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Restoring Fertility with Cryopreserved Prepubertal Testicular Tissue: Perspectives with Hydrogel Encapsulation, Nanotechnology, and Bioengineered Scaffolds

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Vermeulen, Maxime [UCL] Poels, Jonathan [UCL] De Michele, Francesca [UCL] des Rieux, Anne [UCL] Wyns, Christine [UCL]

New and improved oncological therapies are now able to cure more than 80% of cancer-affected children in Europe. However, such treatments are gonadotoxic and result in fertility issues, especially in boys who are not able to provide a sperm sample before starting chemo/radiotherapy because of their prepubertal state. For these boys, cryopreservation of immature testicular tissue (ITT) is the only available option, aiming to preserve spermatogonial stem cells (SSCs). Both slow-freezing and vitrification have been investigated to this end and are now applied in a clinical setting for SSC cryopreservation. Research now has to focus on methods that will allow fertility restoration. This review discusses different studies that have been conducted on ITT transplantation, including those using growth factor supplementation like free molecules, or tissue encapsulation with or without nanoparticles, as well as the possibility of developing a bioartificial testis that can be used for in vitro gamete production or in vivo transplantation.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2017
Language Anglais
Journal information "Annals of Biomedical Engineering" - Vol. 45, no. 7, p. 1770-1781 (2017)
Peer reviewed yes
Publisher Springer New York LLC ((United States) New York, NY)
issn 0090-6964
e-issn 1573-9686
Publication status Publié
Affiliations UCL - SSS/IREC/GYNE - Pôle de Gynécologie
UCL - SSS/LDRI - Louvain Drug Research Institute
UCL - (SLuc) Service de gynécologie et d'andrologie
Keywords Cryopreservation ; Encapsulation ; Extracellular matrix ; Fertility preservation ; Hydrogels ; Testicular transplantation
Links
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Bibliographic reference Vermeulen, Maxime ; Poels, Jonathan ; De Michele, Francesca ; des Rieux, Anne ; Wyns, Christine. Restoring Fertility with Cryopreserved Prepubertal Testicular Tissue: Perspectives with Hydrogel Encapsulation, Nanotechnology, and Bioengineered Scaffolds. In: Annals of Biomedical Engineering, Vol. 45, no. 7, p. 1770-1781 (2017)
Permanent URL http://hdl.handle.net/2078.1/182233