomon, Finnigan Joanne, Marshall Andrew, Boulton Andrew J.M., Efron Nathan, Malik Rayaz A., Surrogate Markers of Small Fiber Damage in Human Diabetic Neuropathy, 10.2337/db07-0285
  20. Vlckova-Moravcova E., Bednarik J., Belobradkova J., Sommer C., Small-fibre involvement in diabetic patients with neuropathic foot pain, 10.1111/j.1464-5491.2008.02446.x
  21. Narayanaswamy H., Facer P., Misra V.P., Timmers M., Byttebier G., Meert T., Anand P., A longitudinal study of sensory biomarkers of progression in patients with diabetic peripheral neuropathy using skin biopsies, 10.1016/j.jocn.2011.12.026
  22. TAVEE J., ZHOU L., Small fiber neuropathy: A burning problem, 10.3949/ccjm.76a.08070
  23. JW Russell, Continuum (Minneap Minn), 20, 1226 (2014)
  24. Oyenihi Ayodeji Babatunde, Ayeleso Ademola Olabode, Mukwevho Emmanuel, Masola Bubuya, Antioxidant Strategies in the Management of Diabetic Neuropathy, 10.1155/2015/515042
  25. A Aslam, Pain Res Treat, 2014 (2014)
  26. Verkhratsky Alexei, Fernyhough Paul, Calcium signalling in sensory neurones and peripheral glia in the context of diabetic neuropathies, 10.1016/j.ceca.2014.07.005
  27. Kaku Michelle, Vinik Aaron, Simpson David M., Pathways in the Diagnosis and Management of Diabetic Polyneuropathy, 10.1007/s11892-015-0609-2
  28. Cashman Christopher R., Höke Ahmet, Mechanisms of distal axonal degeneration in peripheral neuropathies, 10.1016/j.neulet.2015.01.048
  29. S Tesfaye, Proceedings, 4, 1014 (2004)
  30. RAAM Alik, Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments, 33 (2010)
  31. CYL Chao, Diabetes Metab Res Rev, 25, 604 (2009)
  32. Chao Clare Y. L., Cheing Gladys L. Y., Microvascular dysfunction in diabetic foot disease and ulceration, 10.1002/dmrr.1004
  33. Vinik A. I., Erbas T., Park T. S., Stansberry K. B., Scanelli J. A., Pittenger G. L., Dermal Neurovascular Dysfunction in Type 2 Diabetes, 10.2337/diacare.24.8.1468
  34. Thangarajah H., Yao D., Chang E. I., Shi Y., Jazayeri L., Vial I. N., Galiano R. D., Du X.-L., Grogan R., Galvez M. G., Januszyk M., Brownlee M., Gurtner G. C., The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues, 10.1073/pnas.0906670106
  35. Botusan I. R., Sunkari V. G., Savu O., Catrina A. I., Grunler J., Lindberg S., Pereira T., Yla-Herttuala S., Poellinger L., Brismar K., Catrina S.-B., Stabilization of HIF-1  is critical to improve wound healing in diabetic mice, 10.1073/pnas.0805230105
  36. Krishnan S. T.M., Quattrini C., Jeziorska M., Malik R. A., Rayman G., Neurovascular Factors in Wound Healing in the Foot Skin of Type 2 Diabetic Subjects, 10.2337/dc07-1421
  37. Xiao Haijuan, Gu Zhenyang, Wang Guoxing, Zhao Tongfeng, The Possible Mechanisms Underlying the Impairment of HIF-1α Pathway Signaling in Hyperglycemia and the Beneficial Effects of Certain Therapies, 10.7150/ijms.5630
  38. MI Yusof, Singapore Med J, 49, 100 (2008)
  39. Mahdy R A, Nada W M, Hadhoud K M, El-Tarhony S A, The role of vascular endothelial growth factor in the progression of diabetic vascular complications, 10.1038/eye.2010.86
  40. Vas P. R. J., Green A. Q., Rayman G., Small fibre dysfunction, microvascular complications and glycaemic control in type 1 diabetes: a case–control study, 10.1007/s00125-011-2417-9
