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P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization

Bibliographic reference Deiteren, Annemie ; van der Linden, Laura ; de Wit, Anouk ; Ceuleers, Hannah ; Buckinx, Roeland ; et. al. P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization. In: PLoS One, Vol. 10, no.4, p. e0123810 [1-17] (2015)
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  1. Vermeulen Wim, Neuroanatomy of lower gastrointestinal pain disorders, 10.3748/wjg.v20.i4.1005
  2. DE SCHEPPER H. U., DE MAN J. G., MOREELS T. G., PELCKMANS P. A., DE WINTER B. Y., Review article: gastrointestinal sensory and motor disturbances in inflammatory bowel disease - clinical relevance and pathophysiological mechanisms : REVIEW: IBD AND FUNCTIONAL DISORDERS, 10.1111/j.1365-2036.2008.03624.x
  3. Longstreth George F., Thompson W. Grant, Chey William D., Houghton Lesley A., Mearin Fermin, Spiller Robin C., Functional Bowel Disorders, 10.1053/j.gastro.2005.11.061
  4. Spiller Robin, Garsed Klara, Postinfectious Irritable Bowel Syndrome, 10.1053/j.gastro.2009.02.074
  5. Burnstock Geoffrey, Purine-mediated signalling in pain and visceral perception, 10.1016/s0165-6147(00)01643-6
  6. Ford Anthony P D W., Gever Joel R., Nunn Philip A., Zhong Yu, Cefalu Joseph S., Dillon Michael P., Cockayne Debra A., Purinoceptors as therapeutic targets for lower urinary tract dysfunction, 10.1038/sj.bjp.0706637
  7. Galligan James J, Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome, 10.1038/sj.bjp.0705761
  8. Yiangou Y., Facer P., Baecker P. A., Ford A. P., Knowles C. H., Chan C. L. H., Williams N. S., Anand P., ATP-gated ion channel P2X3is increased in human inflammatory bowel disease, 10.1046/j.1365-2982.2001.00276.x
  9. G Burnstock, 333 (2009)
  10. Cockayne Debra A., Dunn Philip M., Zhong Yu, Rong Weifang, Hamilton Sara G., Knight Gillian E., Ruan Huai-Zhen, Ma Bei, Yip Ping, Nunn Philip, McMahon Stephen B., Burnstock Geoffrey, Ford Anthony P. D. W., P2X2knockout mice and P2X2/P2X3double knockout mice reveal a role for the P2X2receptor subunit in mediating multiple sensory effects of ATP : Sensory deficits in P2X knockout mice, 10.1113/jphysiol.2005.088435
  11. Ford Anthony P., In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization, 10.1007/s11302-011-9271-6
  12. Robinson D. R., McNaughton P. A., Evans M. L., Hicks G. A., Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling, 10.1046/j.1365-2982.2003.00456.x
  13. rong w., keating c., sun b., dong l., grundy d., Purinergic contribution to small intestinal afferent hypersensitivity in a murine model of postinfectious bowel disease, 10.1111/j.1365-2982.2008.01259.x
  14. Shinoda Masamichi, Feng Bin, Gebhart G.F., Peripheral and Central P2X3 Receptor Contributions to Colon Mechanosensitivity and Hypersensitivity in the Mouse, 10.1053/j.gastro.2009.06.048
  15. Shinoda M., La J.-H., Bielefeldt K., Gebhart G. F., Altered Purinergic Signaling in Colorectal Dorsal Root Ganglion Neurons Contributes to Colorectal Hypersensitivity, 10.1152/jn.00560.2010
  16. Wynn Gregory, Rong Weifang, Xiang Zhenghua, Burnstock Geoffrey, Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum, 10.1016/j.gastro.2003.07.008
  17. Wynn G., Purinergic component of mechanosensory transduction is increased in a rat model of colitis, 10.1152/ajpgi.00020.2004
  18. Xu G-Y, Shenoy M, Winston J H, Mittal S, Pasricha P J, P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity, 10.1136/gut.2007.134221
  19. Honore Prisca, Mikusa Joseph, Bianchi Bruce, McDonald Heath, Cartmell Jayne, Faltynek Connie, Jarvis Michael F., TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics : , 10.1016/s0304-3959(01)00434-1
  20. Jarvis M. F., Burgard E. C., McGaraughty S., Honore P., Lynch K., Brennan T. J., Subieta A., van Biesen T., Cartmell J., Bianchi B., Niforatos W., Kage K., Yu H., Mikusa J., Wismer C. T., Zhu C. Z., Chu K., Lee C.-H., Stewart A. O., Polakowski J., Cox B. F., Kowaluk E., Williams M., Sullivan J., Faltynek C., A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat, 10.1073/pnas.252537299
