User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Objective and self-reported cognitive dysfunction in breast cancer women treated with chemotherapy: a prospective study.

Primary tabs

Biglia, N Bounous, V E Malabaila, A Palmisano, D Torta, Diana [UCL] Torta, R

The objective of this study is to investigate if changes in cognitive functions can be recognised in patients undergoing chemotherapy for breast cancer. Forty women with breast cancer and without depression underwent cognitive evaluation before and after 6 months of chemotherapy; emotional evaluation was performed before and after 1, 3 and 6 months of chemotherapy. Self-reported cognitive deficit evaluation was included. Global cognitive functioning before starting chemotherapy was good. After 6 months of treatment there was a significant decline in some cognitive functions, particularly involving the attention subdomain. Objective cognitive deficit resulted independent from the emotional status. On the contrary, self-perceived mental dysfunction was unrelated to the objective cognitive decline, but it was associated with depression and anxiety. Breast cancer chemotherapy can induce domain-specific cognitive dysfunction. Patients' self-perception of mental decline is unrelated to objective cognitive deficit. Breast cancer patients negatively judge their cognitive performances if they have a negative emotional functioning.

Document type Article de périodique (Journal article)
Publication date 2012
Language Anglais
Journal information "European journal of cancer care" - Vol. 21, no.4, p. 485-492 (2012)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. (Chichester)
e-issn 1365-2354
Publication status Publié
Affiliation University of Turin - Department of Psychology
MESH Subject Adult ; Neuropsychological Tests ; Prospective Studies ; Aged ; Antineoplastic Combined Chemotherapy Protocols ; Breast Neoplasms ; Cognition ; Cognition Disorders ; Female ; Humans ; Middle Aged
Links
  1. Ahles T. A., Neuropsychologic Impact of Standard-Dose Systemic Chemotherapy in Long-Term Survivors of Breast Cancer and Lymphoma, 10.1200/jco.20.2.485
  2. Ahles Tim A., Saykin Andrew J., Candidate mechanisms for chemotherapy-induced cognitive changes, 10.1038/nrc2073
  3. Ahles Tim A., Saykin Andrew J., McDonald Brenna C., Furstenberg Charlotte T., Cole Bernard F., Hanscom Brett S., Mulrooney Tamsin J., Schwartz Gary N., Kaufman Peter A., Cognitive function in breast cancer patients prior to adjuvant treatment, 10.1007/s10549-007-9686-5
  4. Anderson-Hanley, Journal of Clinical Oncology, 20, 485 (2003)
  5. Barden, Journal of Psychiatry and Neuroscience, 29, 185 (2004)
  6. Bender Catherine M., Sereika Susan M., Berga Sarah L., Vogel Victor G., Brufsky Adam M., Paraska Karen K., Ryan Christopher M., Cognitive impairment associated with adjuvant therapy in breast cancer, 10.1002/pon.964
  7. de Jong N., Candel M. J. J. M., Schouten H. C., Huijer Abu-Saad H., Courtens A. M., Course of mental fatigue and motivation in breast cancer patients receiving adjuvant chemotherapy, 10.1093/annonc/mdi095
  8. Earnheart J. C., Schweizer C., Crestani F., Iwasato T., Itohara S., Mohler H., Luscher B., GABAergic Control of Adult Hippocampal Neurogenesis in Relation to Behavior Indicative of Trait Anxiety and Depression States, 10.1523/jneurosci.3609-06.2007
  9. Falleti Marina G., Sanfilippo Antonietta, Maruff Paul, Weih LeAnn, Phillips Kelly-Anne, The nature and severity of cognitive impairment associated with adjuvant chemotherapy in women with breast cancer: A meta-analysis of the current literature, 10.1016/j.bandc.2005.05.001
  10. Fayers, EORTC QLQ-C30 Scoring Manual, 2nd edn: EORTC Quality of Life Study Group (1999)
  11. Folstein Marshal F., Folstein Susan E., McHugh Paul R., “Mini-mental state”, 10.1016/0022-3956(75)90026-6
  12. Grassi Luigi, Buda Patrizia, Cavana Laura, Annunziata Maria Antonietta, Torta Riccardo, Varetto Antonella, Styles of coping with cancer: The Italian version of the Mini-Mental Adjustment to Cancer (Mini-MAC) scale, 10.1002/pon.826
  13. Hashimoto Kenji, Shimizu Eiji, Iyo Masaomi, Critical role of brain-derived neurotrophic factor in mood disorders, 10.1016/j.brainresrev.2004.02.003
  14. Hermelink Kerstin, Untch Michael, Lux Michael P., Kreienberg Rolf, Beck Thomas, Bauerfeind Ingo, Münzel Karin, Cognitive function during neoadjuvant chemotherapy for breast cancer : Results of a prospective, multicenter, longitudinal study, 10.1002/cncr.22610
  15. Hermelink Kerstin, Küchenhoff Helmut, Untch Michael, Bauerfeind Ingo, Lux Michael Patrick, Bühner Markus, Manitz Juliane, Fensterer Veronika, Münzel Karin, Two different sides of ‘chemobrain’: determinants and nondeterminants of self-perceived cognitive dysfunction in a prospective, randomized, multicenter study, 10.1002/pon.1695
  16. Hurria Arti, Somlo George, Ahles Tim, Renaming “Chemobrain”, 10.1080/07357900701506672
