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Semi-parametric frailty model for clustered interval-censored data

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Cetinyürek, Aysun Lambert, Philippe [UCL]

The shared frailty model is a popular tool to analyze correlated right-censored time-to-event data. In the shared frailty model, the latent frailty is assumed to be shared by the members of a cluster and is assigned a parametric distribution, typically a gamma distribution due to its conjugacy. In the case of interval-censored time-to-event data, the inclusion of frailties results in complicated intractable likelihoods. Here, we propose a exible frailty model for analyzing such data by assuming a smooth semiparametric form for the conditional time-to-event distribution and a parametric or a exible form for the frailty distribution. The results of a simulation study suggest that the estimation of regression parameters is robust to misspeci cation of the frailty distribution (even when the frailty distribution is multimodal or skewed). Given su ciently large sample sizes and number of clusters, the exible approach produces smooth and accurate posterior estimates for the baseline survival function and for the frailty density, and can correctly detect and identify unusual frailty density forms. The methodology is illustrated using dental data from the Signal Tandmobiel® Study.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "Statistical Modelling : an international journal" - Vol. 16, no.5, p. 360-391 (2016)
Peer reviewed yes
Publisher Sage Publications India Pvt. Ltd. (New Delhi)
issn 1471-082X
e-issn 1477-0342
Publication status Publié
Affiliation UCL - SSH/LIDAM/ISBA - Institut de Statistique, Biostatistique et Sciences Actuarielles
Keywords Bayesian ; interval censoring ; P-splines ; shared frailty
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Bibliographic reference Cetinyürek, Aysun ; Lambert, Philippe. Semi-parametric frailty model for clustered interval-censored data. In: Statistical Modelling : an international journal, Vol. 16, no.5, p. 360-391 (2016)
Permanent URL http://hdl.handle.net/2078.1/177215