User menu

Inflammation induced by inhaled lipopolysaccharide depends on particle size in healthy volunteers

Bibliographic reference Doyen, Virginie ; Pilcer, Gabrielle ; Dinh, Phong Huy Duc ; Corazza, Francis ; Bernard, Alfred ; et. al. Inflammation induced by inhaled lipopolysaccharide depends on particle size in healthy volunteers. In: British Journal of Clinical Pharmacology, Vol. 82, no.5, p. 1371-1381 (2016)
Permanent URL
  1. Kitz Richard, Rose Markus A., Placzek Katja, Schulze Johannes, Zielen Stefan, Schubert Ralf, LPS inhalation challenge: a new tool to characterize the inflammatory response in humans, 10.1007/s00430-007-0053-2
  2. Aul Raminder, Armstrong Jane, Duvoix Annelyse, Lomas David, Hayes Brian, Miller Bruce E., Jagger Chris, Singh Dave, Inhaled LPS challenges in smokers: a study of pulmonary and systemic effects : Inhaled LPS challenge in smokers, 10.1111/j.1365-2125.2012.04287.x
  3. Gupta Vandana, Banyard Antonia, Mullan Aoibheann, Sriskantharajah Srividya, Southworth Thomas, Singh Dave, Characterization of the inflammatory response to inhaled lipopolysaccharide in mild to moderate chronic obstructive pulmonary disease : Inhaled LPS in COPD, 10.1111/bcp.12546
  4. MICHEL OLIVIER, NAGY ANNE-MARIE, SCHROEVEN MARC, DUCHATEAU JEAN, NÈVE JEAN, FONDU PIERRE, SERGYSELS ROGER, Dose-Response Relationship to Inhaled Endotoxin in Normal Subjects, 10.1164/ajrccm.156.4.97-02002
  5. Doyen Virginie, Kassengera Zaina, Dinh Duc Huy Phong, Michel Olivier, Time Course of Endotoxin-Induced Airways’ Inflammation in Healthy Subjects, 10.1007/s10753-010-9286-0
  6. Aul Raminder, Patel Sheena, Summerhill Susan, Kilty Iain, Plumb Jonathan, Singh Dave, LPS challenge in healthy subjects: An investigation of neutrophil chemotaxis mechanisms involving CXCR1 and CXCR2, 10.1016/j.intimp.2012.04.008
  7. Degobbi Cristiane, Saldiva Paulo Hilário Nascimento, Rogers Christine, Endotoxin as modifier of particulate matter toxicity: a review of the literature, 10.1007/s10453-010-9179-6
  8. Errea Agustina, González Maciel Dolores, Hiriart Yanina, Hozbor Daniela, Rumbo Martin, Intranasal administration of TLR agonists induces a discriminated local innate response along murine respiratory tract, 10.1016/j.imlet.2015.01.004
  9. Lieutier-Colas Florence, Purohit Ashok, Meyer Pierre, Fabries Jean-François, Kopferschmitt Marie-Christine, Dessanges Jean-François, Pauli Gabrielle, de Blay Frédéric, Bronchial Challenge Tests in Patients with Asthma Sensitized to Cats : The Importance of Large Particles in the Immediate Response, 10.1164/rccm.2204037
  10. European Pharmacopoeia 7th edn
  11. Michel, J Appl Physiol, 66, 1059 (1989)
  12. Newman Stephen P., Pitcairn Gary R., Hirst Peter H., Rankin Lisa, Radionuclide imaging technologies and their use in evaluating asthma drug deposition in the lungs, 10.1016/s0169-409x(03)00081-4
  13. Michel Olivier, Doyen Virginie, Leroy Baptiste, Bopp Benjamin, Dinh Duc Huy Phong, Corazza Francis, Wattiez Ruddy, Expression of calgranulin A/B heterodimer after acute inhalation of endotoxin: proteomic approach and validation, 10.1186/1471-2466-13-65