  41. Klagsbrun Michael, Eichmann Anne, A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis, 10.1016/j.cytogfr.2005.05.002
  42. F De Smet, Arterioscler Thromb Vasc Biol, 29, 639 (2009)
  43. Neufeld G, The Neuropilins Multifunctional Semaphorin and VEGF Receptors that Modulate Axon Guidance and Angiogenesis, 10.1016/s1050-1738(01)00140-2
  44. Ruiz de Almodovar C., Lambrechts D., Mazzone M., Carmeliet P., Role and Therapeutic Potential of VEGF in the Nervous System, 10.1152/physrev.00031.2008
  45. Carmeliet Peter, De Smet Frederik, Loges Sonja, Mazzone Massimiliano, Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way, 10.1038/nrclinonc.2009.64
  46. De Smet F., Segura I., De Bock K., Hohensinner P. J., Carmeliet P., Mechanisms of Vessel Branching: Filopodia on Endothelial Tip Cells Lead the Way, 10.1161/atvbaha.109.185165
  47. Ebenezer G. J., O'Donnell R., Hauer P., Cimino N. P., McArthur J. C., Polydefkis M., Impaired neurovascular repair in subjects with diabetes following experimental intracutaneous axotomy, 10.1093/brain/awr086
  48. Carmeliet Peter, Tessier-Lavigne Marc, Common mechanisms of nerve and blood vessel wiring, 10.1038/nature03875
  50. Mukouyama Y.-s., Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback, 10.1242/dev.01675
  51. Ragé Michael, Acker Nathalie, Knaapen Michiel W. M., Timmers Maarten, Streffer Johannes, Hermans Michel P., Sindic Christian, Meert Theo, Plaghki Léon, Asymptomatic small fiber neuropathy in diabetes mellitus: investigations with intraepidermal nerve fiber density, quantitative sensory testing and laser-evoked potentials, 10.1007/s00415-011-6031-z
  52. L Yuan, Development, 129, 4797 (2002)
  53. Matthies Annette M., Low Quentin E.H., Lingen Mark W., DiPietro Luisa A., Neuropilin-1 Participates in Wound Angiogenesis, 10.1016/s0002-9440(10)64372-6
  54. Pellet-Many Caroline, Frankel Paul, Evans Ian M., Herzog Birger, Jünemann-Ramírez Manfred, Zachary Ian C., Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas, 10.1042/bj20100580
  55. Y Cao, Neuropilin-1 Mediates Divergent R-Smad Signaling and the, 285, 31840 (2010)
  56. Kou K, Nakamura F, Aihara M, Chen H, Seto K, Komori-Yamaguchi J, Kambara T, Nagashima Y, Goshima Y, Ikezawa Z, Decreased Expression of Semaphorin-3A, a Neurite-Collapsing Factor, is Associated With Itch in Psoriatic Skin, 10.2340/00015555-1350
  57. X-Y Man, Mol Med, 12, 127 (2006)
  58. Riese Anna, Eilert Yvonne, Meyer Yvonne, Arin Meral, Baron Jens M., Eming Sabine, Krieg Thomas, Kurschat Peter, Epidermal Expression of Neuropilin 1 Protects Murine keratinocytes from UVB-induced apoptosis, 10.1371/journal.pone.0050944
  59. S Shahrabi-Farahani, Lab Invest, 00, 1 (2014)
  60. Kurschat Peter, Bielenberg Diane, Rossignol-Tallandier Mireille, Stahl Andreas, Klagsbrun Michael, Neuron Restrictive Silencer Factor NRSF/REST Is a Transcriptional Repressor of Neuropilin-1 and Diminishes the Ability of Semaphorin 3A to Inhibit Keratinocyte Migration, 10.1074/jbc.m507860200
