Accumulation of neurotoxic organochlorines and trace elements inbrain of female European eel (Anguilla anguilla)

Xenobiotics such as organochlorine compounds (OCs) and metals have been suggested to play a signif-icant role in the collapse of European eel stocks in the last decades. Several of these pollutants couldaffect functioning of the nervous system. Still, no information is so far available on levels of potentiallyneurotoxic pollutants in eel brain. In present study, carried out on female eels caught in Belgian rivers andcanals, we analyzed brain levels of potentially-neurotoxic trace elements (Ag, Al, As, Cd, Co, Cr, Cu, Fe, Hg,MeHg, Mn, Ni, Pb, Sn, Sb, Zn) and OCs (Polychlorinated biphenyls, PCBs; Hexachlorocyclohexanes, HCHs;Dichlorodiphenyltrichloroethane and its metabolites, DDTs). Data were compared to levels in liver andmuscle tissues. Eel brain contained very high amounts of OCs, superior to those found in the two other tis-sues. Interestingly, the relative abundance of PCB congeners markedly differed between tissues. In brain,a predominance of low chlorinated PCBs was noted, whereas highly chlorinated congeners prevailed inmuscle and liver. HCHs were particularly abundant in brain, which contains the highest amounts of -HCH and ϒ-HCH. p,p’-DDTs concentration was similar between brain and muscle (i.e., about twice that ofliver). A higher proportion of p,p’-DDT was noticed in brain. Except for Cr and inorganic Hg, all potentiallyneurotoxic metals accumulated in brain to levels equal to or lower than hepatic levels. Altogether, resultsindicate that eel brain is an important target for organic and, to a lesser extent, for inorganic neurotoxicpollutants.