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Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.

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Wang, Wei [UCL] Jossin, Yves [UCL] Chai, Guoliang [UCL] Lien, Wen-Hui [UCL] Tissir, Fadel [UCL] Goffinet, André [UCL]

Sequential generation of neurons and glial cells during development is critical for the wiring and function of the cerebral cortex. This process requires accurate coordination of neural progenitor cell (NPC) fate decisions, by NPC-autonomous mechanisms as well as by negative feedback from neurons. Here, we show that neurogenesis is protracted and gliogenesis decreased in mice with mutations of genes Celsr3 and Fzd3. This phenotype is not due to gene inactivation in progenitors, but rather in immature cortical neurons. Mutant neurons are unable to upregulate expression of Jag1 in response to cortical Wnt7, resulting in blunted activation of Notch signalling in NPC. Thus, Celsr3 and Fzd3 enable immature neurons to respond to Wnt7, upregulate Jag1 and thereby facilitate feedback signals that tune the timing of NPC fate decisions via Notch activation.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2016
Language Anglais
Journal information "Nature Communications" - Vol. 7, p. 10936 (2016)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
e-issn 2041-1723
Publication status Publié
Affiliation UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
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Bibliographic reference Wang, Wei ; Jossin, Yves ; Chai, Guoliang ; Lien, Wen-Hui ; Tissir, Fadel ; et. al. Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.. In: Nature Communications, Vol. 7, p. 10936 (2016)
Permanent URL http://hdl.handle.net/2078.1/172409