  17. Jansen Catherine E., Miaskowski Christine, Dodd Marylin, Dowling Glenna, Kramer Joel, A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function, 10.1002/cncr.21469
  18. Jenkins V, Shilling V, Deutsch G, Bloomfield D, Morris R, Allan S, Bishop H, Hodson N, Mitra S, Sadler G, Shah E, Stein R, Whitehead S, Winstanley J, A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer, 10.1038/sj.bjc.6603029
  19. Karnofsky David A., Abelmann Walter H., Craver Lloyd F., Burchenal Joseph H., The use of the nitrogen mustards in the palliative treatment of carcinoma.With particular reference to bronchogenic carcinoma, 10.1002/1097-0142(194811)1:4<634::aid-cncr2820010410>3.0.co;2-l
  20. Meeter Martijn, Talamini Lucia, Schmitt Jeroen A J, Riedel Wim J, Effects of 5-HT on Memory and the Hippocampus: Model and Data, 10.1038/sj.npp.1300869
  21. Montgomery S. A., Asberg M., A new depression scale designed to be sensitive to change, 10.1192/bjp.134.4.382
  22. Pardo José V., Pardo Patricia J., Humes Steven W., I. Posner Michael, Neurocognitive dysfunction in antidepressant-free, non-elderly patients with unipolar depression: Alerting and covert orienting of visuospatial attention, 10.1016/j.jad.2005.12.037
  23. Pullens Marleen J.J., De Vries Jolanda, Roukema Jan A., Subjective cognitive dysfunction in breast cancer patients: a systematic review, 10.1002/pon.1673
  24. Raffa R. B., Duong P. V., Finney J., Garber D. A., Lam L. M., Mathew S. S., Patel N. N., Plaskett K. C., Shah M., Jen Weng H.-F., Is 'chemo-fog'/'chemo-brain' caused by cancer chemotherapy?, 10.1111/j.1365-2710.2006.00726.x
  25. Raven, Standard Progressive Matrices: Sets A, B, C and D (1938)
  26. Reitan Ralph M., Validity of the Trail Making Test as an Indicator of Organic Brain Damage, 10.2466/pms.1958.8.3.271
  27. Sartori, Giornale dell'Ordine degli Psicologi, 4, 1 (1997)
  28. Schagen Sanne B., van Dam Frits S. A. M., Muller Martin J., Boogerd Willem, Lindeboom Jaap, Bruning Peter F., Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma, 10.1002/(sici)1097-0142(19990201)85:3<640::aid-cncr14>3.0.co;2-g
  29. Schagen Sanne B., Muller Martin J., Boogerd Willem, Mellenbergh Gideon J., van Dam Frits S. A. M., Change in Cognitive Function After Chemotherapy: a Prospective Longitudinal Study in Breast Cancer Patients, 10.1093/jnci/djj470
  30. Schiepers Olga J.G., Wichers Marieke C., Maes Michael, Cytokines and major depression, 10.1016/j.pnpbp.2004.11.003
  31. Shilling Val, Jenkins Valerie, Self-reported cognitive problems in women receiving adjuvant therapy for breast cancer, 10.1016/j.ejon.2006.02.005
  32. Spinnler, Italian Journal of Neurological Sciences, 6, 47 (1989)
  33. Stewart Angela, Bielajew Catherine, Collins Barbara, Parkinson Matthew, Tomiak Eva, A Meta-Analysis of the Neuropsychological Effects of Adjuvant Chemotherapy Treatment in Women Treated for Breast Cancer, 10.1080/138540491005875
  34. Stewart Angela, Collins Barbara, Mackenzie Joyce, Tomiak Eva, Verma Shailendra, Bielajew Catherine, The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study, 10.1002/pon.1210
  35. Torta, Psycho-Oncology, 15, 2 (2006)
  36. Valentine Alan D., Meyers Christina A., Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients, 10.1002/1097-0142(20010915)92:6+<1694::aid-cncr1499>3.0.co;2-s
  37. van Dam Frits S. A. M., Boogerd Willem, Schagen Sanne B., Muller Martin J., Droogleever Fortuyn Maria E., Wall Elsken v.d., Rodenhuis Sjoerd, Impairment of Cognitive Function in Women Receiving Adjuvant Treatment for High-Risk Breast Cancer: High-Dose Versus Standard-Dose Chemotherapy, 10.1093/jnci/90.3.210
  38. Vardy Janette, Rourke Sean, Tannock Ian F., Evaluation of Cognitive Function Associated With Chemotherapy: A Review of Published Studies and Recommendations for Future Research, 10.1200/jco.2006.08.1604
  39. Wagner, Annals of Behavioral Medicine, 27, S10 (2004)
  40. Wefel Jeffrey S., Lenzi Renato, Theriault Richard L., Davis Robert N., Meyers Christina A., The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma : Results of a prospective, randomized, longitudinal trial, 10.1002/cncr.20272
  41. Wefel Jeffrey S., Saleeba Angele K., Buzdar Aman U., Meyers Christina A., Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer, 10.1002/cncr.25098
  42. Wieneke Mary H., Dienst Evelyn R., Neuropsychological assessment of cognitive functioning following chemotherapy for breast cancer, 10.1002/pon.2960040108
  43. Zigmond A. S., Snaith R. P., The Hospital Anxiety and Depression Scale, 10.1111/j.1600-0447.1983.tb09716.x
Bibliographic reference Biglia, N ; Bounous, V E ; Malabaila, A ; Palmisano, D ; Torta, Diana ; et. al. Objective and self-reported cognitive dysfunction in breast cancer women treated with chemotherapy: a prospective study.. In: European journal of cancer care, Vol. 21, no.4, p. 485-492 (2012)
Permanent URL http://hdl.handle.net/2078/170191