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Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses

Bibliographic reference Smith, Shannon E. ; Hoelzinger, Dominique B. ; Dominguez, Ana Lucia ; Van Snick, Jacques ; Lustgarten, Joseph. Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses. In: Cancer Immunology, Immunotherapy : other biological response modifications, Vol. 60, no. 12, p. 1775-1787 (2011)
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  1. Gross Stefanie, Walden Peter, Immunosuppressive mechanisms in human tumors: Why we still cannot cure cancer, 10.1016/j.imlet.2007.11.012
  2. Sakaguchi Shimon, Yamaguchi Tomoyuki, Nomura Takashi, Ono Masahiro, Regulatory T Cells and Immune Tolerance, 10.1016/j.cell.2008.05.009
  3. Leffers Ninke, Gooden Marloes J. M., de Jong Renske A., Hoogeboom Baukje-Nynke, ten Hoor Klaske A., Hollema Harry, Boezen H. Marieke, van der Zee Ate G. J., Daemen Toos, Nijman Hans W., Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer, 10.1007/s00262-008-0583-5
  4. Horwitz David A., Zheng Song Guo, Gray J. Dixon, Natural and TGF-β–induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other, 10.1016/
  5. Chen WanJun, Jin Wenwen, Hardegen Neil, Lei Ke-jian, Li Li, Marinos Nancy, McGrady George, Wahl Sharon M., Conversion of Peripheral CD4+CD25−Naive T Cells to CD4+CD25+Regulatory T Cells by TGF-β Induction of Transcription FactorFoxp3, 10.1084/jem.20030152
  6. Zhou G., Levitsky H. I., Natural Regulatory T Cells and De Novo-Induced Regulatory T Cells Contribute Independently to Tumor-Specific Tolerance, 10.4049/jimmunol.178.4.2155
  7. Wada J, Suzuki H, Fuchino R, Yamasaki A, Nagai S, Yanai K, Koga K, Nakamura M, Tanaka M, Morisaki T, Katano M (2009) The contribution of vascular endothelial growth factor to the induction of regulatory T-cells in malignant effusions. Anticancer Res 29:881–888
  8. Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E (1999) Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 59:3128–3133
  9. Kretschmer Karsten, Apostolou Irina, Verginis Panos, von Boehmer Harald, Regulatory T Cells and Antigen-Specific Tolerance, Chemical Immunology and Allergy (2008) ISBN:9783805586283 p.8-15, 10.1159/000154846
  10. Dominguez A. L., Lustgarten J., Implications of Aging and Self-Tolerance on the Generation of Immune and Antitumor Immune Responses, 10.1158/0008-5472.can-07-6436
  11. Hoelzinger D. B., Smith S. E., Mirza N., Dominguez A. L., Manrique S. Z., Lustgarten J., Blockade of CCL1 Inhibits T Regulatory Cell Suppressive Function Enhancing Tumor Immunity without Affecting T Effector Responses, 10.4049/jimmunol.0904084
  12. Couper K. N., Lanthier P. A., Perona-Wright G., Kummer L. W., Chen W., Smiley S. T., Mohrs M., Johnson L. L., Anti-CD25 Antibody-Mediated Depletion of Effector T Cell Populations Enhances Susceptibility of Mice to Acute but Not Chronic Toxoplasma gondii Infection, 10.4049/jimmunol.0803053
  13. Barton Gregory M, Medzhitov Ruslan, Control of adaptive immune responses by Toll-like receptors, 10.1016/s0952-7915(02)00343-6
  14. Kaisho Tsuneyasu, Akira Shizuo, Toll-like receptors as adjuvant receptors, 10.1016/s0167-4889(01)00182-3
  15. Huang Q., The Plasticity of Dendritic Cell Responses to Pathogens and Their Components, 10.1126/science.294.5543.870
  16. Takeda Kiyoshi, Akira Shizuo, Toll receptors and pathogen resistance, 10.1046/j.1462-5822.2003.00264.x
  17. Sharma S., Dominguez A. L., Manrique S. Z., Cavallo F., Sakaguchi S., Lustgarten J., Systemic Targeting of CpG-ODN to the Tumor Microenvironment with Anti-neu-CpG Hybrid Molecule and T Regulatory Cell Depletion Induces Memory Responses in BALB-neuT Tolerant Mice, 10.1158/0008-5472.can-08-1635
  18. Watts Tania H., TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES, 10.1146/annurev.immunol.23.021704.115839
  19. Cuadros C, Dominguez AL, Frost GI, Borgstrom P, Lustgarten J (2003) Cooperative effect between immunotherapy and antiangiogenic therapy leads to effective tumor rejection in tolerant Her-2/neu mice. Cancer Res 63:5895–5901
  20. Cuadros Camilo, Dominguez Ana Lucia, Lollini Pier-Luigi, Croft Michael, Mittler Robert S., Borgström Per, Lustgarten Joseph, Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice, 10.1002/ijc.21098
  21. Lustgarten Joseph, Dominguez Ana Lucia, Cuadros Camilo, The CD8+ T cell repertoire against Her-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity, 10.1002/eji.200324427
  22. Rovero S., Amici A., Carlo E. D., Bei R., Nanni P., Quaglino E., Porcedda P., Boggio K., Smorlesi A., Lollini P.-L., Landuzzi L., Colombo M. P., Giovarelli M., Musiani P., Forni G., DNA Vaccination Against Rat Her-2/Neu p185 More Effectively Inhibits Carcinogenesis Than Transplantable Carcinomas in Transgenic BALB/c Mice, 10.4049/jimmunol.165.9.5133
