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AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

Bibliographic reference Johanns, Manuel ; Lai, Y.-C. ; Hsu, M.-F. ; Jacobs, R. ; Vertommen, D. ; et. al. AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B. In: Nature Communications, Vol. 7, no.-, p. 10856 (2016)
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  1. Exton J. H., J. Biol. Chem., 246, 6166 (1971)
  2. Pilkis S., Schlumpf J., Pilkis J., Claus T.H., Regulation of phosphofructokinase activity by glucagon in isolated rat hepatocytes, 10.1016/0006-291x(79)91501-8
  3. Hue Louis, Felíu Juan Emilio, Hers Henri-Géry, Control of gluconeogenesis and of enzymes of glycogen metabolism in isolated rat hepatocytes. A parallel study of the effect of phenylephrine and of glucagon, 10.1042/bj1760791
  4. Sutherland E. W., Studies on the Mechanism of Hormone Action, 10.1126/science.177.4047.401
  5. Walsh D. A., Adv. Cyclic Nucleotide Res., 1, 33 (1972)
  6. Iynedjian P B, Auberger P, Guigoz Y, Le Cam A, Pretranslational regulation of tyrosine aminotransferase and phosphoenolpyruvate carboxykinase (GTP) synthesis by glucagon and dexamethasone in adult rat hepatocytes, 10.1042/bj2250077
  7. Hornbuckle L. A., Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ, 10.1152/ajpendo.00455.2003
  8. Claus Thomas H., Pilkis Simon J., Park Charles R., Stimulation by glucagon of the incorporation of U-14 C-labeled substrates into glucose by isolated hepatocytes from fed rats, 10.1016/0304-4165(75)90152-x
  9. D'Alessio D., The role of dysregulated glucagon secretion in type 2 diabetes, 10.1111/j.1463-1326.2011.01449.x
  10. Wollen Nigel, Bailey Clifford J., Inhibition of hepatic gluconeogenesis by metformin, 10.1016/0006-2952(88)90617-x
  11. Zhou Gaochao, Myers Robert, Li Ying, Chen Yuli, Shen Xiaolan, Fenyk-Melody Judy, Wu Margaret, Ventre John, Doebber Thomas, Fujii Nobuharu, Musi Nicolas, Hirshman Michael F., Goodyear Laurie J., Moller David E., Role of AMP-activated protein kinase in mechanism of metformin action, 10.1172/jci200113505
  12. Hawley S. A., Gadalla A. E., Olsen G. S., Hardie D. G., The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism, 10.2337/diabetes.51.8.2420
  13. Meng Shumei, Cao Jia, He Qiyi, Xiong Lishou, Chang Evan, Radovick Sally, Wondisford Fredric E., He Ling, Metformin Activates AMP-activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex, 10.1074/jbc.m114.604421
  14. Yu Bing, Pugazhenthi Subbiah, Khandelwal Ramji L., Effects of metformin on glucose and glucagon regulated gluconeogenesis in cultured normal and diabetic hepatocytes, 10.1016/0006-2952(94)90365-4
  15. Duca Frank A, Côté Clémence D, Rasmussen Brittany A, Zadeh-Tahmasebi Melika, Rutter Guy A, Filippi Beatrice M, Lam Tony K T, Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats, 10.1038/nm.3787
  16. Shaw R. J., The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin, 10.1126/science.1120781
  17. Foretz Marc, Hébrard Sophie, Leclerc Jocelyne, Zarrinpashneh Elham, Soty Maud, Mithieux Gilles, Sakamoto Kei, Andreelli Fabrizio, Viollet Benoit, Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state, 10.1172/jci40671
  18. Cao Jia, Meng Shumei, Chang Evan, Beckwith-Fickas Katherine, Xiong Lishou, Cole Robert N., Radovick Sally, Wondisford Fredric E., He Ling, Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK), 10.1074/jbc.m114.567271
  19. He Ling, Sabet Amin, Djedjos Stephen, Miller Ryan, Sun Xiaojian, Hussain Mehboob A., Radovick Sally, Wondisford Fredric E., Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein, 10.1016/j.cell.2009.03.016
  20. Miller Russell A., Chu Qingwei, Xie Jianxin, Foretz Marc, Viollet Benoit, Birnbaum Morris J., Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP, 10.1038/nature11808
