User menu

Aging Reduces the Activation of the mTORC1 Pathway after Resistance Exercise and Protein Intake in Human Skeletal Muscle: Potential Role of REDD1 and Impaired Anabolic Sensitivity.

Bibliographic reference Francaux, Marc ; Demeulder, Bénédicte ; Naslain, Damien ; Fortin, Raphaël ; Lutz, Olivier ; et. al. Aging Reduces the Activation of the mTORC1 Pathway after Resistance Exercise and Protein Intake in Human Skeletal Muscle: Potential Role of REDD1 and Impaired Anabolic Sensitivity.. In: Nutrients, Vol. 8, no. 1, p. E47 [1-16] (2016)
Permanent URL
  1. Morley John E., Baumgartner Richard N., Roubenoff Ronenn, Mayer Jean, Nair K.Sreekumaran, Sarcopenia, 10.1067/mlc.2001.113504
  2. Morley John E., Anker Stefan D., von Haehling Stephan, Prevalence, incidence, and clinical impact of sarcopenia: facts, numbers, and epidemiology-update 2014, 10.1007/s13539-014-0161-y
  3. Breen, Br. J. Clin. Pharmacol., 75, 708 (2013)
  4. Kumar Vinod, Selby Anna, Rankin Debbie, Patel Rekha, Atherton Philip, Hildebrandt Wulf, Williams John, Smith Kenneth, Seynnes Olivier, Hiscock Natalie, Rennie Michael J., Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men : Age-related effects of exercise on muscle anabolism, 10.1113/jphysiol.2008.164483
  5. Moore D. R., Churchward-Venne T. A., Witard O., Breen L., Burd N. A., Tipton K. D., Phillips S. M., Protein Ingestion to Stimulate Myofibrillar Protein Synthesis Requires Greater Relative Protein Intakes in Healthy Older Versus Younger Men, 10.1093/gerona/glu103
  6. Rennie, Ann. Transplant., 10, 31 (2005)
  7. Drummond Micah J., Marcus Robin L., LaStayo Paul C., Targeting Anabolic Impairment in Response to Resistance Exercise in Older Adults with Mobility Impairments: Potential Mechanisms and Rehabilitation Approaches, 10.1155/2012/486930
  8. Rennie M. J., Selby A., Atherton P., Smith K., Kumar V., Glover E. L., Philips S. M., Facts, noise and wishful thinking: muscle protein turnover in aging and human disuse atrophy, 10.1111/j.1600-0838.2009.00967.x
  9. Volpi E., The Response of Muscle Protein Anabolism to Combined Hyperaminoacidemia and Glucose-Induced Hyperinsulinemia Is Impaired in the Elderly, 10.1210/jc.85.12.4481
  10. Katsanos, Am. J. Clin. Nutr., 82, 1065 (2005)
  11. Cuthbertson D., Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle, 10.1096/fj.04-2640fje
  12. Fry Christopher S, Drummond Micah J, Glynn Erin L, Dickinson Jared M, Gundermann David M, Timmerman Kyle L, Walker Dillon K, Dhanani Shaheen, Volpi Elena, Rasmussen Blake B, Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis, 10.1186/2044-5040-1-11
  13. Dunlop E.A., Tee A.R., Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms, 10.1016/j.cellsig.2009.01.012
  14. Guillet C., Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans, 10.1096/fj.03-1341fje
  15. Drummond M. J., Dreyer H. C., Pennings B., Fry C. S., Dhanani S., Dillon E. L., Sheffield-Moore M., Volpi E., Rasmussen B. B., Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging, 10.1152/japplphysiol.00021.2008
  16. Dreyer Hans C., Fujita Satoshi, Cadenas Jerson G., Chinkes David L., Volpi Elena, Rasmussen Blake B., Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle : AMPK, muscle protein synthesis and resistance exercise, 10.1113/jphysiol.2006.113175
  17. Greig C.A., Gray C., Rankin D., Young A., Mann V., Noble B., Atherton P.J., Blunting of adaptive responses to resistance exercise training in women over 75y, 10.1016/j.exger.2011.07.010
