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Notch3 drives development and progression of cholangiocarcinoma.

Bibliographic reference Guest, Rachel V ; Boulter, Luke ; Dwyer, Benjamin J ; Kendall, Timothy J ; Man, Tak-Yung ; et. al. Notch3 drives development and progression of cholangiocarcinoma.. In: Proceedings of the National academy of sciences of the United States of America, Vol. 113, no.43, p. 12250-12255 (2016)
Permanent URL http://hdl.handle.net/2078.1/180106
  1. Kopan Raphael, Huppert Stacey S., Le Anh, Schroeter Eric H., Mumm Jeffrey S., Saxena Meera T., Milner Laurie A., 10.1038/35016111
  2. Zong Y., Panikkar A., Xu J., Antoniou A., Raynaud P., Lemaigre F., Stanger B. Z., Notch signaling controls liver development by regulating biliary differentiation, 10.1242/dev.029140
  3. Krebs Luke T., Xue Yingzi, Norton Christine R., Sundberg John P., Beatus Paul, Lendahl Urban, Joutel Anne, Gridley Thomas, Characterization ofNotch3-deficient mice: Normal embryonic development and absence of genetic interactions with aNotch1 mutation, 10.1002/gene.10241
  4. Khan Shahid A., Thomas Howard C., Toledano Mireille B., Cox I. Jane, Taylor-Robinson Simon D., p53 mutations in human cholangiocarcinoma: a review, 10.1111/j.1478-3231.2005.01106.x
  5. Guest R. V., Boulter L., Kendall T. J., Minnis-Lyons S. E., Walker R., Wigmore S. J., Sansom O. J., Forbes S. J., Cell Lineage Tracing Reveals a Biliary Origin of Intrahepatic Cholangiocarcinoma, 10.1158/0008-5472.can-13-1911
  6. Means Anna L., Xu Yanwen, Zhao Aizhen, Ray Kevin C., Gu Guoqiang, A CK19CreERTknockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs, 10.1002/dvg.20397
  7. Shimizu Yukihiro, Demetris Anthony J., Gollin Susanne M., Storto Patrick D., Bedford H. Melanic, Altarac Silvio, Iwatsuki Shunzaburo, Herberman Ronald B., Whiteside Theresa L., Two new human cholangiocarcinoma cell lines and their cytogenetics and responses to growth factors, hormones, cytokines or immunologic effector cells, 10.1002/ijc.2910520217
  8. Villanueva Augusto, Alsinet Clara, Yanger Kilangsungla, Hoshida Yujin, Zong Yiwei, Toffanin Sara, Rodriguez–Carunchio Leonardo, Solé Manel, Thung Swan, Stanger Ben Z., Llovet Josep M., Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice, 10.1053/j.gastro.2012.09.002
  9. Andersen Jesper B., Spee Bart, Blechacz Boris R., Avital Itzhak, Komuta Mina, Barbour Andrew, Conner Elizabeth A., Gillen Matthew C., Roskams Tania, Roberts Lewis R., Factor Valentina M., Thorgeirsson Snorri S., Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors, 10.1053/j.gastro.2011.12.005
  10. Huntzicker Erik G., Hötzel Kathy, Choy Lisa, Che Li, Ross Jed, Pau Gregoire, Sharma Neeraj, Siebel Christian W., Chen Xin, French Dorothy M., Differential effects of targeting Notch receptors in a mouse model of liver cancer, 10.1002/hep.27566
  11. Ahn Soomin, Hyeon Jiyeon, Park Cheol-Keun, Notchl and Notch4 are markers for poor prognosis of hepatocellular carcinoma, 10.1016/s1499-3872(13)60046-6
  12. Bellavia Diana, Campese Antonio F., Checquolo Saula, Balestri Anna, Biondi Andrea, Cazzaniga Giovanni, Lendahl Urban, Fehling Hans J., Hayday Adrian C., Frati Luigi, von Boehmer Harald, Gulino Alberto, Screpanti Isabella, Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis, 10.1073/pnas.062050599
  13. Boulter Luke, Govaere Olivier, Bird Tom G, Radulescu Sorina, Ramachandran Prakash, Pellicoro Antonella, Ridgway Rachel A, Seo Sang Soo, Spee Bart, Van Rooijen Nico, Sansom Owen J, Iredale John P, Lowell Sally, Roskams Tania, Forbes Stuart J, Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease, 10.1038/nm.2667
