Bosier, Barbara
[UCL]
Doyen, Pierre
[UCL]
Brolet, Amandine
[UCL]
Muccioli, Giulio
[UCL]
Ahmed, Eman
[UCL]
Desmet, Nathalie
[UCL]
Hermans, Emmanuel
[UCL]
Deumens, Ronald
[UCL]
Regulators of G protein signalling (RGS) are major determinants of metabotropic receptor activity, reducing the lifespan of the GTP-bound state of G proteins. Because the reduced potency of analgesic agents in neuropathic pain may reflect alterations in RGS, we assessed the effects of CCG 63802, a specific RGS4 inhibitor, on pain hypersensitivity and signalling through cannabinoid receptors, in a model of neuropathic pain.
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Bibliographic reference |
Bosier, Barbara ; Doyen, Pierre ; Brolet, Amandine ; Muccioli, Giulio ; Ahmed, Eman ; et. al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.. In: British Journal of Pharmacology, Vol. 172, no.22, p. 5333-5346 (2015) |
Permanent URL |
http://hdl.handle.net/2078.1/172491 |