  21. Madiraju Anila K., Erion Derek M., Rahimi Yasmeen, Zhang Xian-Man, Braddock Demetrios T., Albright Ronald A., Prigaro Brett J., Wood John L., Bhanot Sanjay, MacDonald Michael J., Jurczak Michael J., Camporez Joao-Paulo, Lee Hui-Young, Cline Gary W., Samuel Varman T., Kibbey Richard G., Shulman Gerald I., Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase, 10.1038/nature13270
  22. OWEN Mark R., DORAN Elena, HALESTRAP Andrew P., Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain, 10.1042/0264-6021:3480607
  23. Xiao B., Nat. Commun., 4, 3017 (2013)
  24. Lai Yu-Chiang, Kviklyte Samanta, Vertommen Didier, Lantier Louise, Foretz Marc, Viollet Benoît, Hallén Stefan, Rider Mark H., A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators, 10.1042/bj20131673
  25. Hayes J. S., Am. J. Physiol., 240, E340 (1981)
  26. Nichols M., EMBO J., 11, 3337 (1992)
  27. Heyworth C M, Wallace A V, Houslay M D, Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes, 10.1042/bj2140099
  28. Hermsdorf Thomas, Richter Wito, Dettmer Dietrich, Effects of Dexamethasone and Glucagon after Long-Term Exposure on Cyclic AMP Phosphodiesterase 4 in Cultured Rat Hepatocytes, 10.1016/s0898-6568(99)00039-x
  29. Hermsdorf Thomas, Dettmer Dietrich, Combined Effects of Insulin and Dexamethasone on Cyclic AMP Phosphodiesterase 3 and Glycogen Metabolism in Cultured Rat Hepatocytes, 10.1016/s0898-6568(98)00003-5
  30. Abdollahi Mohammad, Chan Tom S., Subrahmanyam Vangala, O'Brien Peter J., 10.1023/a:1025568714217
  31. MacKenzie Simon J, Baillie George S, McPhee Ian, MacKenzie Carolynn, Seamons Rachael, McSorley Theresa, Millen Jenni, Beard Matthew B, Heeke Gino, Houslay Miles D, Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1), 10.1038/sj.bjp.0704743
  32. RICHTER Wito, JIN S.-L. Catherine, CONTI Marco, Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue, 10.1042/bj20050030
  33. Sheppard Catherine L., Lee Louisa C.Y., Hill Elaine V., Henderson David J.P., Anthony Diana F., Houslay Daniel M., Yalla Krishna C., Cairns Lynne S., Dunlop Allan J., Baillie George S., Huston Elaine, Houslay Miles D., Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression, 10.1016/j.cellsig.2014.04.023
  34. Patel Kashyap, Foretz Marc, Marion Allison, Campbell David G., Gourlay Robert, Boudaba Nadia, Tournier Emilie, Titchenell Paul, Peggie Mark, Deak Maria, Wan Min, Kaestner Klaus H., Göransson Olga, Viollet Benoit, Gray Nathanael S., Birnbaum Morris J., Sutherland Calum, Sakamoto Kei, The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver, 10.1038/ncomms5535
  35. Itoh Yumi, Sanosaka Masato, Fuchino Hiroyuki, Yahara Yasuhito, Kumagai Ayako, Takemoto Daisaku, Kagawa Mai, Doi Junko, Ohta Miho, Tsumaki Noriyuki, Kawahara Nobuo, Takemori Hiroshi, Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes, 10.1074/jbc.m115.640821
  36. Kim Min-Jung, Park Su-Kyung, Lee Ji-Hyun, Jung Chang-Yun, Sung Dong Jun, Park Jae-Hyung, Yoon Young-Sil, Park Jinyoung, Park Keun-Gyu, Song Dae-Kyu, Cho Hana, Kim Seong-Tae, Koo Seung-Hoi, Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells, 10.2337/db14-1240
  37. Ducommun Serge, Deak Maria, Sumpton David, Ford Rebecca J., Núñez Galindo Antonio, Kussmann Martin, Viollet Benoit, Steinberg Gregory R., Foretz Marc, Dayon Loïc, Morrice Nicholas A., Sakamoto Kei, Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate, 10.1016/j.cellsig.2015.02.008
  38. Omori K., Kotera J., Overview of PDEs and Their Regulation, 10.1161/01.res.0000256354.95791.f1
  39. Pilkis S. J., J. Biol. Chem., 250, 6328 (1975)
  40. Tolbert M. E., J. Biol. Chem., 248, 5686 (1973)
  41. Garrison J. C., J. Biol. Chem., 248, 5333 (1973)