  18. Chevalier Stéphanie, Goulet Eric D.B., Burgos Sergio A., Wykes Linda J., Morais José A., Protein Anabolic Responses to a Fed Steady State in Healthy Aging, 10.1093/gerona/glr036
  19. Pennings B., Koopman R., Beelen M., Senden J. M., Saris W. H., van Loon L. J., Exercising before protein intake allows for greater use of dietary protein-derived amino acids for de novo muscle protein synthesis in both young and elderly men, 10.3945/ajcn.2010.29649
  20. Symonsi T. B., Sheffield-Moore M., Mamerow M. M., Wolfe R. R., Paddon-Jones Douglas, The anabolic response to resistance exercise and a protein-rich meal is not diminished by age, 10.1007/s12603-010-0319-z
  21. Raue U., Slivka D., Jemiolo B., Hollon C., Trappe S., Proteolytic Gene Expression Differs At Rest and After Resistance Exercise Between Young and Old Women, 10.1093/gerona/62.12.1407
  22. Fry C. S., Drummond M. J., Glynn E. L., Dickinson J. M., Gundermann D. M., Timmerman K. L., Walker D. K., Volpi E., Rasmussen B. B., Skeletal Muscle Autophagy and Protein Breakdown Following Resistance Exercise are Similar in Younger and Older Adults, 10.1093/gerona/gls209
  23. Van Thienen R., D'Hulst G., Deldicque L., Hespel P., Biochemical artifacts in experiments involving repeated biopsies in the same muscle, 10.14814/phy2.286
  24. Vandesompele Jo, De Preter Katleen, Pattyn Filip, Poppe Bruce, Van Roy Nadine, De Paepe Anne, Speleman Frank, 10.1186/gb-2002-3-7-research0034
  25. Haar Emilie Vander, Lee Seong-il, Bandhakavi Sricharan, Griffin Timothy J., Kim Do-Hyung, Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40, 10.1038/ncb1547
  26. Reynolds Thomas H., Bodine Sue C., Lawrence John C., Control of Ser2448Phosphorylation in the Mammalian Target of Rapamycin by Insulin and Skeletal Muscle Load, 10.1074/jbc.m201142200
  27. Foster Kathryn G., Fingar Diane C., Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony, 10.1074/jbc.r109.094003
  28. Kimball Scot R., Jefferson Leonard S., Control of protein synthesis by amino acid availability : , 10.1097/00075197-200201000-00012
  29. Ma Xiaoju Max, Blenis John, Molecular mechanisms of mTOR-mediated translational control, 10.1038/nrm2672
  30. Jang Taichang, Calaoagan Joy M., Kwon Eunice, Samuelsson Steven, Recht Lawrence, Laderoute Keith R., 5′-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat, 10.1002/ijc.25558
  31. Barth Sandra, Glick Danielle, Macleod Kay F, Autophagy: assays and artifacts, 10.1002/path.2694
  32. Sandri Marco, Autophagy in skeletal muscle, 10.1016/j.febslet.2010.01.056
  33. Bodine S. C., Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy, 10.1126/science.1065874
  34. Di Giulio, J. Biol. Regul. Homeost. Agents, 23, 55 (2009)
  35. Kiskini Alexandra, Hamer Henrike M., Wall Benjamin T., Groen Bart B. L., de Lange Anneke, Bakker Jaap A., Senden Joan M. G., Verdijk Lex B., van Loon Luc J. C., The muscle protein synthetic response to the combined ingestion of protein and carbohydrate is not impaired in healthy older men, 10.1007/s11357-013-9522-2
  36. Boirie, Am. J. Clin. Nutr., 65, 489 (1997)
  37. Rasmussen B. B., Insulin resistance of muscle protein metabolism in aging, 10.1096/fj.05-4607fje
  38. Dickinson Jared M., Drummond Micah J., Coben Jennifer R., Volpi Elena, Rasmussen Blake B., Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise, 10.1016/j.clnu.2012.07.009
