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Functional anatomy of cortical areas characterized by Von Economo neurons.

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Cauda, Franco Torta, Diana [UCL] Sacco, Katiuscia D'Agata, Federico Geda, Elisabetta Vercelli, Alessandro

Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. To investigate the role of VENs in the active human brain, we have explored the functional connectivity of brain areas containing VENs by analyzing resting state functional connectivity (rsFC) in 20 healthy volunteers. Our results show that cortical areas containing VENs form a network of frontoparietal functional connectivity. With the use of fuzzy clustering techniques, we find that this network comprises four sub-networks: the first network cluster resembles a "saliency detection" attentional network, which includes superior frontal cortex (Brodmann's Area, BA 10), inferior parietal lobe, anterior insula, and dorsal anterior cingulate cortex; the second cluster, part of a "sensory-motor network", comprises the superior temporal, precentral and postcentral areas; the third cluster consists of frontal ventromedial and ventrodorsal areas constituted by parts of the "anterior default mode network"; and the fourth cluster encompasses dorsal anterior cingulate cortex, dorsomedial prefrontal, and superior frontal (BA 10) areas, resembling the anterior part of the "dorsal attentional network". Thus, the network that emerges from analyzing functional connectivity among areas that are known to contain VENs is primarily involved in functions of saliency detection and self-regulation. In addition, parts of this network constitute sub-networks that partially overlap with the default mode, the sensory-motor and the dorsal attentional networks.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2013
Language Anglais
Journal information "Brain Structure and Function" - Vol. 218, no.1, p. 1-20 (2012)
Peer reviewed yes
Publisher Springer (Heidelberg)
issn 1863-2653
e-issn 1863-2661
Publication status Publié
Affiliations University of Turin - Department of Psychology
UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
MESH Subject Adult ; Gyrus Cinguli ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Monte Carlo Method ; Nerve Net ; Neurons ; Phenotype ; Reference Values ; Algorithms ; Time Factors ; Young Adult ; Analysis of Variance ; Brain Mapping ; Cluster Analysis ; Cognition ; Female ; Frontal Lobe ; Fuzzy Logic
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Bibliographic reference Cauda, Franco ; Torta, Diana ; Sacco, Katiuscia ; D'Agata, Federico ; Geda, Elisabetta ; et. al. Functional anatomy of cortical areas characterized by Von Economo neurons.. In: Brain Structure and Function, Vol. 218, no.1, p. 1-20 (2012)
Permanent URL http://hdl.handle.net/2078/170185