  42. Robles-Flores M, Allende G, Piña E, García-Sáinz J A, Cross-talk between glucagon- and adenosine-mediated signalling systems in rat hepatocytes: effects on cyclic AMP-phosphodiesterase activity, 10.1042/bj3120763
  43. Jin S.- L. C., Conti M., Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-  responses, 10.1073/pnas.122041599
  44. Leroy Jérôme, Richter Wito, Mika Delphine, Castro Liliana R.V., Abi-Gerges Aniella, Xie Moses, Scheitrum Colleen, Lefebvre Florence, Schittl Julia, Mateo Philippe, Westenbroek Ruth, Catterall William A., Charpentier Flavien, Conti Marco, Fischmeister Rodolphe, Vandecasteele Grégoire, Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice, 10.1172/jci44747
  45. Zhang Ren, Maratos-Flier Eleftheria, Flier Jeffrey S., Reduced Adiposity and High-Fat Diet-Induced Adipose Inflammation in Mice Deficient for Phosphodiesterase 4B, 10.1210/en.2009-0108
  46. Hue Louis, Rider Mark H., The AMP-activated protein kinase: more than an energy sensor, 10.1042/bse0430121
  47. Burgess Shawn C., Iizuka Katsumi, Jeoung Nam Ho, Harris Robert A., Kashiwaya Yoshihiro, Veech Richard L., Kitazume Tatsuya, Uyeda Kosaku, Carbohydrate-response Element-binding Protein Deletion Alters Substrate Utilization Producing an Energy-deficient Liver, 10.1074/jbc.m706540200
  48. Stoll B, Gerok W, Lang F, Häussinger D, Liver cell volume and protein synthesis, 10.1042/bj2870217
  49. Cusi K., Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus, 10.1210/jc.81.11.4059
  50. van Staveren W. C. G., Solis D. W., Delys L., Venet D., Cappello M., Andry G., Dumont J. E., Libert F., Detours V., Maenhaut C., From The Cover: Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis, 10.1073/pnas.0507354102
  51. Bultot Laurent, Guigas Bruno, Von Wilamowitz-Moellendorff Alexander, Maisin Liliane, Vertommen Didier, Hussain Nusrat, Beullens Monique, Guinovart Joan J., Foretz Marc, Viollet Benoît, Sakamoto Kei, Hue Louis, Rider Mark H., AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase, 10.1042/bj20112026
  52. Guigas B., Bertrand L., Taleux N., Foretz M., Wiernsperger N., Vertommen D., Andreelli F., Viollet B., Hue L., 5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation, 10.2337/diabetes.55.04.06.db05-1178
  53. Brooker G., Adv. Cyclic Nucleotide Res., 10, 1 (1979)
  54. Glass D.B., Masaracchia R.A., Feramisco J.R., Kemp B.E., Isolation of phosphorylated peptides and proteins on ion exchange papers, 10.1016/0003-2697(78)90707-8
  55. Roskoski Robert, [1] Assays of protein kinase, Methods in Enzymology (1983) ISBN:9780121819996 p.3-6, 10.1016/0076-6879(83)99034-1
  56. Hue L, Bontemps F, Hers H, The effects of glucose and of potassium ions on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations, 10.1042/bj1520105
  57. ERNEUX Christophe, COUCHIE Dominique, DUMONT Jacques E., Characterization of Horse Thyroid Cyclic Nucleotide Phosphodiesterases, 10.1111/j.1432-1033.1980.tb04428.x
  58. Plaideau Catheline, Lai Yu-Chiang, Kviklyte Samanta, Zanou Nadège, Löfgren Lars, Andersén Harriet, Vertommen Didier, Gailly Philippe, Hue Louis, Bohlooly-Y Mohammad, Hallén Stefan, Rider Mark H., Effects of Pharmacological AMP Deaminase Inhibition and Ampd1 Deletion on Nucleotide Levels and AMPK Activation in Contracting Skeletal Muscle, 10.1016/j.chembiol.2014.09.013
  59. Lee Ji Hyun, Richter Wito, Namkung Wan, Kim Kyung Hwan, Kim Eunjoon, Conti Marco, Lee Min Goo, Dynamic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by Competitive Interactions of Molecular Adaptors, 10.1074/jbc.m610857200
  60. Vertommen Didier, Rider Mark, Ni Youping, Waelkens Etienne, Merlevede Wilfried, Vandenheede Jackie R., Van Lint Johan, Regulation of Protein Kinase D by Multisite Phosphorylation : IDENTIFICATION OF PHOSPHORYLATION SITES BY MASS SPECTROMETRY AND CHARACTERIZATION BY SITE-DIRECTED MUTAGENESIS, 10.1074/jbc.m001357200