  14. van Es Johan H., van Gijn Marielle E., Riccio Orbicia, van den Born Maaike, Vooijs Marc, Begthel Harry, Cozijnsen Miranda, Robine Sylvie, Winton Doug J., Radtke Freddy, Clevers Hans, Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells, 10.1038/nature03659
  15. Ewald Florian, Grabinski Nicole, Grottke Astrid, Windhorst Sabine, Nörz Dominik, Carstensen Lisa, Staufer Katharina, Hofmann Bianca T., Diehl Frank, David Kerstin, Schumacher Udo, Nashan Björn, Jücker Manfred, Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma : Combined Targeting of AKT and mTOR for CCA, 10.1002/ijc.28214
  16. Ayaz Furkan, Osborne Barbara A., Non-Canonical Notch Signaling in Cancer and Immunity, 10.3389/fonc.2014.00345
  17. Vacca Alessandra, Felli Maria Pia, Palermo Rocco, Di Mario Giuseppina, Calce Angelica, Di Giovine Monica, Frati Luigi, Gulino Alberto, Screpanti Isabella, Notch3 and pre-TCR interaction unveils distinct NF-κB pathways in T-cell development and leukemia, 10.1038/sj.emboj.7600996
  18. Lee K.-S., Wu Z., Song Y., Mitra S. S., Feroze A. H., Cheshier S. H., Lu B., Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway, 10.1101/gad.225169.113
  19. Chen Xu, Stoeck Alexander, Lee Soo Jung, Shih Ie-Ming, Wang Michael M., Wang Tian-Li, Jagged1 expression regulated by Notch3 and Wnt/β-catenin signaling pathways in ovarian cancer, 10.18632/oncotarget.127
  20. Lu Wei-Yu, Bird Thomas G., Boulter Luke, Tsuchiya Atsunori, Cole Alicia M., Hay Trevor, Guest Rachel V., Wojtacha Davina, Man Tak Yung, Mackinnon Alison, Ridgway Rachel A., Kendall Timothy, Williams Michael J., Jamieson Thomas, Raven Alex, Hay David C., Iredale John P., Clarke Alan R., Sansom Owen J., Forbes Stuart J., Hepatic progenitor cells of biliary origin with liver repopulation capacity, 10.1038/ncb3203
  21. Ortica S., Tarantino N., Aulner N., Israel A., Gupta-Rossi N., The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors, 10.1096/fj.13-235903
  22. Mazur P. K., Einwachter H., Lee M., Sipos B., Nakhai H., Rad R., Zimber-Strobl U., Strobl L. J., Radtke F., Kloppel G., Schmid R. M., Siveke J. T., Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma, 10.1073/pnas.1002423107
  23. Font-Burgada Joan, Shalapour Shabnam, Ramaswamy Suvasini, Hsueh Brian, Rossell David, Umemura Atsushi, Taniguchi Koji, Nakagawa Hayato, Valasek Mark A., Ye Li, Kopp Janel L., Sander Maike, Carter Hannah, Deisseroth Karl, Verma Inder M., Karin Michael, Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer, 10.1016/j.cell.2015.07.026
  24. Fan Biao, Malato Yann, Calvisi Diego F., Naqvi Syed, Razumilava Nataliya, Ribback Silvia, Gores Gregory J., Dombrowski Frank, Evert Matthias, Chen Xin, Willenbring Holger, Cholangiocarcinomas can originate from hepatocytes in mice, 10.1172/jci63212
  25. Zender Steffen, Nickeleit Irina, Wuestefeld Torsten, Sörensen Inga, Dauch Daniel, Bozko Przemyslaw, El-Khatib Mona, Geffers Robert, Bektas Hueseyin, Manns Michael P., Gossler Achim, Wilkens Ludwig, Plentz Ruben, Zender Lars, Malek Nisar P., A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas, 10.1016/j.ccr.2013.04.019
  26. Tarlow Branden D., Pelz Carl, Naugler Willscott E., Wakefield Leslie, Wilson Elizabeth M., Finegold Milton J., Grompe Markus, Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes, 10.1016/j.stem.2014.09.008
  27. Yeh C.-N., Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma, 10.1093/carcin/bgh037