  21. Deiteren Annemie, De Man Joris G, Ruyssers Nathalie E, Moreels Tom G, Pelckmans Paul A, De Winter Benedicte Y, Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity, 10.1136/gutjnl-2013-305870
  22. Vermeulen Wim, Joris G. De Man, Heiko U. De Schepper, Bult Hidde, Moreels Tom G., Pelckmans Paul A., Benedicte Y. De Winter, Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats, 10.1016/j.ejphar.2012.10.014
  23. W Vermeulen, Acta Gastroenterol Belg, 74, 304 (2011)
  24. JL Wallace, Am J Physiol, 258, G527 (1990)
  25. Ness T.J., Gebhart G.F., Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat, 10.1016/0006-8993(88)91555-7
  26. Deiteren Annemie, Vermeulen Wim, Moreels Tom G., Pelckmans Paul A., De Man Joris G., De Winter Benedicte Y., The effect of chemically induced colitis, psychological stress and their combination on visceral pain in female Wistar rats, 10.3109/10253890.2014.951034
  27. Abad Catalina, Juarranz Yasmina, Martinez Carmen, Arranz Alicia, Rosignoli Florencia, García-Gómez María, Leceta Javier, Gomariz Rosa P, cDNA Array Analysis of Cytokines, Chemokines, and Receptors Involved in the Development of TNBS-Induced Colitis: Homeostatic Role of VIP : , 10.1097/01.mib.0000171872.70738.58
  28. Sharp Caroline J, Reeve Alison J, Collins Sue D, Martindale Jo C, Summerfield Scott G, Sargent Becky S, Bate Simon T, Chessell Iain P, Investigation into the role of P2X3/P2X2/3 receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study : Investigation into the role of P2X3/P2X2/3 receptors, 10.1038/sj.bjp.0706790
  29. Wu Gang, Whiteside Garth T., Lee Gary, Nolan Scott, Niosi Mark, Pearson Michelle S., Ilyin Victor I., A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats, 10.1016/j.ejphar.2004.09.056
  30. Cavaliere F., Amadio S., Dinkel K., Reymann K. G., Volonte C., P2 Receptor Antagonist Trinitrophenyl-Adenosine-Triphosphate Protects Hippocampus from Oxygen and Glucose Deprivation Cell Death, 10.1124/jpet.106.119024
  31. Van Crombruggen K., Van Nassauw L., Timmermans J.-P., Lefebvre R.A., Inhibitory purinergic P2 receptor characterisation in rat distal colon, 10.1016/j.neuropharm.2007.05.010
  32. Bian X., Ren J., De Vries M., Schnegelsberg B., Cockayne D. A, Ford A. P D W, Galligan J. J, Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit, 10.1113/jphysiol.2003.044172
  33. Noma N., Shinoda M., Honda K., Kiyomoto M., Dezawa K., Nakaya Y., Komiyama O., Imamura Y., Iwata K., Interaction of IL-1β and P2X3 Receptor in Pathologic Masseter Muscle Pain, 10.1177/0022034513483770
  34. Ma Bei, Yu Li-hua, Fan Juan, Cong Binhai, He Ping, Ni Xin, Burnstock Geoffrey, Estrogen modulation of peripheral pain signal transduction: involvement of P2X3 receptors, 10.1007/s11302-010-9212-9
  35. Hsieh Yu-Lin, Chiang Hao, Lue June-Horng, Hsieh Sung-Tsang, P2X3-mediated peripheral sensitization of neuropathic pain in resiniferatoxin-induced neuropathy, 10.1016/j.expneurol.2012.02.013
  36. Cauwels A, Rogge E, Vandendriessche B, Shiva S, Brouckaert P, Extracellular ATP drives systemic inflammation, tissue damage and mortality, 10.1038/cddis.2014.70
  37. Wynn Gregory, Burnstock Geoffrey, Adenosine 5′-triphosphate and its relationship with other mediators that activate pelvic nerve afferent neurons in the rat colorectum, 10.1007/s11302-005-5305-2
  38. Volonté Cinzia, Burnstock Geoffrey, P2X3 receptor: a novel ‘CASKade’ of signaling?, 10.1111/jnc.12282
  39. Matricon J., Muller E., Accarie A., Meleine M., Etienne M., Voilley N., Busserolles J., Eschalier A., Lazdunski M., Bourdu S., Gelot A., Ardid D., Peripheral contribution of NGF and ASIC1a to colonic hypersensitivity in a rat model of irritable bowel syndrome, 10.1111/nmo.12199
  40. Jones R. C. W., The Mechanosensitivity of Mouse Colon Afferent Fibers and Their Sensitization by Inflammatory Mediators Require Transient Receptor Potential Vanilloid 1 and Acid-Sensing Ion Channel 3, 10.1523/jneurosci.0703-05.2005
  41. Yiangou Yiangos, Facer Paul, Smith Jacqueline A. M., Sangameswaran Lakshmi, Eglen Richard, Birch Rolfe, Knowles Charles, Williams Norman, Anand Praveen, Increased acid-sensing ion channel ASIC-3 in inflamed human intestine : , 10.1097/00042737-200108000-00003
  42. ME Kreis, Am J Physiol, 275, G675 (1998)