  61. Marfella Raffaele, Sasso Ferdinando Carlo, Rizzo Maria Rosaria, Paolisso Pasquale, Barbieri Michelangela, Padovano Vincenzo, Carbonara Ornella, Gualdiero Pasquale, Petronella Pasquale, Ferraraccio Franca, Petrella Antonello, Canonico Raffaele, Campitiello Ferdinando, Della Corte Angela, Paolisso Giuseppe, Canonico Silvestro, Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes, 10.1155/2012/892706
  62. Nabavi Nouri Maryam, Ahmed Ausma, Bril Vera, Orszag Andrej, Ng Eduardo, Nwe Patti, Perkins Bruce A., Diabetic Neuropathy and Axon Reflex-Mediated Neurogenic Vasodilatation in Type 1 Diabetes, 10.1371/journal.pone.0034807
  63. Light A. R., "Nocifensor" System Re-Revisited. Focus on "Two Types of C Nociceptor in Human Skin and Their Behavior in Areas of Capaicin-Induced Secondary Hyperalgesia", 10.1152/jn.00090.2004
  64. Dux Mária, Sántha Péter, Jancsó Gábor, Capsaicin-sensitive neurogenic sensory vasodilatation in the dura mater of the rat, 10.1113/jphysiol.2003.050633
  65. Z Bagi, Tissue-Specific Regulation of Microvascular Diameter: Opposite Functional Roles of Neuronal and Smooth Muscle Located Vanilloid Receptor-1, 73, 1405 (2008)
  66. Han Ping, McDonald Heath A., Bianchi Bruce R., Kouhen Rachid El, Vos Melissa H., Jarvis Michael F., Faltynek Connie R., Moreland Robert B., Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes, 10.1016/j.bcp.2006.12.035
  67. Raimondi Claudio, Brash James T., Fantin Alessandro, Ruhrberg Christiana, NRP1 function and targeting in neurovascular development and eye disease, 10.1016/j.preteyeres.2016.02.003
  68. Rosenzweig Shira, Raz-Prag Dorit, Nitzan Anat, Galron Ronit, Paz Ma’ayan, Jeserich Gunnar, Neufeld Gera, Barzilai Ari, Solomon Arieh S., Sema-3A indirectly disrupts the regeneration process of goldfish optic nerve after controlled injury, 10.1007/s00417-010-1377-y
  69. Goshima Yoshio, Sasaki Yukio, Nakayama Takashi, Ito Takaaki, Kimura Toru, Curret Perspective. Functions of Semaphorins in Axon Guidance and Neuronal Regeneration., 10.1254/jjp.82.273
  70. RJ Pasterkamp, J Neurosci, 18, 9962 (1998)
  71. Tominaga Mitsutoshi, Tengara Suhandy, Kamo Atsuko, Ogawa Hideoki, Takamori Kenji, Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis, 10.1016/j.jdermsci.2009.03.007
  72. Carmeliet Peter, de Almodovar Carmen Ruiz, VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration, 10.1007/s00018-013-1283-7
  73. Masuda Tomoyuki, Shiga Takashi, Chemorepulsion and cell adhesion molecules in patterning initial trajectories of sensory axons, 10.1016/j.neures.2005.01.007
  74. Tolofari SK, Richardson SM, Freemont AJ, Hoyland JA. Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc. 2010; 1–11.
  75. AA Kubanov, Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis, 159, 318 (2015)
  76. Tominaga M., Ogawa H., Takamori K., Decreased production of semaphorin 3A in the lesional skin of atopic dermatitis, 10.1111/j.1365-2133.2007.08410.x
  77. Yamaguchi Junko, Nakamura Fumio, Aihara Michiko, Yamashita Naoya, Usui Hiroshi, Hida Tomonobu, Takei Kohtaro, Nagashima Yoji, Ikezawa Zenro, Goshima Yoshio, Semaphorin3A Alleviates Skin Lesions and Scratching Behavior in NC/Nga Mice, an Atopic Dermatitis Model, 10.1038/jid.2008.150