  14. Michel Olivier, Murdoch Robert, Bernard Alfred, Inhaled LPS induces blood release of Clara cell specific protein (CC16) in human beings, 10.1016/j.jaci.2005.01.067
  15. Möller Winfried, Heimbeck Irene, Hofer Thomas P. J., Khadem Saba Gülnaz, Neiswirth Margot, Frankenberger Marion, Ziegler-Heitbrock Löms, Differential Inflammatory Response to Inhaled Lipopolysaccharide Targeted Either to the Airways or the Alveoli in Man, 10.1371/journal.pone.0033505
  16. Janssen Ole, Schaumann Frank, Holz Olaf, Lavae-Mokhtari Bianca, Welker Lutz, Winkler Carla, Biller Heike, Krug Norbert, Hohlfeld Jens M, Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development, 10.1186/1471-2466-13-19
  17. Darquenne Chantal, Aerosol Deposition in Health and Disease, 10.1089/jamp.2011.0916
  18. Carvalho Thiago C., Peters Jay I., Williams III Robert O., Influence of particle size on regional lung deposition – What evidence is there?, 10.1016/j.ijpharm.2010.12.040
  19. Labiris N. R., Dolovich M. B., Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications : Physiological factors affecting the effectiveness of inhaled drugs, 10.1046/j.1365-2125.2003.01892.x
  20. Mishra Anil, Hogan Simon P., Brandt Eric B., Rothenberg Marc E., An etiological role for aeroallergens and eosinophils in experimental esophagitis, 10.1172/jci10224
  21. Brand P., Friemel I., Meyer T., Schulz H., Heyder J., Häuβinger K., Total Deposition of Therapeutic Particles During Spontaneous and Controlled Inhalations, 10.1002/(sici)1520-6017(200006)89:6<724::aid-jps3>;2-b
  22. Zeman Kirby L., Wu Jihong, Bennett William D., Targeting Aerosolized Drugs to the Conducting Airways Using Very Large Particles and Extremely Slow Inhalations, 10.1089/jamp.2008.0711
  23. Forbes L. R., Haczku A., SP-D and regulation of the pulmonary innate immune system in allergic airway changes : SP-D and airway inflammation, 10.1111/j.1365-2222.2010.03483.x
  24. Keese Susanne P, Brandenburg Klaus, Roessle Manfred, Schromm Andra B, Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages, 10.1177/1753425913506269
  25. Widmeier Susanne, Bernard Alfred, Tschopp Alois, Jeggli Stefan, Dumont Xavier, Hilfiker Silvia, Oppliger Anne, Hotz Philippe, Surfactant Protein A, Exposure to Endotoxin, and Asthma in Garbage Collectors and in Wastewater Workers, 10.1080/08958370601144456
  26. McAlees J W, Whitehead G S, Harley I TW, Cappelletti M, Rewerts C L, Holdcroft A M, Divanovic S, Wills-Karp M, Finkelman F D, Karp C L, Cook D N, Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation, 10.1038/mi.2014.117
  27. Zielen Stefan, Trischler Jordis, Schubert Ralf, Lipopolysaccharide challenge: immunological effects and safety in humans, 10.1586/1744666x.2015.1012158
  28. Herbert Alex, Carvalheiro Maria, Rubenowitz Eva, Bake Björn, Rylander Ragnar, Reduction of Alveolar-Capillary Diffusion after Inhalation of Endotoxin in Normal Subjects, 10.1378/chest.102.4.1095
  29. Doreswamy V., Peden D. B., Modulation of asthma by endotoxin : Modulation of asthma by endotoxin, 10.1111/j.1365-2222.2010.03628.x
  30. Rylander Ragnar, Endotoxin and occupational airway disease : , 10.1097/01.all.0000202356.83509.f7
