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Experimental models of liver fibrosis.

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Crespo Yanguas, Sara Cogliati, Bruno Willebrords, Joost Maes, Michaël Colle, Isabelle Leclercq, Isabelle [UCL] Vinken, Mathieu

Hepatic fibrosis is a wound healing response to insults and as such affects the entire world population. In industrialized countries, the main causes of liver fibrosis include alcohol abuse, chronic hepatitis virus infection and non-alcoholic steatohepatitis. A central event in liver fibrosis is the activation of hepatic stellate cells, which is triggered by a plethora of signaling pathways. Liver fibrosis can progress into more severe stages, known as cirrhosis, when liver acini are substituted by nodules, and further to hepatocellular carcinoma. Considerable efforts are currently devoted to liver fibrosis research, not only with the goal of further elucidating the molecular mechanisms that drive this disease, but equally in view of establishing effective diagnostic and therapeutic strategies. The present paper provides a state-of-the-art overview of in vivo and in vitro models used in the field of experimental liver fibrosis research.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès interdit
Publication date 2016
Language Anglais
Journal information "Archives of Toxicology" - Vol. 90, no. 5, p. 1025–1048 (2016)
Peer reviewed yes
Publisher Springer ((Germany) Berlin)
issn 0340-5761
e-issn 1432-0738
Publication status Publié
Affiliations UCL - SSS/IREC/GAEN-Pôle d'Hépato-gastro-entérologie
UCL - SSS/IREC-Institut de recherche expérimentale et clinique
Keywords Animal models ; Hepatic stellate cells ; In vitro models ; Liver fibrosis
Links
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Bibliographic reference Crespo Yanguas, Sara ; Cogliati, Bruno ; Willebrords, Joost ; Maes, Michaël ; Colle, Isabelle ; et. al. Experimental models of liver fibrosis.. In: Archives of Toxicology, Vol. 90, no. 5, p. 1025–1048 (2016)
Permanent URL http://hdl.handle.net/2078.1/169106