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What is the Need for Prostatic Biomarkers in Prostate Cancer Management?

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Spahn, Martin Boxler, Silvan Joniau, Steven Moschini, Marco Tombal, Bertrand [UCL] Karnes, R Jeffrey

Discriminating patients with a low risk of progression from those with lethal prostate cancer is one of the main challenges in prostate cancer management. Indeed, such discrimination is essential if we aim to avoid overtreatment in men with indolent disease and to improve survival in those men with lethal disease. We are reporting on the current literature on such prognostic tools that are now available, their clinical role and their limitations in individualizing care. There is an urgent need to incorporate such genomic tools into new platform-based clinical trial structures to further develop and validate prognostic and predictive biomarkers and provide prostate cancer patients with an effective and cost-efficient access to new drugs in the setting of personalized treatment.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2015
Language Anglais
Journal information "Current Urology Reports" - Vol. 16, no.10, p. Article 70 (2015)
Peer reviewed yes
Publisher Springer Healthcare ((United States) Philadelphia)
issn 1527-2737
e-issn 1534-6285
Publication status Publié
Affiliations UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - (SLuc) Service d'urologie
Keywords Prostate cancer ; Genetics ; Microenvironment ; Treatment ; Biomarkers
Links
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Bibliographic reference Spahn, Martin ; Boxler, Silvan ; Joniau, Steven ; Moschini, Marco ; Tombal, Bertrand ; et. al. What is the Need for Prostatic Biomarkers in Prostate Cancer Management?. In: Current Urology Reports, Vol. 16, no.10, p. Article 70 (2015)
Permanent URL http://hdl.handle.net/2078.1/167491