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SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study

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Dugernier, Jonathan [UCL] Hesse, Michel [UCL] Vanbever, Rita [UCL] Depoortere, Virginie Roeseler, Jean [UCL] Michotte, Jean-Bernard [UCL] Laterre, Pierre-François [UCL] Jamar, François [UCL] Reychler, Gregory [UCL]

(eng) PURPOSE: To compare in vivo the total and regional pulmonary deposition of aerosol particles generated by a new system combining a vibrating-mesh nebulizer with a specific valved holding chamber and constant-output jet nebulizer connected to a corrugated tube. METHODS: Cross-over study comparing aerosol delivery to the lungs using two nebulizers in 6 healthy male subjects: a vibrating-mesh nebulizer combined with a valved holding chamber (Aerogen Ultra®, Aerogen Ltd., Galway, Ireland) and a jet nebulizer connected to a corrugated tube (Opti-Mist Plus Nebulizer®, ConvaTec, Bridgewater, NJ). Nebulizers were filled with diethylenetriaminepentaacetic acid labelled with technetium-99 m (99mTc-DTPA, 2 mCi/4 mL). Pulmonary deposition of 99mTc-DTPA was measured by single-photon emission computed tomography combined with a low dose CT-scan (SPECT-CT). RESULTS: Pulmonary aerosol deposition from SPECT-CT analysis was six times increased with the vibrating-mesh nebulizer as compared to the jet nebulizer (34.1 ± 6.0% versus 5.2 ± 1.1%, p < 0.001). However, aerosol penetration expressed as the three-dimensional normalized ratio of the outer and the inner regions of the lungs was similar between both nebulizers. CONCLUSIONS: This study demonstrated the high superiority of the new system combining a vibrating-mesh nebulizer with a valved holding chamber to deliver nebulized particles into the lungs as comparted to a constant-output jet nebulizer with a corrugated tube.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès interdit
Publication date 2017
Language Anglais
Journal information "Pharmaceutical Research" - Vol. 34, no. 2, p. 290-300 (2017)
Peer reviewed yes
Publisher Springer New York LLC ((United States) New York, NY)
issn 0724-8741
e-issn 1573-904X
Publication status Publié
Affiliations UCL - SSS/IREC/LUNS - Pôle pneumologie, ORL (airways) et dermatologie (skin)
UCL - SSS/IREC/MEDA - Pôle de médecine aiguë
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - SSS/LDRI - Louvain Drug Research Institute
UCL - (SLuc) Service de soins intensifs
UCL - (SLuc) Service de médecine nucléaire
UCL - (SLuc) Service de médecine physique et de réadaptation motrice
UCL - (SLuc) Service de pneumologie
Keywords Aerosol delivery ; Healthy subjects ; Single photon emission computed tomography ; Spacer ; Vibrating-mesh nebulizer
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Bibliographic reference Dugernier, Jonathan ; Hesse, Michel ; Vanbever, Rita ; Depoortere, Virginie ; Roeseler, Jean ; et. al. SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study. In: Pharmaceutical Research, Vol. 34, no. 2, p. 290-300 (2017)
Permanent URL http://hdl.handle.net/2078.1/182252