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Weight loss at a high cost: Orlistat-induced late-onset severe kidney disease.

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Buysschaert, Benoit [UCL] Aydin, Selda [UCL] Morelle, Johann [UCL] Hermans, Michel [UCL] Jadoul, Michel [UCL] Demoulin, Nathalie [UCL]

(eng) AIM: This report describes a case of kidney failure secondary to orlistat, a lipase inhibitor commonly used in the treatment of obesity. CASE REPORT: An 80-year-old man with type 2 diabetes who was being treated with orlistat developed rapidly progressive kidney failure. Low-grade albuminuria argued against diabetic nephropathy. Renal biopsy showed tubulointerstitial nephritis associated with numerous calcium oxalate crystals. Enteric hyperoxaluria was attributed to the orlistat treatment. The latter was stopped and the patient received calcium supplements. Six months after orlistat withdrawal, oxaluria was normalized and kidney function stabilized. CONCLUSION: Oxalate nephropathy may result from hyperoxaluria secondary to orlistat treatment. This suggests that kidney function and oxaluria be closely monitored in patients taking orlistat.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2016
Language Anglais
Journal information "Diabetes & Metabolism" - Vol. 42, no. 1, p. 62-64 (2016)
Peer reviewed yes
Publisher Elsevier Masson ((France) Paris)
issn 1262-3636
e-issn 1878-1780
Publication status Publié
Affiliations UCL - SSS/IREC/NEFR - Pôle de Néphrologie
UCL - (SLuc) Service de néphrologie
UCL - (SLuc) Service d'anatomie pathologique
UCL - (SLuc) Service d'endocrinologie et de nutrition
UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition
UCL - SSS/IREC/SLUC - Pôle St.-Luc
Keywords Hyperoxaluria ; Orlistat ; Oxalate nephropathy
Links
Bibliographic reference Buysschaert, Benoit ; Aydin, Selda ; Morelle, Johann ; Hermans, Michel ; Jadoul, Michel ; et. al. Weight loss at a high cost: Orlistat-induced late-onset severe kidney disease.. In: Diabetes & Metabolism, Vol. 42, no. 1, p. 62-64 (2016)
Permanent URL http://hdl.handle.net/2078.1/166636