  23. Xia J., Tanaka Y., Koido S., Liu C., Mukherjee P., Gendler S. J., Gong J., Prevention of Spontaneous Breast Carcinoma by Prophylactic Vaccination with Dendritic/Tumor Fusion Cells, 10.4049/jimmunol.170.4.1980
  24. Fontenot Jason D., Rasmussen Jeffrey P., Williams Luke M., Dooley James L., Farr Andrew G., Rudensky Alexander Y., Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3, 10.1016/j.immuni.2005.01.016
  25. Choi B. K., 4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells, 10.1189/jlb.1003491
  26. Valzasina B., Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR, 10.1182/blood-2004-07-2959
  27. Noelle Randolph J., Nowak Elizabeth C., Cellular sources and immune functions of interleukin-9, 10.1038/nri2848
  28. Fontenot Jason D, Rasmussen Jeffrey P, Gavin Marc A, Rudensky Alexander Y, A function for interleukin 2 in Foxp3-expressing regulatory T cells, 10.1038/ni1263
  29. Cooper David, Bansal-Pakala Pratima, Croft Michael, 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cellsin vivo but does not contribute to the development of cytotoxicity, 10.1002/1521-4141(200202)32:2<521::aid-immu521>;2-x
  30. Piconese Silvia, Valzasina Barbara, Colombo Mario P., OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection, 10.1084/jem.20071341
  31. Piconese Silvia, Pittoni Paola, Burocchi Alessia, Gorzanelli Andrea, Carè Alessandra, Tripodo Claudio, Colombo Mario P., A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2, 10.1002/eji.201040505
  32. Ruby C. E., Yates M. A., Hirschhorn-Cymerman D., Chlebeck P., Wolchok J. D., Houghton A. N., Offner H., Weinberg A. D., Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right, 10.4049/jimmunol.0901112
  33. Lu Li-Fan, Lind Evan F., Gondek David C., Bennett Kathy A., Gleeson Michael W., Pino-Lagos Karina, Scott Zachary A., Coyle Anthony J., Reed Jennifer L., Van Snick Jacques, Strom Terry B., Zheng Xin Xiao, Noelle Randolph J., Mast cells are essential intermediaries in regulatory T-cell tolerance, 10.1038/nature05010
  34. Veldhoen Marc, Uyttenhove Catherine, van Snick Jacques, Helmby Helena, Westendorf Astrid, Buer Jan, Martin Bruno, Wilhelm Christoph, Stockinger Brigitta, Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset, 10.1038/ni.1659
  35. Elyaman W., Bradshaw E. M., Uyttenhove C., Dardalhon V., Awasthi A., Imitola J., Bettelli E., Oukka M., van Snick J., Renauld J.-C., Kuchroo V. K., Khoury S. J., IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells, 10.1073/pnas.0812530106
  36. Fukushima A., Yamaguchi T., Ishida W., Fukata K., Mittler R. S., Yagita H., Ueno H., Engagement of 4-1BB Inhibits the Development of Experimental Allergic Conjunctivitis in Mice, 10.4049/jimmunol.175.8.4897
  37. Sun Y., Blink S. E., Liu W., Lee Y., Chen B., Solway J., Weinstock J., Chen L., Fu Y.-X., Inhibition of Th2-Mediated Allergic Airway Inflammatory Disease by CD137 Costimulation, 10.4049/jimmunol.177.2.814
  38. Rochman Yrina, Spolski Rosanne, Leonard Warren J., New insights into the regulation of T cells by γc family cytokines, 10.1038/nri2580
  39. Yao Z., Kanno Y., Kerenyi M., Stephens G., Durant L., Watford W. T., Laurence A., Robinson G. W., Shevach E. M., Moriggl R., Hennighausen L., Wu C., O'Shea J. J., Nonredundant roles for Stat5a/b in directly regulating Foxp3, 10.1182/blood-2006-11-055756
  40. Burchill M. A., Yang J., Vogtenhuber C., Blazar B. R., Farrar M. A., IL-2 Receptor  -Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells, 10.4049/jimmunol.178.1.280
  41. Townsend Michael J, Fallon Padraic G, Matthews David J, Smith Philip, Jolin Helen E, McKenzie Andrew N.J, IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development, 10.1016/s1074-7613(00)00056-x
  42. Sharma Sanjay, Dominguez Ana Lucia, Hoelzinger Dominique B., Lustgarten Joseph, CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: the implications for vaccinations in the aged, 10.1007/s00262-007-0393-1
  43. Eller K., Wolf D., Huber J. M., Metz M., Mayer G., McKenzie A. N. J., Maurer M., Rosenkranz A. R., Wolf A. M., IL-9 Production by Regulatory T Cells Recruits Mast Cells That Are Essential for Regulatory T Cell-Induced Immune Suppression, 10.4049/jimmunol.1001183
  44. Nowak Elizabeth C., Weaver Casey T., Turner Henrietta, Begum-Haque Sakhina, Becher Burkhard, Schreiner Bettina, Coyle Anthony J., Kasper Lloyd H., Noelle Randolph J., IL-9 as a mediator of Th17-driven inflammatory disease, 10.1084/jem.20090246
  45. White Barbara, Leon Francisco, White Wendy, Robbie Gabriel, Two first-in-human, open-label, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers, 10.1016/j.clinthera.2009.04.019