  31. Osornio-Vargas Álvaro R., Bonner James C., Alfaro-Moreno Ernesto, Martínez Leticia, García-Cuellar Claudia, Rosales Sergio Ponce-de-León, Miranda Javier, Rosas Irma, Proinflammatory and Cytotoxic Effects of Mexico City Air Pollution Particulate Matter in Vitro Are Dependent on Particle Size and Composition, 10.1289/ehp.5913
  32. Duan W., So T., Croft M., Antagonism of Airway Tolerance by Endotoxin/Lipopolysaccharide through Promoting OX40L and Suppressing Antigen-Specific Foxp3+ T Regulatory Cells, 10.4049/jimmunol.181.12.8650
  33. Eisenbarth Stephanie C., Piggott Damani A., Huleatt James W., Visintin Irene, Herrick Christina A., Bottomly Kim, Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen, 10.1084/jem.20021340
  34. Barboza Renato, Câmara Niels Olsen Saraiva, Gomes Eliane, Sá-Nunes Anderson, Florsheim Esther, Mirotti Luciana, Labrada Alexis, Alcântara-Neves Neuza Maria, Russo Momtchilo, Endotoxin Exposure during Sensitization to Blomia tropicalis Allergens Shifts TH2 Immunity Towards a TH17-Mediated Airway Neutrophilic Inflammation: Role of TLR4 and TLR2, 10.1371/journal.pone.0067115
  35. Berger M., de Boer J. D., Bresser P., van der Poll T., Lutter R., Sterk P. J., van der Zee J. S., Lipopolysaccharide amplifies eosinophilic inflammation after segmental challenge with house dust mite in asthmatics, 10.1111/all.12544
  36. Casset Anne, Purohit Ashok, Birba Emile, Chenard Marie-Pierre, Uring Lambert Béatrice, Bahram Siamak, Meyer Pierre, Pauli Gabrielle, De Blay Frédéric, Bronchial Challenge Test in Asthmatics Sensitized to Mites: Role of Particle Size in Bronchial Response, 10.1089/jam.2007.0591
  37. Juarez Esmeralda, Nuñez Carlos, Sada Eduardo, Ellner Jerrold J, Schwander Stephan K, Torres Martha, Differential expression of Toll-like receptors on human alveolar macrophages and autologous peripheral monocytes, 10.1186/1465-9921-11-2
  38. Thorley Andrew J., Grandolfo Davide, Lim Eric, Goldstraw Peter, Young Alan, Tetley Teresa D., Innate Immune Responses to Bacterial Ligands in the Peripheral Human Lung – Role of Alveolar Epithelial TLR Expression and Signalling, 10.1371/journal.pone.0021827
  39. Singh Dave, Siew Leonard, Christensen Jared, Plumb Jonathan, Clarke Graham W., Greenaway Steve, Perros-Huguet Christelle, Clarke Nick, Kilty Iain, Tan Lisa, Oral and inhaled p38 MAPK inhibitors: effects on inhaled LPS challenge in healthy subjects, 10.1007/s00228-015-1920-1
  40. Leaker Brian R, Barnes Peter J, O’Connor Brian, Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist, 10.1186/1465-9921-14-137
  41. Gras Delphine, Chanez Pascal, Vachier Isabelle, Petit Aurélie, Bourdin Arnaud, Bronchial epithelium as a target for innovative treatments in asthma, 10.1016/j.pharmthera.2013.07.008
  42. Shirey Kari Ann, Lai Wendy, Scott Alison J., Lipsky Michael, Mistry Pragnesh, Pletneva Lioubov M., Karp Christopher L., McAlees Jaclyn, Gioannini Theresa L., Weiss Jerrold, Chen Wilbur H., Ernst Robert K., Rossignol Daniel P., Gusovsky Fabian, Blanco Jorge C. G., Vogel Stefanie N., The TLR4 antagonist Eritoran protects mice from lethal influenza infection, 10.1038/nature12118
  43. Savov J. D., Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide, 10.1152/ajplung.00014.2005