  39. Mayhew D. L., Kim J.-s., Cross J. M., Ferrando A. A., Bamman M. M., Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans, 10.1152/japplphysiol.91234.2008
  40. Markofski Melissa M., Dickinson Jared M., Drummond Micah J., Fry Christopher S., Fujita Satoshi, Gundermann David M., Glynn Erin L., Jennings Kristofer, Paddon-Jones Douglas, Reidy Paul T., Sheffield-Moore Melinda, Timmerman Kyle L., Rasmussen Blake B., Volpi Elena, Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women, 10.1016/j.exger.2015.02.015
  41. Farnfield Michelle M., Breen Leigh, Carey Kate A., Garnham Andrew, Cameron-Smith David, Activation of mTOR signalling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion, 10.1139/h11-132
  42. Wiza C., Nascimento E. B. M., Ouwens D. M., Role of PRAS40 in Akt and mTOR signaling in health and disease, 10.1152/ajpendo.00660.2011
  43. Zhang Fengxue, Beharry Zanna M., Harris Thurl E., Lilly Michael B., Smith Charles D., Mahajan Sandeep, Kraft Andrew S., PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells, 10.4161/cbt.8.9.8210
  44. Frey John W., Jacobs Brittany L., Goodman Craig A., Hornberger Troy A., A role for Raptor phosphorylation in the mechanical activation of mTOR signaling, 10.1016/j.cellsig.2013.11.009
  45. Gwinn Dana M., Shackelford David B., Egan Daniel F., Mihaylova Maria M., Mery Annabelle, Vasquez Debbie S., Turk Benjamin E., Shaw Reuben J., AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint, 10.1016/j.molcel.2008.03.003
  46. Sengupta Shomit, Peterson Timothy R., Sabatini David M., Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress, 10.1016/j.molcel.2010.09.026
  47. Schwarzer Rolf, Tondera Daniel, Arnold Wolfgang, Giese Klaus, Klippel Anke, Kaufmann Jörg, REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase, 10.1038/sj.onc.1208236
  48. Frost Robert A., Huber Danuta, Pruznak Anne, Lang Charles H., Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes, 10.1002/jcb.22349
  49. Appuhamy J. A. D. R. N., Knoebel N. A., Nayananjalie W. A. D., Escobar J., Hanigan M. D., Isoleucine and Leucine Independently Regulate mTOR Signaling and Protein Synthesis in MAC-T Cells and Bovine Mammary Tissue Slices, 10.3945/jn.111.152595
  50. KAASTRA BRECHJE, MANDERS RALPH J. F., VAN BREDA ERIC, KIES ARIE, JEUKENDRUP ASKER E., KEIZER HANS A., KUIPERS HARM, VAN LOON LUC J. C., Effects of Increasing Insulin Secretion on Acute Postexercise Blood Glucose Disposal : , 10.1249/
  51. Williamson David L., Dungan Cory M., Mahmoud Abeer M., Mey Jacob T., Blackburn Brian K., Haus Jacob M., Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics, 10.1152/ajpregu.00285.2015
  52. Rennie Michael J., Anabolic resistance: the effects of aging, sexual dimorphism, and immobilization on human muscle protein turnoverThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process., 10.1139/h09-012
  53. Klionsky Daniel J., Autophagy revisited: A conversation with Christian de Duve, 10.4161/auto.6398
  54. Smith Gordon I., Atherton Philip, Villareal Dennis T., Frimel Tiffany N., Rankin Debbie, Rennie Michael J., Mittendorfer Bettina, Differences in Muscle Protein Synthesis and Anabolic Signaling in the Postabsorptive State and in Response to Food in 65–80 Year Old Men and Women, 10.1371/journal.pone.0001875
  55. Yarasheski, Am. J. Physiol., 265, E210 (1993)