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Contributions of growth hormone receptor and post-receptor defects to GH resistance in malnutrition

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Thissen, Jean-Paul [UCL] Maiter, Dominique [UCL]

Malnutrition results in poor growth and is associated with resistance to growth hormone (GH) action. The mechanisms involved in the GH resistance depend on the severity and the timing of the nutritional insult. Stringent dietary restrictions such as fasting may produce GH resistance by reducing the number of GH receptors. Less severe nutritional deprivation such a short-term protein restriction may cause GH insensitivity mainly through postreceptor mechanisms.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 1991
Language Anglais
Journal information "Trends in Endocrinology and Metabolism" - Vol. 2, no.0, p. 92-97 (1991)
Peer reviewed yes
Publisher Elsevier Ltd. * Trends Journals ((United Kingdom) Oxford)
issn 1043-2760
e-issn 1879-3061
Publication status Publié
Affiliations UCL - SSS/IREC/EDIN-Pôle d'endocrinologie, diabète et nutrition
UCL - (SLuc) Service d'endocrinologie et de nutrition
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Bibliographic reference Thissen, Jean-Paul ; Maiter, Dominique ; et. al. Contributions of growth hormone receptor and post-receptor defects to GH resistance in malnutrition. In: Trends in Endocrinology and Metabolism, Vol. 2, no.0, p. 92-97 (1991)
Permanent URL http://hdl.handle.net/2078.1/171619